The dose of procaine (in mg/kg/min) necessary to obtain a satisfactory light level of general anaesthesia in children from 18 to 168 months old, diminishes with increasing age. There is no difference in the procaine requirement between sexes. When higher doses of procaine are injected, greater amounts of gallamine are needed to maintain satisfactory relaxation. Young children require higher doses of gallamine than the older ones. A curvilinear regression has been constructed so that mg/kg/min doses of procaine in relation to sex and age can easily be found.
A method for the bio-assay of curarizing agents is described. Suxamethonium is injected intravenously into anaesthetized and intubated rats. The response is measured as the time of respiratory depression. Doses ranging from 0.311 to 1.05 p.g/g give rise to linear responses when the time of respiratory depression is plotted against log dose. The assays are performed within this range. High and low doses, both of the standard and unknown, are injected into two animals each. The index of precision is 0.14. Precision, specificity, cheapness and the possibility of a wider use (cholinesterase determination) are emphasized.
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