Physiological features of aggregation of the main formed elements of blood in calves at the beginning of early ontogenesis

Glagoleva, T; Медведев, И. Н.

doi:10.1051/bioconf/20201700161

Cited by 32 publications

(22 citation statements)

References 6 publications

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“…Under conditions of a gradual increase in the synthesis of prostacyclin and nitric oxide in vessels, the increasing effect of weak aggregation inducers -ADP and adrenaline on platelet receptors was physiologically balanced [20,21]. Apparently, the achieved effect is based on a decrease in the density and activity of platelet glycoproteins, which function as their receptors, as well as fibrinogen receptors (GPIIb-IIIa) [22,23]. These receptor changes were inevitably accompanied by a weakening of the activity of phospholipase A2 in platelets of piglets, which led to the elimination of a limited amount of arachidonic acid from their phospholipids [24,25].…”

Section: Discussionmentioning

confidence: 99%

Disaggregated control of blood vessels over platelets in milk piglets

Tkacheva

2020

BIO Web Conf.

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The important element in the functioning of hemostasis in the body of a piglet is platelet aggregation activity. The degree of its severity in piglets largely controls the functional state of primary hemostasis and the severity of microcirculation in their tissues, determining the formation of many functional mechanisms. The aggregation activity of platelets in early ontogenesis significantly determines the growth and development of the animal in the future and ultimately the level of its productivity. The examination of 36 healthy piglets of milk nutrition showed a decrease in the content of peroxidation products in their blood as a result of increased activity of their antioxidant potential in plasma. This led to their weak platelet alteration, contributing to their optimal aggregation activity. In piglets during the phase of milk feeding, a gradual increase in the aggregation properties of platelets is noted, regulating blood flow in vessels of the smallest caliber.

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Section: Discussionmentioning

confidence: 99%

Disaggregated control of blood vessels over platelets in milk piglets

Tkacheva

2020

BIO Web Conf.

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“…This process is associated with the influence of negative environmental factors. The development of hemostasiopathy threatens the appearance of vasospasm and disturbances in the process of blood rheology in small vessels, which is especially significant during the active growth of the animal [28]. This is always accompanied by platelet activation and increased hemocoagulation, which was also observed in a study on animals that suffered an episode of prolonged transport [29].…”

Section: 4±069mentioning

confidence: 96%

Restoring the functional state of the hemostasis system in piglets experiencing an episode of transportation

et al. 2020

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Negative environmental impact can often adversely affect the functional properties of piglets and significantly weaken their viability. It is often possible to judge this by the dynamics of the activity of hemostasis indicators. The level of activity of platelets and coagulation systems very early change activity in the case of negative influences from the outside, causing the appearance of overt hemostasiopathy. This condition leads to the disruption of hemocirculation in the capillaries and a decrease in the severity of metabolism in the tissues. These changes lead to a slowdown in growth and a general weakening of animals, thereby leading to great economic damage. It was found that the appearance of transport stress in piglets leads to increased platelet aggregation and activation of homocoagulation mechanisms during inhibition of fibrinolysis. Due to the fact that this situation is very common, the possibility of eliminating these dysfunctions was studied. The study tested fumaric acid at 0.1 g/kg in the form of a feed additive for 20 days in piglets that underwent long-term transportation. As a result of using this supplement, it was possible to reduce platelet activity and blood coagulation and increase fibrinolysis activity, bringing them to control values. As a result of the study, it was found that the intake of fumaric acid in the body of piglets that have experienced the influence of a high-intensity medium optimizes the functional status of their hemostasis. This minimizes their risk of microthrombosis and weakened animal growth.

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“…The normal beginning of early ontogenesis and the activity of adaptive mechanisms to environmental factors in calves and piglets is very dependent on hemocirculation in small vessels [9]. Moreover, the course of microcirculation is largely determined by the state of hemostatic mechanisms [10].…”

Section: Introductionmentioning

confidence: 99%

Functional features of hemostasis in physically weakened newborn piglets and calves

Крапивина

Novikova

2020

BIO Web Conf.

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The normal state of hematological parameters in mammals at the beginning of ontogenesis is rightfully considered to be functionally very significant for the development of early ontogenesis in them. Hemostasis is considered to be very significant for vital functions and vulnerable blood systems. Its condition affects trophism due to the effect on the state of microcirculation, which is very important at the beginning of ontogenesis. In the neonatal phase, calves and piglets develop the formation of hemostasis and therefore, during these periods it can be easily disrupted. The appearance of hemostatic dysfunctions in the body of young animals, despite its importance, is still very poorly studied. This circumstance was the motivation for the study of the activity of the hemostatic system in calves and piglets that were born physically weakened. It was found that immediately after birth in weakened calves and piglets, there are physiologically unfavorable changes in platelet activity, vascular hemostasis and blood coagulation. This provides them with the appearance of excessive platelet activity and blood clotting with a significant weakening of vascular hemostasis. All these disorders lead to negative changes in their internal organs and create their serious dysfunctions. The development of disorders in the mechanisms of hemostasis in physically weakened calves and piglets during the neonatal phase is a serious mechanism for weakening their adaptation to the environment and slowing the growth and development of animals.

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Physiological features of aggregation of the main formed elements of blood in calves at the beginning of early ontogenesis

Cited by 32 publications

References 6 publications

Disaggregated control of blood vessels over platelets in milk piglets

Disaggregated control of blood vessels over platelets in milk piglets

Restoring the functional state of the hemostasis system in piglets experiencing an episode of transportation

Functional features of hemostasis in physically weakened newborn piglets and calves

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