Physicochemical, biopharmaceutical, and practical considerations for efficient nose-to-brain drug delivery

Laddha, Umesh D.; Tagalpallewar, Amol

doi:10.1016/b978-0-12-822522-6.00002-3

Cited by 4 publications

(1 citation statement)

References 55 publications

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“…The decision on left or right nasal dominance was then con rmed using the Glatzel Mirror test 20 . Participants proceeded to self-administer either placebo or 24IU oxytocin by closing one nostril with their nger, tilting their head 32 and inhaling once, with a 30 second interval to allow for maximum absorption in either the dominant or non-dominant nostril. The selection of the nostril was pre-determined using a pseudo-randomised alternating design.…”

Section: Methodsmentioning

confidence: 99%

Nasal Dominance Potentiates Intranasal Oxytocin’s Anxiolytic Effects

Julius,

Nicholls,

Nowell

et al. 2024

Preprint

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The nasal cycle is a phenomenon whereby alterations in airflow alternate between left and right nostrils. During a nostril’s decongested – or dominant – state, the contralateral nostril is congested, or non-dominant. Intranasal oxytocin may elicit anxiolytic effects. To date, no study has investigated whether there is an optimal nasal pathway for oxytocin’s effects. Forty-four female adolescents aged 16 to 17 years were included in this exploratory study investigating effects of nasal dominance on intranasal oxytocin delivery. We show that intranasal oxytocin significantly reduces stress relative to placebo (p = 0.019, ηp2 = 0.129) and greater stress reduction occurs when oxytocin is delivered to the dominant, rather than non-dominant, nostril (p = 0.045, ηp2 = 0.102). We postulate that oxytocin administration may reduce stress and be most effective in the context of anxiolysis when administered to the dominant nostril. Further research investigating whether other intranasal psychotropic drugs have nostril-specific effects might benefit clinical practice.

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Section: Methodsmentioning

confidence: 99%

Nasal Dominance Potentiates Intranasal Oxytocin’s Anxiolytic Effects

Julius,

Nicholls,

Nowell

et al. 2024

Preprint

View full text Add to dashboard Cite

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Nose-to-brain drug delivery: Challenges and progress towards brain targeting in the treatment of neurological disorders

Raghav

Gupta

Awasthi

et al. 2023

Journal of Drug Delivery Science and Technology

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Formulation, design and strategies for efficient nanotechnology-based nasal delivery systems

Barros

Portugal

Batain

et al. 2022

RPS Pharmacy and Pharmacology Reports

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Objectives Nanotechnology-based nasal delivery systems have gained interest as a way of overcoming low drug bioavailability, limited brain exposure, fast metabolism and elimination, high doses, and unwanted side effects. The main benefits of intranasal administration include the non-invasive method, easy accessibility, porous epithelial barrier and highly vascularized tissue. However, it is imperative to identify interactions between the materials used and the nasal biological environment to ensure proper release. Methods Specific factors have been considered to comply with the strict nasal drug administration criteria. Given the broad interest in the nasal drug delivery system, this review summarizes ways to develop formulations for intranasal drug delivery and the main biopharmaceutical challenges. Key findings We have examined principal factors in nasal administration, such as physiological aspects of the nose, drug and biopharmaceutical properties, formulation properties, and nasal devices for drug delivery. Conclusions This review highlights new insights into different nanotechnology-based approaches for intranasal use and focuses on recent developments in topical nasal drug delivery systems (DDS), outlining the advantages and limitations of each system. The present article confines itself to research and novel concepts and the different strategies developed to increase bioavailability, safety, and a route to brain delivery.

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Physicochemical, biopharmaceutical, and practical considerations for efficient nose-to-brain drug delivery

Cited by 4 publications

References 55 publications

Nasal Dominance Potentiates Intranasal Oxytocin’s Anxiolytic Effects

Nasal Dominance Potentiates Intranasal Oxytocin’s Anxiolytic Effects

Nose-to-brain drug delivery: Challenges and progress towards brain targeting in the treatment of neurological disorders

Formulation, design and strategies for efficient nanotechnology-based nasal delivery systems

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