Physiological Effects Of Melatonin on Leptin, Testosterone and Biochemical Parameters in Albino Rats

Mahmud, Sarbast A.

doi:10.9790/3013-034204853

Cited by 3 publications

(1 citation statement)

References 35 publications

(23 reference statements)

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“…The data of the present study indicated that in shamoperated surgery and PINx rats leads to regressive histological changes in testicular tissue. This result is supported by Mahmud and Mahmud, finding that male albino rats were given MEL 60 mg / kg diet and MEL 120 mg / kg, the level of testosterone was significantly decreased in ratio 30% and 60% respectively [16]. Furthermore, Masson-Pevet et al, (1987) [17], found that MEL play protective role in gonads, and they showed that exposure of hamster to short photoperiod leads to regression of testicular tissue.…”

Section: Tikrit Journal Of Pure Science 22 (9) 2017 Issn: 1813 -1662 ...mentioning

confidence: 65%

Histological effects of melatonin on testes in pinealectomized and normal albino rats

Abdulla¹,

Mahmud²,

Khdhr³

2023

Tikrit J. Pure Sci.

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In the present study, the histological effect of melatonin (MEL) on pinealectomized (PINx) and normal rats’ testes was investigated. Thirty six adult male rats were used in this study. The rats were divided into six experimental groups as follow: 1st control group; 2nd sham-operated surgery rats group; 3rd PINx rats group, 4th PINx rats+MEL (60 mg / Kg diet) group; 5th control rats+MEL (60 mg / Kg diet) group; and 6th control rats+MEL (120 mg / Kg diet) group and the treatments were continued for six weeks. The result showed mild histological changes in testicular tissue of sham-operated surgery rats, like shrinkage and atrophy of seminiferous tubules (STs) and weakness in spermatogenesis. While, in PINx rats revealed regressive changes in testicular tissue, like sever degeneration, vacuolation and necrosis in germinal epithelium and no spermatogenesis. But as PINx rats were given MEL 60 mg/kg diet, the testicular structure and function were recovered, whereas, in normal rats were given MEL 60 and 120 mg/kg diet, the result show sever vacuolation and sloughing of spermatocytes inside STs lumen and no spermatogenesis at rats+60 MEL and mild edema with well development of germinal epithelium and spermatogenesis at rats+120 MEL. In conclusion, the deficiency of MEL level leads to change in histology and physiological activities of rat testes

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Section: Tikrit Journal Of Pure Science 22 (9) 2017 Issn: 1813 -1662 ...mentioning

confidence: 65%

Histological effects of melatonin on testes in pinealectomized and normal albino rats

Abdulla¹,

Mahmud²,

Khdhr³

2023

Tikrit J. Pure Sci.

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Green Synthesis of Bioactive CuO@Fe3O4@Walnut Shell Nanocomposite Using Crataegus azarolus Var. aronia L. Extract and its Antivasoconstrictive Action on Rat’s Aortic Smooth Muscle

Mahmud

2021

Polytechnic j.

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The antioxidant potential of Crataegus azarolus Var. aronia aqueous extract was used as reducing and stabilizing media to the green synthesis of bioactive CuO@Fe3O4@Walnut shell nanocomposite (NCs). The ability of the plant extract as bioreducing medium was proved using Fourier-transform infrared spectroscopy and ultraviolet–visible spectroscopy. While, the structural identification of synthesized CuO@Fe3O4@Walnut shell NCs was proved using the scanning electron microscopy, electron dispersive spectroscopy, elemental mapping, and point analysis. Then, the antivasoconstriction effects of CuO@Fe3O4@Walnut shell NCs (5*10−2 mg/ml) and (1*10−1 mg/ml) on rats isolated thoracic aortic smooth muscle cells were studied. Green synthesized CuO@Fe3O4@Walnut shell NCs showed effective antivasoconstriction activity against norepinephrine (NE) (1*10−9–10−4 M) induced contraction in endothelium-intact and endothelium-denuded rats aortic smooth muscle. In conclusion, the aqueous extract of C. aronia acts as potential reducing and stabilizing media to the green synthesis of bioactive CuO@Fe3O4@Walnut shell NCs and the NCs play an important role against contractile effects of NE on rats’ aortic smooth muscle.

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Effect of Exogenous Melatonin Treatment on the Reproductive Characteristics and Progeny of Male Rats Exposed to Different Periods From Light and Darkness

Majrashi

Barakat

Alhimaidi³

et al. 2017

Physiol Res

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Light is an important environmental factor that controls the regulation of physiological functions of organisms. Melatonin is considered as one of the major hormones that play an important role in protecting body from many harmful effects and acts as a powerful anti-oxidant source to controlling the levels of antioxidant enzymes within the body. The main objectives of this work were to study the effect of 1) photoperiod changes and 2) exogenous melatonin hormone treatment on the sperm properties, body and testis weight, embryo characteristics, and concentration level of melatonin and testosterone in treated rat serum. This study has been conducted using thirty-six male rats and one hundred and twenty female rats. Animals were divided into six groups, each group containing six males and twenty female rats. Our results showed a significant influence of photoperiod changes on the melatonin and testosterone hormones concentration in rats’ serum, body weight only, while the other characteristics not affected. As for the effect of melatonin it has been found that the movement of sperm in GIII and IV, as well as embryos absorbed and newborns weight traits has been significantly affected, while the rest of the properties were not significantly affected by melatonin treatment.

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Physiological Effects Of Melatonin on Leptin, Testosterone and Biochemical Parameters in Albino Rats

Abstract: : The

Cited by 3 publications

References 35 publications

Histological effects of melatonin on testes in pinealectomized and normal albino rats

Histological effects of melatonin on testes in pinealectomized and normal albino rats

Green Synthesis of Bioactive CuO@Fe3O4@Walnut Shell Nanocomposite Using Crataegus azarolus Var. aronia L. Extract and its Antivasoconstrictive Action on Rat’s Aortic Smooth Muscle

Effect of Exogenous Melatonin Treatment on the Reproductive Characteristics and Progeny of Male Rats Exposed to Different Periods From Light and Darkness

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