Physical stability enhancement and antimicrobial properties of a sodium ionic cocrystal with theophylline

Abstract

In the present study, we have described the synthesis and characterisation of the theophylline hydrate (Theo hydrate), cocrystal (Theo–Phen·2H2O) and hydrated sodium co-crystal of theophylline (Na–(Theo)2ClO·2H2O), where Theo = theophylline and Phen = 1,10-phenathroline.

Crystallisation of organic hydrates by sublimation

“…S10, S12 and S14†) and TGA (Fig. S11, S13 and S15†), which showed that hydrates 2H-b , 28 3H-a 29 and 4H-a 25 were made using this method.…”

Enhancing the stability of active pharmaceutical ingredients by the cocrystal strategy

“…2c) that contribute to a significant stabilization of this hydrated sodium cocrystal (Na–(Theo) 2 –ClO·2H 2 O), compared with the traditional hydrated cocrystal without the participation of sodium (Theo–Phen·2H 2 O). 86 Furthermore, the employment of halogen-bond synthons in cocrystal design (Fig. 2d) also successfully transformed the highly volatile liquid iodoperfluoroalkanes into crystalline materials with long-term stability.…”

Virtual assessment achieved two binary cocrystals based on a liquid and a solid pyridine derivative with modulated thermal stabilities

“…[24][25][26] Its modulation has enabled the enhancement of the thermal stability and processability of the determined molecules through the formation of cocrystals. [27][28][29] Indeed, our group has previously studied the formation of cocrystals based on the acid⋯amide 30 and acid⋯pyridine heterosynthons 31 and the correlation of the crystal packing with their melting point values. 31 Therefore, aiming to extend our knowledge on the structure-property relationship of cocrystals focusing on the melting point, we have selected a liquid and a solid pyridine derivative (dPy), namely 4-acetylpyridine (4-Acpy) and 2-hydroxypyridine (2-OHpy), respectively.…”