Crystallisation of organic hydrates by sublimation

Abstract

Hydrates of organic molecules can be crystallised by sublimation if there is a strong hydrogen bond to water in the solid hydrate.

Synthesis of a Cocrystal Hydrate by Sublimation and Reversible Polymorphic Transformation through Single-Crystal to Single-Crystal Fashion

“…Indeed, sublimation and melt crystallization are the most convenient methods to prepare single crystals of certain compounds, especially for those host compounds which do not grow as single crystals without inclusion of a solvent molecule by solvent-mediated crystallization. , In melt crystallization, treatment of the melt phase in different ways can also generate different polymorphs of a material. , On the other hand crystals can be grown by sublimation under vacuum or at standard pressure. Mostly single-component material has been used to grow single crystals including the crystal of polymorphs. ,, Few multi-component compounds (salts and cocrystal) have been prepared by sublimation. − In a recent report Volkwyn and Haynes investigated the formation of organic hydrates of single-component solids by sublimation . However, there is no report on the preparation of single crystals of any multi-component hydrates by sublimation till date.…”

“…22−24 In a recent report Volkwyn and Haynes investigated the formation of organic hydrates of single-component solids by sublimation. 25 However, there is no report on the preparation of single crystals of any multicomponent hydrates by sublimation till date. Single-crystal to single-crystal (SCSC) transformation is a fascinating phenomenon in which molecules move in a cooperative manner without destroying single crystallinity.…”