Physico‐chemical Properties and Bioactivities of a Glycoconjugate LbGp5B from Lycium barbarum L

Abstract

Keywords Lyciwn bar6onun 15. , glycoconjugate , activity * (~1 0 3 0 7 1 LI, L.T.; DONG, L.J.)

A review of botanical characteristics, phytochemistry, clinical relevance in efficacy and safety of Lycium barbarum fruit (Goji)

“…The LBP group has a molecular weight range of 8-241 kDa, and several LBP have been isolated and purified from aqueous L. barbarum extracts by methods such as DEAE ion-exchange cellulose, gel-permeation chromatography and high performance liquid chromatography (HPLC) (Luo, Yan, & Zhang, 2000;Ouyang, Li, & Xiao, 2007;Peng, Wang, & Tian, 2001;Tian & Wang, 2006). Their structural composition has been studied by SDS-PAGE gel electrophoresis, gas chromatography, amino acid automatic analysis, partial acid hydrolysis, periodate oxidation and nucleic magnetic resonance (NMR) spectrum regioselective enzymatic, alkaline and acidic hydrolyses and spectroscopic methods involving gas-chromatographic-mass-spectrometry (GCMS), high resolution electrospray ionization mass spectrometry (HRESIMS) and 1D and 2D NMR (Gao, Ali, & Khan, 2008), and they have been found to be complex glycopeptides consisting of acidic heteropolysaccharides and polypeptides or proteins.…”

Protective effect of Lycium barbarum polysaccharides on oxidative damage in skeletal muscle of exhaustive exercise rats

“…The earliest known Chinese medicinal monograph, documented medicinal use of L. barbarum around 2300 years ago. L. barbarum polysaccharides (LBP) isolated from the red-colored fruits are the most important functional factor [13][14][15][16][17][18]. Five L. barbarum polysaccharides (LbGp1-LbGp5) were separated and structurally elucidated [19].…”

Goji-Saft, ein neuer Wundertrank für Langlebigkeit und Wohlbefinden? Eine Übersicht zu Inhaltsstoffen, Pharmakologie, Wirkversprechen und Nutzen

“…LBP have been shown in several studies to promote splenocyte proliferation in vitro [14,15,43]. There are evidences that LBP act through enhanced expression of various cytokines and transcription factors.…”

“…They also strongly inhibited the AAPH (2,2'-azobis (2-amidinopropane) dihydrochloride)-induced hemolysis of erythrocytes. The glycoconjugate LbGp5B inhibits LDL oxidation in vitro [14]. LBP showed protective effects on heat-induced damages in rat testes in vivo and H 2 O-induced oxidative damage in mouse testicular cells in vitro [36].…”

“…The polysaccharide fraction consists of a complex mixture of highly branched and only partly characterized polysaccharides and proteoglycans, which is often referred to as Lycium barbarum polysaccharides or LBP. The glycosidic part accounts in most cases for about 90-95% of the mass and consists of arabinose, glucose, galactose, mannose, rhamnose, xylose and/or galacturonic acid [13][14][15][16].…”