Physiologically stable F127-GO supramolecular hydrogel with sustained drug release characteristic for chemotherapy and photothermal therapy

Abstract

The F127-GO-DOX supramolecular hydrogel system with sustained drug release characteristic for chemotherapy and photothermal therapy.

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

“…To minimize the negative influence on normal tissues, antibacterial substances are usually incorporated into hydrogels to work with photothermal effects. Hydrogels can load drugs via hydrogen bonds [ 39 ], π−π stacking [ 40 ], dynamic chemical bonds [ 41 ], and electrostatic absorption [ 42 , 43 ]. Furthermore, hyperthermia can effectively alleviate intermolecular forces or shrink volume to achieve rapid drug release to enhance the therapeutic effect [ 44 , 45 , 46 , 47 ].…”

Graphene Integrated Hydrogels Based Biomaterials in Photothermal Biomedicine

“…The A549 cell inhibition rate of F127-GO-DOX after 808 nm laser exposure was increased to 60%, which was higher than the 40% inhibition rate of non-drug-loaded carriers due to the synergistic effects of chemo-PTT. In an in vivo study, F127-GO-DOX effectively suppressed tumor growth under NIR treatment after 14 days, indicating that the strong photothermal effect of GO significantly increased the chemo-PTT therapeutic effect of this hydrogel under NIR laser [ 136 ].…”

“…The A549 cell inhibition rate of F127-GO-DOX after 808 nm laser exposure was increased to 60%, which was higher than the 40% inhibition rate of non-drug-loaded carriers due to the synergistic effects of chemo-PTT. In an in vivo study, F127-GO-DOX effectively suppressed tumor growth under NIR treatment after 14 days, indicating that the strong photothermal effect of GO significantly increased the chemo-PTT therapeutic effect of this hydrogel under NIR laser [136]. Gold nanomaterials have been utilized to improve the thermal-responsive therapeutic efficiency of GGels as PTT mediators owing to their properties, including strong photothermal conversion, high biocompatibility and straightforward surface modification [138][139][140].…”

Reinforced macromolecular micelle-crosslinked hyaluronate gels induced by water/DMSO binary solvent

“…Generally, F127 usually has two prominent diffraction peaks located at 2θ = 19.3° and 23.4°, which are assigned to the (100) and (200) crystal planes. [31][32][33] Alternatively, HA exhibits a broad characteristic peak at 2θ = ∼20° due to the crystallites. 34 However, the intensity of diffraction peaks for the FH 0 hydrogel is hardly visible, indicating a full hydration status of MeHA chains and no dense stack of F127DA micelles (Fig.…”

“…It showed serious structural damage upon cyclic loadings and a slow recovery in the presence of DMSO within the networks. 31 Therefore, the hydrogenbonds from MeHA endow the FH 1.0 organogel with anti-damage and rapid self-recovery after loading-unloading tests.…”