The human FGF gene family: chromosome location and phylogenetic analysis

Hs, Kim

doi:10.1159/000056965

Cited by 12 publications

(5 citation statements)

References 6 publications

(6 reference statements)

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“…The first phylogeny-based classifications of the gene family were proposed before the whole complement of FGF genes was described in mammals which led to incomplete conclusions [5, 8]. The first phylogenetic studies including all the mammalian FGFs proposed a division of the gene family into six [9] or seven [6] subfamilies. In 2005, Popovici and collaborators performed the first study including both protostome and deuterostome FGFs as well as FGFs from baculoviruses, an arthropod-specific group of viruses [4].…”

Section: Introductionmentioning

confidence: 99%

Evolution of the FGF Gene Family

Oulion

Bertrand

Escrivà

2012

International Journal of Evolutionary Biology

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Fibroblast Growth Factors (FGFs) are small proteins generally secreted, acting through binding to transmembrane tyrosine kinase receptors (FGFRs). Activation of FGFRs triggers several cytoplasmic cascades leading to the modification of cell behavior. FGFs play critical roles in a variety of developmental and physiological processes. Since their discovery in mammals, FGFs have been found in many metazoans and some arthropod viruses. Efforts have been previously made to decipher the evolutionary history of this family but conclusions were limited due to a poor taxonomic coverage. We took advantage of the availability of many new sequences from diverse metazoan lineages to further explore the possible evolutionary scenarios explaining the diversity of the FGF gene family. Our analyses, based on phylogenetics and synteny conservation approaches, allow us to propose a new classification of FGF genes into eight subfamilies, and to draw hypotheses for the evolutionary events leading to the present diversity of this gene family.

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Section: Introductionmentioning

confidence: 99%

Evolution of the FGF Gene Family

Oulion

Bertrand

Escrivà

2012

International Journal of Evolutionary Biology

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“…Receptor binding studies have shown that FGFR4 but not FGFR1c or FGFR2c can serve as a receptor for FGF16 (Konishi et al, 2000). The potential for binding of FGF16 to FGFR3c was not tested in this study; however, given that FGF9, which is one of the FGFs most closely related to FGF16, activates FGFR3c, it would not be surprising if the same were true for FGF16 (Ornitz et al, 1996; Kim, 2001). Our expression analysis, moreover, shows that Fgfr3c is localized appropriately to serve as an FGF16 receptor.…”

Section: Discussionmentioning

confidence: 99%

Expression of mouse fibroblast growth factor and fibroblast growth factor receptor genes during early inner ear development

Wright

Hatch

Karabağlı

et al. 2003

Developmental Dynamics

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The inner ear, which mediates hearing and equilibrium, develops from an ectodermal placode located adjacent to the developing hindbrain. Induction of the placode and its subsequent morphogenesis and differentiation into the inner ear epithelium and its sensory neurons, involves signalling interactions within and between otic and non-otic tissues. Several members of the fibroblast growth factor (FGF) family play important roles at various stages of otic development; however, there are additional family members that have not been evaluated. In this study, we surveyed the expression patterns of 18 mouse Fgf and 3 Fgf receptor (Fgfr) genes during early otic development. Two members of the Fgf family, Fgf4 and Fgf16, and all three tested members of the Fgfr family, Fgfr2c, Fgfr3c, and Fgfr4, were expressed in tissues relevant to inner ear development. Fgf4 transcripts were expressed in the preplacodal and placodal ectoderm, suggesting potential roles in placode induction and/or maintenance.

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“…Families A, B, C, D, E, F, and G are also designated 1, 4, 3, 8, 9, 11, and 19, respectively, in other nomenclatures. (21,31) The species whose sequences have been studied here are in blue. The tree is roughly similar to those previously reported by us, (20) Kim et al, (21) Satou et al (22) and Itoh and Ornitz, (23) and shows that the FGF superfamily can be divided in eight evolutionary divergent families ( Fig.…”

Section: Phylogeny Of the Fgf Superfamilymentioning

confidence: 99%

An evolutionary history of the FGF superfamily

et al. 2005

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Fibroblast growth factors (FGF) are associated with multiple developmental and metabolic processes in triploblasts, and perhaps also in diploblasts. The evolution of the FGF superfamily has accompanied the major morphological and functional innovations of metazoan species. The study of FGFs throughout species shows that the FGF superfamily can be subdivided in eight families in present-day organisms and has evolved through phases of gene duplications and gene losses. At least two major expansions of the superfamily can be recognized: a first expansion increased the number of FGFs from one or few archeo-FGFs to eight proto-FGFs, prototypic of the eight families. A second expansion, which took place during euchordate evolution, is associated with genome duplications. It increased the number of members in the families. Subsequent losses reduced that number to the present-day figures.

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The human FGF gene family: chromosome location and phylogenetic analysis

Cited by 12 publications

References 6 publications

Evolution of the FGF Gene Family

Evolution of the FGF Gene Family

Expression of mouse fibroblast growth factor and fibroblast growth factor receptor genes during early inner ear development

An evolutionary history of the FGF superfamily

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