Effect of odanacatib on root resorption and alveolar bone metabolism during orthodontic tooth movement

Abstract

ABSTRACT. The aim of this study was to investigate the effect of local administration of odanacatib (ODN) on orthodontic root resorption and the status of alveolar bone metabolism in rat molars. All specimens were scanned using microcomputed tomography and then the raw images were reconstructed. The total volume of the root resorption craters of the 60 g-NS (normal saline) group was higher than in the 60 g-ODN group and the control group. In the 60 g-NS group, the bone volume fraction values of alveolar bone were significantly decreased compared with the other 2 groups. There were no significant differences in the bone volume fraction values of the tibiae among the 3 groups. The results of tartrate-resistant acid phosphatase-positive (TRAP+) numbers showed that there was no difference between the 60 g-NS group and the 60 g-ODN group. The expression of cathepsin K was decreased significantly in the 60 g-ODN group. These results indicate that ODN reduces orthodontics-induced 17973 Effect of odanacatib on root resorption ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 17972-17981 (2015) external root resorption and increases alveolar bone metabolism. This may be because ODN inhibits the activity of odontoclasts, but maintains the quantity of odontoclasts and enhances bone formation. ODN promotes local alveolar bone metabolism, but does not affect systemic bone metabolism.

The effect of cathepsin K inhibitor surface treatment on delayed tooth replantation in dogs

“…Moreover, the relatively young age of the experimental dogs may have exacerbated this effect because inflammatory root resorption can occur rapidly in young teeth with wide dentinal tubules. 27 Unlike sodium fluoride, enamel matrix derivative, or bisphosphonates, which are applied once topically on the root to exert their effects, ODN may require different frequencies and modes of application for optimal results. 10,11,25 However, ODN exhibits no such characteristics and its single application before replantation may be insufficient to properly affect the healing process of the replanted tooth.…”

“…Other in vivo studies investigating the effect of ODN in the field of dentistry, although not concerned with replantation of avulsed teeth, administered ODN orally and periodically, 17,26 or injected it into the periodontium every 3 days. 27 Unlike sodium fluoride, enamel matrix derivative, or bisphosphonates, which are applied once topically on the root to exert their effects, ODN may require different frequencies and modes of application for optimal results.…”

Role of odanacatib in reducing bone loss due to endodontic disease: An overview

“…It does not decrease the number of osteoclasts[ 36 ] rather decreases the magnitude of bone resorption and maintains the bone formation at the same time. [ 9 37 ] It selectively inhibits proteolysis of matrix protein by CtsK, without affecting other osteoclast activities or viability,[ 38 ] with simultaneous inhibition of inflammation. This in turn decreases osteoclast activation and differentiation, which shows a promising therapeutic method on periapical inflammatory disease.…”

An Extensive Review of Literature: Considering Bone Reaction To Different Agents In Orthodontically Induced Root And Alveolar Resorption

“…Therefore, H(1) receptor antagonists could interfere with orthodontic treatment. 47 Another study made acomparison between three possible osteoporotic treatments in theprevention of glucocorticoidinduced alveolar bone loss. Result presented histopathologically the glucocorticoid group showed wide medullary cavities with wide osteocytic lacunae.…”