Physicochemical properties and thermal stability of quercetin hydrates in the solid state

Borghetti, Greice Stefani; Carini, Juliana Poglia; Honorato, Sara B.; Ayala, A. P.; Moreira, José Cláudio Fonseca; Bassani, Valquíria Linck

doi:10.1016/j.tca.2012.04.015

Cited by 67 publications

(69 citation statements)

References 25 publications

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“…Since an alkaline extraction method was used to produce the A. mollis extract in this study, it is possible that the active ingredients(s) in the extract could be fl avonoid glycosides. Moreover, most fl avonoids exist as glycosides or polymers and are thermo stable (21); this is in agreement with our findings that the active ingredient(s) in A. mollis extract have molecular weights between 10 and 30 kDa and exhibit thermal stability.…”

Section: Discussionsupporting

confidence: 92%

Anti-influenza activity of Alchemilla mollis extract: Possible virucidal activity against influenza virus particles

Makau¹

2013

Drug Discov Ther

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Influenza virus infection is a major public health problem that leads to significant morbidity and mortality. The emergence of resistance to the currently available anti-influenza agents has necessitated the development of new drugs with novel targets. Studying known ethno-medicinal plants is a promising approach for the discovery of new antiviral compounds. Alchemilla mollis is used in traditional medicine in Europe for different indications, including minimizing the symptoms of a sore throat. In this study, we found that A. mollis extract has anti-influenza activity, and investigated the mechanism underlying its inhibition of influenza virus replication. Plaque assays demonstrated that treatment of cells with A. mollis extract prior to infection did not inhibit influenza virus infection. However, plaque formation was markedly reduced when infected cells were overlaid with an agarose gel containing A. mollis extract. In addition, exposure of the virus to A. mollis extract prior to infection and treatment of cells during virus infection significantly suppressed plaque formation. Influenza virusinduced hemagglutination of chicken red blood cells was inhibited by A. mollis extract treatment. The inhibitory effect was observed against influenza A virus subtypes H1N1, H3N2, and H5N2. These findings suggest that A. mollis extract has virucidal or neutralizing activity against influenza virus particles. Furthermore, inhibitory effect of zanamivir synergistically increased after combination with A. mollis extract. Our results suggest that A. mollis extract has the potential to be developed as an antiinfluenza agent.

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Section: Discussionsupporting

confidence: 92%

Anti-influenza activity of Alchemilla mollis extract: Possible virucidal activity against influenza virus particles

Makau¹

2013

Drug Discov Ther

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“…This phenomenon can be associated with the hydration state of quercetin. Borghetti et al [42] studied the different crystalline forms of quercetin by high temperature X-ray powder diffraction method. Our samples show identical patterns with their sample called QCTc heat treated at 40 °C, but the exact crystalline structure was not identified.…”

Section: Materials Characterizationmentioning

confidence: 99%

Experimental and theoretical study of quercetin complexes formed on pure silica and Zn-modified mesoporous MCM-41 and SBA-16 materials

Popova

Trendafilova

Szegedi

et al. 2016

Microporous and Mesoporous Materials

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SBA-16 and MCM-41 silica materials were synthesized and modified by post-synthesis method with different amounts of Zn (2 and 4 wt.%). Quercetin, a flavonol compound, was loaded by incipient wetness impregnation method on the pure silica and Zn-modified mesoporous MCM-41 and SBA-16 supports. The parent and drug loaded formulations were characterized by powder XRD, N 2 physisorption, thermal analysis, TEM, UV Vis and FT-IR spectroscopies. The formation of Zn:quercetin complex was studied by FT-IR spectroscopy and quantum-chemical calculations. Loading of quercetin on mesoporous carriers made the sustained delivery of the bioactive compound possible in a buffer with pH = 5.5, typical of dermal formulations. The results from the release experiments are in good accordance with the inter-action energy between the bioactive molecule and non-modified and Zn-modified mesoporous materials, predicted by the quantum-chemical calculations. For the first time the formation of the most stable Zn quercetin complexes loaded on the mesoporous silica materials were determined. The obtained mesoporous delivery systems with Zn-quercetin complex are promising as dermal formulations.

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“…As shown in the literature [29], there is some confusion about which crystal is being used in experiments, as the quality and form depend on the chemical supplier and experimentally varying conditions. Indeed, problems were verified while carrying out the experimental part of this work, since both AQ and MQ were employed to prepare Q/MCM-41 complexes and to measure IR spectra of molecules alone.…”

Section: Quercetinmentioning

confidence: 99%

Experimental and first-principles IR characterization of quercetin adsorbed on a silica surface

et al. 2016

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Physicochemical properties and thermal stability of quercetin hydrates in the solid state

Cited by 67 publications

References 25 publications

Anti-influenza activity of Alchemilla mollis extract: Possible virucidal activity against influenza virus particles

Anti-influenza activity of Alchemilla mollis extract: Possible virucidal activity against influenza virus particles

Experimental and theoretical study of quercetin complexes formed on pure silica and Zn-modified mesoporous MCM-41 and SBA-16 materials

Experimental and first-principles IR characterization of quercetin adsorbed on a silica surface

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