Potentiation of Succinylcholine by Procaine

Salgado, Alejandro Stilmann

doi:10.1097/00000542-196111000-00005

Cited by 5 publications

(1 citation statement)

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“…Metabolism. Procaine and trimetaphan are broken down by plasma-cholinesterase and if used with suxamethonium may produce a prolonged effect (Foldes et al, 1953;Salgado, 1961). Anticholinesterases such as tetrahydroaminoacridine and hexafluorenium have been used for this very purpose (Foldes et al, 1960).…”

Section: Drugs Affecting the Metabolism And Excretion Of Muscle Relaxmentioning

confidence: 99%

The Influence of Drugs Used in Therapeutics on the Action of Muscle Relaxants

Emery

1963

British Journal of Anaesthesia

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When one considers the many types of chemical compound used in modern therapeutics, it is not surprising that some of these modify the action of muscle relaxants. In general such substances may interfere with neuromuscular transmission, or may influence relaxants by actions at other sites. Some such side effects are well known. Others, based on animal experiments on many different species and under varying conditions, are more difficult to assess precisely. Nevertheless, it would be unwise for the anaesthetist to ignore the possible risks they suggest. Although it is difficult to classify drugs accurately according to their pharmacological action at the neuromuscular junction, they may be grouped under the following headings. It must, however, be remembered that one drug may have several effects. (1) Drugs influencing the release or metabolism of acetylcholine. (2) Drugs altering the sensitivity of the motor endplate. (3) Drugs affecting the metabolism and excretion of muscle relaxants. DRUGS INFLUENCING THE RELEASE OR METABOLISM OF ACETYLCHOLINE Magnesium. Magnesium ions block the release of acetylcholine at the neuromuscular junction. They may also stabilize the endplate, making it resistant to the effects of acetylcholine. These actions, together with the accelerating action of magnesium ions on the action of the true cholinesterases (del Castillo and Engbaek, 1954), potentiate the actions of the antidepolarizing relaxants which in turn will also potentiate the action of magnesium. However, high enough concentrations of this ion are unlikely to be encountered except perhaps in the magnesium treatment of eclampsia. The neuromuscular block produced by magnesium is reversed by calcium ions.

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Section: Drugs Affecting the Metabolism And Excretion Of Muscle Relaxmentioning

confidence: 99%