In the present study, the histological effect of melatonin (MEL) on pinealectomized (PINx) and normal rats’ testes was investigated. Thirty six adult male rats were used in this study. The rats were divided into six experimental groups as follow: 1st control group; 2nd sham-operated surgery rats group; 3rd PINx rats group, 4th PINx rats+MEL (60 mg / Kg diet) group; 5th control rats+MEL (60 mg / Kg diet) group; and 6th control rats+MEL (120 mg / Kg diet) group and the treatments were continued for six weeks. The result showed mild histological changes in testicular tissue of sham-operated surgery rats, like shrinkage and atrophy of seminiferous tubules (STs) and weakness in spermatogenesis. While, in PINx rats revealed regressive changes in testicular tissue, like sever degeneration, vacuolation and necrosis in germinal epithelium and no spermatogenesis. But as PINx rats were given MEL 60 mg/kg diet, the testicular structure and function were recovered, whereas, in normal rats were given MEL 60 and 120 mg/kg diet, the result show sever vacuolation and sloughing of spermatocytes inside STs lumen and no spermatogenesis at rats+60 MEL and mild edema with well development of germinal epithelium and spermatogenesis at rats+120 MEL. In conclusion, the deficiency of MEL level leads to change in histology and physiological activities of rat testes
Summary:The objective for the present study is to investigate the effects of melatonin (MEL) on systolic blood pressure (SBP), some biochemical parameters; serum (malondialdehyde (MDA), superoxide dismutase (SOD), reduced glutathione (GSH), nitric oxide (NO)) in NG-nitro-L-arginine methyl ester hydrochloride (L-NAME) treated rats. The male albino rats divided into five groups treated for 4 weeks: Group 1: Control rats. Group 2: L-NAME (35 mg/100 ml drinking water). Group 3: L-NAME (35 mg/100 ml drinking water) + melatonin (30 mg/Kg diet). Group 4: L-NAME (35 mg/100 ml drinking water) + melatonin (60 mg/Kg diet). Group 5: L-NAME (35 mg/100 ml drinking water) + melatonin (120 mg/Kg diet). A significant elevation in SBP and serum MDA were detected in L-NAME treated rats. Coadministration of melatonin with L-NAME prevented increasing in SBP and serum level of MDA in a dose dependent manner. On the other hand serum levels of SOD and GSH were decreased in response to L-NAME treatment, while, co-treatment with melatonin increased SOD and GSH in a dose dependent manner. The decrease serum NO level in response to L-NAME was significantly increased by melatonin but its level was decreased by increasing melatonin doses.In conclusion: L-NAME induced hypertension model was associated with decreased NO level, interestingly; melatonin increased serum NO in L-NAME treatments, but with increasing dose of MEL, NO level was decreased. Furthermore; MEL through its antioxidant properties reduced oxidative stress and prevented lipid peroxidation.
This study attempts to find out the curative effects of Allium siculum (A. siculum) on ethylene glycol (EG) induced kidney stone in male albino rats. Throughout this study, twenty-two male albino rats were taken and divided into four experimental groups. Group A is a control group, while the rest of the groups, namely group B, C, and D animals, received 1% EG in water for 14 days, then from day 15 to day 28, the treatment of EG stopped and group C and D animals from day 15 to day 28 received A. siculum (5g of dried powder in 100 ml water and 950 g standard diet) and cystone (2.5 tablets in water and standard diet) respectively. Serum uric acid, creatinine, urea, lipid profile measurements, and glucose were evaluated besides the kidneys' weight and body weight gain. Allium siculum and cystone treatments indicated a significant reduction in serum uric acid, creatinine, urea, glucose, very low-density lipoprotein, and triglyceride compared to EG-treated rats. The kidneys' weight and body weight gains significantly increased in group B compared with A, C, and D. In conclusion: A. siculum has curative effects on ethylene glycol induced kidney stone which resembled the cystone drug.
The study was designed to investigates the therapeutic roles of Crataegus azarolus Var. aronia L. (C. aronia) in kidney stone treatment male albino rats’ model induced by ethylene glycol (EG). Twenty animals weighing 220–270 g were divided into control group which set as group A, while the rats in B and C groups, received 1% EG for 28 days, but group C also received C. aronia (7.5g of plant/100ml water and 10g of plant/ 90 g diet) from day 15 to 28. Kidney function tests, liver function tests, serum electrolytes, serum lipid profiles, and glucose were measured. The obtain body weight, kidneys' weight and kidneys' weight/ body weight were measured, in addition microscopic analysis of formed crystals from urine was studied. Crataegus aronia administration showed a marked declination in serum creatinine, urea, cholesterol, triglyceride (TG), very low-density lipoprotein (VLDL), and non-high density lipoprotein cholesterol (non-HDL cholesterol) inverse to rats received EG. Also, the obtain body weight, kidneys' weight and kidneys' weight/ body weight markedly decreased in C group when compared to group B. In conclusion: C. aronia has clear therapeutic actions on formed kidney stone might be used employee as natural antiurolithiasis drug.
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