Physical Map of 17p13 and the Genes Adjacent to p53

A physical and expression map of the D17S1810–D17S1353 region spanning the central areolar choroidal dystrophy locus

“…These include STS-F16600, phospholipase D2 (PLD2), oxoglutarate transporter (SLC25A11), enolase 3 (ENO3), CD42B, A008B35, SHGC-31370, WI-18497, human homolog of the Drosophila period gene (PER1), vesicle associated membrane protein-2 (VAMP2) and serine-threonine kinase 12 (STK12). These results supported previous observations (Cousin et al, 2000). All of these markers were located on the centromeric site of our region.…”

“…The recent map by Cousin and co-workers (Cousin et al, 2000) overlaps only in the TP53 region and shows minor inconsistencies with our map. Our results place ALOX12 approximately 350-400 kb upstream from TP53, between DLG4 (previously known as PSG95) and WI-13565 (Figs.…”

A Soluble Form of B Cell Maturation Antigen, a Receptor for the Tumor Necrosis Factor Family Member April, Inhibits Tumor Cell Growth

“…High levels of APRIL mRNA expression have been described in carcinomas 12, a tumor class in which mutations in the tumor suppressor p53 gene are frequently found 13. As APRIL is localized on chromosome 17p13.1, 130–150 kb telomeric to p53 14, it is conceivable that an increased local transcriptional activity may contribute to augment APRIL expression. We cannot rule out, however, that the action of BCMA–Fc is indirect.…”

The human FGF gene family: chromosome location and phylogenetic analysis

“…Interestingly, highly related copies of FGF7, located on chromosome 15q15 → q21.1 (Zimonjic et al, 1997), were identified on chromosomes 1q32.3, 9p21.3, 9q12, 15q15.2, 18p11.21, and 21p11.2 (Table 1). The FGF11 gene was localized on chromosome 17p13 by physical mapping (Smallwood et al, 1996;Cousin et al, 2000). Additional copies of FGF11 were found on chromosomes 17q25.3 and 9q21.1.…”