Experimental and theoretical study of quercetin complexes formed on pure silica and Zn-modified mesoporous MCM-41 and SBA-16 materials

Popova, Margarita; Trendafilova, Ivalina; Szegedi, Ágnes; Mihály, Judith; Németh, Péter; Marinova, Sylvia G.; Aleksandrov, Hristiyan A.; Vayssilov, Georgi N.

doi:10.1016/j.micromeso.2016.04.001

Cited by 23 publications

(13 citation statements)

References 50 publications

(53 reference statements)

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“…According to the literature, such a signal can be attributed to the charge transfer between silica lattice oxygen and transition metals, notably tetrahedral TaO 4 species dispersed on silica, 64,65 as well as tetrahedral Zn(II) incorporated within silicates. [66][67][68] This suggestions is supported by the similar presence of an intense band in the same UV region for monometallic Zn 3% -TUD-1 and Ta 2% -TUD-1 materials (Fig. S4 †).…”

Section: Resultssupporting

confidence: 58%

Properties and activity of Zn–Ta-TUD-1 in the Lebedev process

et al. 2020

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Section: Resultssupporting

confidence: 58%

Properties and activity of Zn–Ta-TUD-1 in the Lebedev process

et al. 2020

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“…The XRD patterns of the three forms were calculated by their single Quercetin can be found in modified SBA-15 samples in its anhydrous form, independently whether it contains Zn or not, as experienced also by our former study with SBA-16 and MCM-41 support [32]. This is due to the recrystallization process of the drug in ethanol by the loading procedure.…”

Section: Cytotoxicity Assaymentioning

confidence: 72%

Preparation of efficient quercetin delivery system on Zn-modified mesoporous SBA-15 silica carrier

Trendafilova

Szegedi

Mihály

et al. 2017

Materials Science and Engineering: C

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Mesoporous silica material type SBA-15 was modified with different amounts of Zn (2 and 4 wt. %) by incipient wetness impregnation method in ethanol. The parent, Zn-modified and quercetin loaded samples, were characterized by XRD, N2 physisorption, TEM, thermal gravimetric analysis, UV-Vis and FT-IR spectroscopies and in vitro release of quercetin at pH 5.5 which is typical of dermal formulations. By this loading method anhydrous quercetin was formed on the silica carrier. It was found that the different hydrate forms of quercetin (dihydrate, monohydrate, anhydrite) significantly influence the physico-chemical properties of the delivery system. It was found that hydrate forms of quercetin can be differentiated by XRD and by FT-IR spectroscopic methods. Thus, by evaluating the interaction of the drug with the silica carrier the changes due to its hydration state always have to be taken into account. Formation of Zn-quercetin complex was evidenced on zinc modified SBA-15 silica by FT-IR spectroscopy. High quercetin loading capacity (over 40 wt. %) could be achieved on the parent and Zn-containing SBA-15 samples. The in-vitro release process at pH=5.5 showed slower quercetin release from Zn-modified SBA-15 samples compared to the parent one.Additionally, the comparative cytotoxic experiments evidenced that quercetin encapsulated in Zn-modified silica carriers has superior antineoplastic potential against HUT-29 cells compared to free drug. Zn-modified SBA-15 silica particles could be promising carriers for dermal delivery of quercetin.

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“…Mesoporous silica materials [14][15][16][17][18][19][20] have not only proved their utilities as heterogeneous catalysts [21][22][23][24][25][26][27][28][29] for promoting various organic transformations, [30][31][32][33][34][35][36][37] but also nd interesting applications 38,39 in other research elds such as food chemistry, 40 production of bio-mass derived chemicals, [41][42][43][44][45] petrochemisry, 46-48 sensors, waste treatment, 49,50 optical materials and carriers. One of the most important advances in this eld is developing hybrid systems through functionalization of mesoporous silica materials.…”

Section: Introductionmentioning

confidence: 99%

Current advances in the utility of functionalized SBA mesoporous silica for developing encapsulated nanocatalysts: state of the art

Sadjadi

Heravi

2017

RSC Adv.

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The cavities of SBA mesoporous silica materials can be used as nanoreactors for embedding catalytic species such as nanoparticles, complexes and heteropolyacids etc. The encapsulated catalysts are renowned as superior catalytic systems regarding their catalytic activity, selectivity and reusability as well as suppressed leaching. An efficient method to improve the encapsulation of these catalysts, is in creating anchors for capturing catalytic species. It has been performed by functionalization of the surface of SBA mesoporous silica materials with various groups including sulfur, phosphorus and aminebased functional groups. The aim of this article is to review the recent advances (2014)(2015)(2016)(2017) in the field of the utility of functionalized SBA for developing encapsulated catalysts. In most cases the reusability of the catalyst and the leaching of the catalytic active species were discussed to disclose the role of functionalized SBA in heterogenizing and suppressing the leaching. Moreover, to show the superiority of these developed encapsulated catalysts, with a couple of examples we compared their catalytic activities with those of the conventional ones.

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Experimental and theoretical study of quercetin complexes formed on pure silica and Zn-modified mesoporous MCM-41 and SBA-16 materials

Cited by 23 publications

References 50 publications

Properties and activity of Zn–Ta-TUD-1 in the Lebedev process

Properties and activity of Zn–Ta-TUD-1 in the Lebedev process

Preparation of efficient quercetin delivery system on Zn-modified mesoporous SBA-15 silica carrier

Current advances in the utility of functionalized SBA mesoporous silica for developing encapsulated nanocatalysts: state of the art

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