Physical properties and antibacterial activity of chitosan/acemannan mixed systems

Escobedo-Lozano, Amada Yerén; Domard, Alain; Velázquez, Carlos; Goycoolea, Francisco M.; Argüelles‐Monal, Waldo

doi:10.1016/j.carbpol.2014.07.064

Cited by 34 publications

(13 citation statements)

References 44 publications

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“…Therefore, cell wall of bacteria was destabilized, inducing leakage of cellular content and ultimately bacteria death (Qin et al 2006). The difference on inhibition activity of chitosan to gram-positive bacteria and gram-negative bacteria may be due to the structural differences of cell walls (Escobedo-Lozano et al 2015). For gram-positive bacteria, chitosan can form a layer around the cells and the inhibition activity was enhanced with the increase of chitosan MW.…”

Section: Biological Propertiesmentioning

confidence: 96%

Drug Delivery Applications of Chitosan and its Derivatives

Zhang

Mao

2015

Excipient Applications in Formulation Design and Drug Delivery

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The development of drug delivery systems always goes hand in hand with the advancement of material science. The novel synthetic or natural functional materials provide opportunities to design optimal drug delivery systems. Among these, chitosan and its derivatives exhibit excellent application future because of its prominent characteristics. In this chapter, research progress of chitosan and its derivatives for drug delivery, from structure to properties, from properties to its application were overviewed. The physicochemical properties, biological properties, biodegradability, safety evaluation and structure modification of chitosan were introduced. Furthermore, applications of chitosan and its derivatives in drug delivery including as the carrier of nanoparticles and microparticles, as coating material, as matrix of hydrogels, films and sustained release tablets, as stabilizers, as absorption enhancers, were discussed. Finally, the applications of chitosan and its derivatives in different administration routes, and their advantages for gene, protein and vaccine delivery, were reviewed. The numerous successful studies on exploitation and application of chitosan and its derivatives showed promising application future of these materials in drug delivery.

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Section: Biological Propertiesmentioning

confidence: 96%

Drug Delivery Applications of Chitosan and its Derivatives

Zhang

Mao

2015

Excipient Applications in Formulation Design and Drug Delivery

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“…Aloe vera gel is the clear, jelly-like substance found in the inner part of the aloe leaf with anti-inflammatory,[32] antimicrobial,[333435] antiulcer effects. [36]…”

Section: Introductionmentioning

confidence: 99%

Comparison the efficacy of herbal mouthwash with chlorhexidine on gingival index of intubated patients in Intensive Care Unit

Rezaei

Mahboubi³

et al. 2016

J Indian Soc Periodontol

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Background:Intubated patients in Intensive Care Unit (ICU) are not able to take care of their mouth health, so they are at risk of bacterial colonization and dental plaques formation that can lead to systemic diseases such as pneumonia and gingivitis.Aims:In randomized, double-blind clinical study, the efficacy of natural herbal mouthwash containing Salvadora persica ethanol extract and Aloe vera gel was compared with chlorhexidine on gingival index (GI) of intubated patients in ICU.Materials and Methods:Seventy-six intubated patients (18–64 years old with mean age 40.35 ± 13.2) in ICU were admitted to this study. The patients were randomly divided into two groups: (1) Herbal mouthwash and (2) chlorhexidine solution. Before the intervention, the GIs was measured by modified GI device into two groups. The mouth was rinsed by mouthwashes every 2–3 h for 4 days. 2 h after the last intervention, GIs were determined.Results:Along with mechanical methods, herbal mouthwash in reducing GI was statistically significant than that of chlorhexidine (P < 0.05).Conclusion:The results of this study introduce a new botanical extract mouthwash with dominant healing effects on GI (1.5 ± 0.6) higher than that of synthetic mouthwash, chlorhexidine (2.31 ± 0.73).

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“…Thus, the study of nanoparticles based on organic compounds (ONPs) has become an interesting topic. Nevertheless, reports on ONPs in the literature are limited, and most of them are focused on polymers, such as chitosan NPs [ 27 , 28 , 29 ]. The electronic/optical properties of ONPs are important because their van der Waals intermolecular forces, hydrogen-bonding interactions, and electrostatic attractions are fundamentally different from those of inorganic metals or semiconductors [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

Organic-Inorganic Hybrid Nanoparticles for Bacterial Inhibition: Synthesis and Characterization of Doped and Undoped ONPs with Ag/Au NPs

et al. 2015

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Organic nanoparticles (ONPs) of lipoic acid and its doped derivatives ONPs/Ag and ONPs/Au were prepared and characterized by UV-Visible, EDS, and TEM analysis. The antibacterial properties of the ONPs ONPs/Ag and ONPs/Au were tested against bacterial strains (Staphylococcus aureus, Bacillus cereus, Escherichia coli and Salmonella typhi). Minimal Inhibitory Concentration (MIC) and bacterial growth inhibition tests show that ONPs/Ag are more effective in limiting bacterial growth than other NPs, particularly, for Gram positive than for Gram-negative ones. The order of bacterial cell growth inhibition was ONPs/Ag > ONPs > ONPs/Au. The morphology of the cell membrane for the treated bacteria was analyzed by SEM. The nature of bond formation of LA with Ag or Au was analyzed by molecular orbital and density of state (DOS) using DFT.

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Physical properties and antibacterial activity of chitosan/acemannan mixed systems

Cited by 34 publications

References 44 publications

Drug Delivery Applications of Chitosan and its Derivatives

Drug Delivery Applications of Chitosan and its Derivatives

Comparison the efficacy of herbal mouthwash with chlorhexidine on gingival index of intubated patients in Intensive Care Unit

Organic-Inorganic Hybrid Nanoparticles for Bacterial Inhibition: Synthesis and Characterization of Doped and Undoped ONPs with Ag/Au NPs

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