Experimental and first-principles IR characterization of quercetin adsorbed on a silica surface

Halo, Migen; Ferrari, Anna Maria; Berlier, Gloria; Miletto, Ivana; Casassa, Silvia

doi:10.1007/s00214-016-1854-4

Cited by 5 publications

(5 citation statements)

References 32 publications

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“…The enlargement of the spectra in the region between 1000 and 2000 cm −1 reported in Figure allows to appreciate that the relevant bands of the flavonoid present in the spectrum of the functionalized apatitic sample fall in the same positions as in the spectrum of quercetin. In particular the positions of the ν C = O mode at about 1665 cm −1 , the aromatic C = C modes in the range 1400–1630 cm −1 and the ν C‐O/δ O‐H combination modes in the range 1300–1400 cm −1 , do not show any variation in the spectrum of HAQUE compared with that of QUE .…”

Section: Resultsmentioning

confidence: 87%

Quercetin and alendronate multi‐functionalized materials as tools to hinder oxidative stress damage

Forte

Torricelli

Boanini

et al. 2017

J Biomedical Materials Res

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In spite of its remarkable anti-oxidant, anti-inflammatory, anti-cancer properties and its possible inhibition activity towards bone resorption, quercetin therapeutic use is limited by its poor bioavailability. Herein we developed a new multifunctionalized system for the local administration of quercetin and alendronate, one of the most potent anti-osteoporotic drugs, with the aim to get a material with enhanced properties. To this purpose we loaded quercetin on hydroxyapatite functionalized with alendronate, as well as on hydroxyapatite. Characterization was performed by means of X-ray diffraction, FT-IR and Raman spectroscopies, thermogravimetric and spectrophotometric analyses. Loading of quercetin from hydro-alcoholic solution increased with time and reached a constant value of about 5 weight% on both substrates, without causing significant structural and morphological modifications. Quercetin functionalized materials exhibit relevant anti-oxidant properties, in agreement with their high radical scavenging activity, and a quercetin sustained release in phosphate buffer. In vitro osteoblast and osteoclast co-culture in a microenvironment altered by oxidative stress shows that both alendronate and quercetin significantly reduce osteoclast viability, whereas they are able to counteract the negative effect of oxidative stress on osteoblast viability and differentiation, suggesting that their relative amount in the functionalized materials can be utilized to tailor bone cells response. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 3293-3303, 2017.

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Section: Resultsmentioning

confidence: 87%

Quercetin and alendronate multi‐functionalized materials as tools to hinder oxidative stress damage

Forte

Torricelli

Boanini

et al. 2017

J Biomedical Materials Res

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“…Infrared spectroscopy is a powerful tool to investigate interface interactions in hybrid organicinorganic materials. It can be used to assess the molecular structure of surface grafted functionalizing groups, and the weak interactions taking place between silica surface and adsorbed/encapsulated drug molecules [28,[50][51][52][53][54][55][56][57][58]. The spectra of parent NH2-MSN and HA conjugated samples are reported in Figure 3, in the high and low frequency ranges (top and bottom panel, respectively).…”

Section: Qualitative Ha Analysis: Infrared Spectroscopymentioning

confidence: 99%

Hyaluronated mesoporous silica nanoparticles for active targeting: influence of conjugation method and hyaluronic acid molecular weight on the nanovector properties

Ricci

Zonari

Cannito

et al. 2018

Journal of Colloid and Interface Science

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We have prepared and evaluated the physico-chemical and biological properties of four different hyaluronated mesoporous silica nanoparticles (MSNs) samples (MSN/HA). Hyaluronic acid (HA) with two different molecular weights (200 and 6.4 kDa) was used for the conjugation of aminopropyl-functionalized MSN (NH-MSN), following two different procedures. Namely, samples HA200A and HA6.4A were prepared by reacting activated HA with NH-MSN (method A), while samples HA200B and HA6.4B were obtained carrying out HA activation in the presence of the nanoparticles (method B). The four samples showed similar hydrophilicity, but clear differences in the HA loading, textural properties, surface charge and stability of the suspensions. More in detail, conjugation using low molecular weight HA with method A resulted in low HA loading, with consequent scarce effects on dispersity and stability in physiological media. The highest yield and corresponding best performances were obtained with method B using high molecular weight HA. HA loading and molecular weight also influenced in a concerted way the biological response towards the MSNs of CD44 target cancer cells (CD44) and control cells (CD44): MDA-MB-231 and A2780, respectively. The absence of cytotoxicity was assessed. Moreover, the targeting ability of the best performing MSN/HA was confirmed by cellular uptake studies.

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“…The glass slides adsorbed and recovered 68.75 ± 0.01% of the total suspended amount of MWCNTs/TiO 2 adsorbate, producing a surface coverage 33.03 ± 0.07 × 10 −2 mg mm −2 ( Table 1 ). However, the improved efficiency in Q/MWCNTs/TiO 2 recovery by glass into 80.63 ± 0.38% to produce surface coverage of 35.63 ± 1.13 × 10 −2 mg mm −2 ( Table 1 ) was a result of the multiple opportunities of forming H-bonds required for adsorption [ 29 ]. Moreover, the water contact angle of untreated and Q-coated glass surfaces was changed from 60° and 64° (a hydrophilic feature) to 24° and 47° (an improved hydrophilic behavior) after coating by MWCNTs/TiO 2 and Q/MWCNTs/TiO 2 ( Figure 4 a–d), respectively.…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, immobilized biomolecules in tailor-made nanoscale architectures can significantly advance their behavior [ 28 ]. Quercetin (Q), a widely distributed flavonoid, forms H-bonds that increase its surface adsorption properties [ 29 ]. Likewise, Q was reported to be thermally stable [ 9 ], electro-chemically active [ 30 ] and biologically safe [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Novel Quercetin Titanium Dioxide-Decorated Multi-Walled Carbon Nanotubes Nanocomposite on Bacillus subtilis Biofilm Development

et al. 2018

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The present work was targeted to design a surface against cell seeding and adhering of bacteria, Bacillus subtilis. A multi-walled carbon nanotube/titanium dioxide nano-power was produced via simple mixing of carbon nanotube and titanium dioxide nanoparticles during the sol-gel process followed by heat treatment. Successfully, quercetin was immobilized on the nanocomposite via physical adsorption to form a quercetin/multi-walled carbon nanotube/titanium dioxide nanocomposite. The adhesion of bacteria on the coated-slides was verified after 24 h using confocal laser-scanning microscopy. Results indicated that the quercetin/multi-walled carbon nanotube/titanium dioxide nanocomposite had more negativity and higher recovery by glass surfaces than its counterpart. Moreover, coating surfaces with the quercetin-modified nanocomposite lowered both hydrophilicity and surface-attached bacteria compared to surfaces coated with the multi-walled carbon nanotubes/titanium dioxide nanocomposite.

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Experimental and first-principles IR characterization of quercetin adsorbed on a silica surface

Cited by 5 publications

References 32 publications

Quercetin and alendronate multi‐functionalized materials as tools to hinder oxidative stress damage

Quercetin and alendronate multi‐functionalized materials as tools to hinder oxidative stress damage

Hyaluronated mesoporous silica nanoparticles for active targeting: influence of conjugation method and hyaluronic acid molecular weight on the nanovector properties

Effect of Novel Quercetin Titanium Dioxide-Decorated Multi-Walled Carbon Nanotubes Nanocomposite on Bacillus subtilis Biofilm Development

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