Physical properties of root cementum: Part 9. Effect of systemic fluoride intake on root resorption in rats

Foo, Matthew; Jones, Alan R.; Darendeliler, M. Ali

doi:10.1016/j.ajodo.2005.02.030

Cited by 38 publications

(20 citation statements)

References 73 publications

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“…In this study, the volume of the root resorption craters was not zero in the control group, but was minimal in the 3 groups, even in rats that did not receive orthodontic force. Similar results were observed by Foo et al (2007). In the 60 g-ODN group, the volume of the root resorption craters was significantly lower than in the 60 g-NS group.…”

Section: Discussionsupporting

confidence: 78%

Effect of odanacatib on root resorption and alveolar bone metabolism during orthodontic tooth movement

et al. 2015

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ABSTRACT. The aim of this study was to investigate the effect of local administration of odanacatib (ODN) on orthodontic root resorption and the status of alveolar bone metabolism in rat molars. All specimens were scanned using microcomputed tomography and then the raw images were reconstructed. The total volume of the root resorption craters of the 60 g-NS (normal saline) group was higher than in the 60 g-ODN group and the control group. In the 60 g-NS group, the bone volume fraction values of alveolar bone were significantly decreased compared with the other 2 groups. There were no significant differences in the bone volume fraction values of the tibiae among the 3 groups. The results of tartrate-resistant acid phosphatase-positive (TRAP+) numbers showed that there was no difference between the 60 g-NS group and the 60 g-ODN group. The expression of cathepsin K was decreased significantly in the 60 g-ODN group. These results indicate that ODN reduces orthodontics-induced 17973 Effect of odanacatib on root resorption ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 17972-17981 (2015) external root resorption and increases alveolar bone metabolism. This may be because ODN inhibits the activity of odontoclasts, but maintains the quantity of odontoclasts and enhances bone formation. ODN promotes local alveolar bone metabolism, but does not affect systemic bone metabolism.

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Section: Discussionsupporting

confidence: 78%

Effect of odanacatib on root resorption and alveolar bone metabolism during orthodontic tooth movement

et al. 2015

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“…Foo et al reported that OIIRR was started by orthodontic tooth movement and that with a continuing force, cementum repair could not occur [20]. The appliance system used in this study produced a continuous force over the experimental period and moved the teeth orthodontically inducing root resorption.…”

Section: Discussionmentioning

confidence: 97%

The effects of low-level laser therapy on orthodontically induced root resorption

et al. 2015

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The aim of this study was to evaluate the preventive and/or reparative effects of low-level laser therapy (LLLT) on orthodontically induced inflammatory root resorption (OIIRR) in rats. Thirty rats were divided into four groups (short-term control (SC), short-term laser (SL), long-term control (LC), long-term laser (LL)). In all groups, the left first molar was moved mesially for 11 days. At the end of this period, the rats in groups SC and SL were killed in order to observe the resorption lacunas and to evaluate whether LLLT had any positive effect on root resorption. The groups LC and LL were remained for a healing period of 14 days in order to observe spontaneous repair of the resorption areas and investigate whether LLLT had reparative effects on root resorption. A Ga-Al-As diode laser (Doris, CTL-1106MX, Warsaw, Poland) with a wavelength of 820 nm was used. In SL group, the first molars were irradiated with the dose of 4.8 J/cm2 (50 mW, 12 s, 0.6 J) on every other day during force application. In LL group, the irradiation period was started on the day of appliance removal and the first molars were irradiated with the dose of 4.8 J/cm2 on every other day for the next 14 days. LLLT significantly increased the number of osteoblasts and fibroblasts, and inflammatory response in SL group in comparison with SC group (P = .001). The amount of resorption did not represent any difference between the two groups (P = .16). In LL group, LLLT significantly increased the number of fibroblasts and decreased the amount of resorption in comparison with LC group (P = .001; P = .02). Both parameters indicating the reparative and the resorptive processes were found to be increased by LLLT applied during orthodontic force load. LLLT applied after termination of the orthodontic force significantly alleyed resorption and enhanced/accelerated the healing of OIIRR. LLLT has significant reparative effects on OIIRR while it is not possible to say that it definitely has a preventive effect.

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“…One possible explanation might be the possibility of a reduction in the osteoclast population and activation that might reduce bone remodeling, leading to an increase in the hyalinization zone, which might amplify the resorptive processes. 17 This approach could explain why the experimental side of the high fluoride groups underwent a more pronounced resorptive activity during the retention period, especially under heavy force application.…”

Section: Discussionmentioning

confidence: 99%

“…16,[17][18][19] Foo et al 17 postulated that fluoride reduced the average amount of root resorption in rats. However, this effect was not statistically significant (P 5 .112).…”

Section: Discussionmentioning

confidence: 99%

Effect of fluoride on root resorption following heavy and light orthodontic force application for 4 weeks and 12 weeks of retention

Karadeniz

Gonzales

Türk

et al. 2012

The Angle Orthodontist

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Objective: To evaluate the null hypothesis that fluoride intake via drinking water has no effect on orthodontic root resorption in humans after orthodontic force application for 4 weeks and 12 weeks of retention. Materials and Methods: Forty-eight patients who required maxillary premolar extractions as part of their orthodontic treatment were selected from two cities in Turkey. These cities had a high and low fluoride concentration in public water of $2 pm and #0.05 pm, respectively. The patients were randomly separated into four groups of 12 each: group 1HH, high fluoride ($2 ppm) and heavy force (225 g); group 2LH, low fluoride (#0.05 ppm) and heavy force; group 3HL, high fluoride and light force (25 g); and group 4LL, low fluoride and light force. Light or heavy buccal tipping force was applied on the upper first premolars for 28 days. At day 28, the left premolars were extracted (positive control side); the right premolars (experimental side) were extracted after 12 weeks of retention. The samples were analyzed with microcomputed tomography. Results: On the positive control side, under heavy force application, the high fluoride groups exhibited less root resorption (P 5 .015). On the experimental side, it was found that fluoride reduced the total volume of root resorption craters; however, this effect was not statistically significant (P 5 .237). Moreover, the results revealed that under heavy force application experimental teeth exhibited more root resorption than positive control groups. Conclusion: The null hypothesis could not be rejected. High fluoride intake from public water did not have a beneficial effect on the severity of root resorption after a 4-week orthodontic force application and 12 weeks of passive retention. (Angle Orthod. 2013;83:418-424.)

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Physical properties of root cementum: Part 9. Effect of systemic fluoride intake on root resorption in rats

Cited by 38 publications

References 73 publications

Effect of odanacatib on root resorption and alveolar bone metabolism during orthodontic tooth movement

Effect of odanacatib on root resorption and alveolar bone metabolism during orthodontic tooth movement

The effects of low-level laser therapy on orthodontically induced root resorption

Effect of fluoride on root resorption following heavy and light orthodontic force application for 4 weeks and 12 weeks of retention

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