Physical Incompatibility between Parenteral Cloxacillin and Vancomycin

Chan, Alice; Tawfik, Gerda; Cheng, Wilson

doi:10.4212/cjhp.v66i5.1290

Cited by 2 publications

(2 citation statements)

References 4 publications

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“…8 Sianokobalamin juga kompatibel dengan vitamin B. 17 Belum ada penelitian mengenai pencampuran vitamin ini dengan ringer laktat. Pada observasi peneliti, tidak ada perubahan kompatibilitas pada hasil pencampuran.…”

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Effect of Pharmaceutical Care in Patients with Cardiovascular Risk in Community

Rochmawati

Queljoe

Dewi

et al. 2014

Indones J Clin Pharm

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AbstrakPencampuran sediaan parenteral (iv admixture) yang sudah dilaksanakan secara umum di rumah sakit mempunyai kemungkinan terjadinya kegagalan baik berupa inkompatibilitas obat maupun gangguan stabilitas obat. Penelitian ini bertujuan mengetahui angka inkompatibilitas obat dalam pencampuran sediaan parenteral di RSUD Prof. Dr. Margono Soekarjo Purwokerto yang mengalami inkompatibilitas fisika yang teramati secara organoleptis. Penelitian ini merupakan penelitian deskriptif prospektif. Data yang telah dikumpulkan lalu dianalisis secara deskriptif. Dari 667 pencampuran sediaan parenteral di bangsal bedah saraf RSUD Prof. Dr. Margono Soekarjo selama bulan Februari 2010, dapat disimpulkan angka inkompatibilitas potensial sebesar 0,45% dan inkompatibilitas aktual sebesar 2,55%. Inkompatibilitas aktual yang terjadi berupa kristal 0,17%, endapan 0,17%, dan kabut sementara 2,04% pada pencampuran fenitoin dengan NaCl atau ringer laktat. However, it has a possibility of failures, like incompatibilities and changes in drug stabilities. The aim of this study was to determine the rate of drug incompatibilities in mixing parenteral preparations in neurosurgery ward in Prof. Dr. Margono Soekarjo Regional Public Hospital which undergo physical incompatibility observed in organoleptic. This study was a prospective descriptive research for one month period. Data were collected and analyzed descriptively. The results showed that from 667 parenteral admixtures in neurosurgery ward in Prof Dr Margono Soekarjo Hospital in February 2010, there were 0.45% potential incompatibility and 2.55% actual incompatibility happened. Actual incompatibility shown as crystal 0.17%, sediment 0.17%, and 2.04% was non-permanent haze in phenytoin and sodium chloride or ringer lactate admixtures.

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“…17 Selain inkompatibilitas antara obat-obat, inkompatibilitas nutrisi parenteral juga dapat menjadi permasalahan lain yang dapat menganggu efektivitas terapi. 18,19 Simpulan Pencampuran sediaan parenteral di bangsal bedah saraf rumah sakit umum daerah Prof. Dr. Margono Soekarjo menghasilkan inkompatibilitas potensial sebesar 0,45% dan inkompatibilitas aktual sebesar 2,55%.…”

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Effect of Pharmaceutical Care in Patients with Cardiovascular Risk in Community

Rochmawati

Queljoe

Dewi

et al. 2014

Indones J Clin Pharm

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Physical Incompatibility between Vancomycin and Viscoelastic Mimicking Acute Endophthalmitis: The First Report

Elabjer

Šarić

Bušić

et al. 2019

Case Reports in Ophthalmological Medicine

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This is the first documentation of vancomycin precipitation with viscoelastic in the anterior chamber of the eye. A 34-year-old white male underwent uneventful penetrating keratoplasty. Intracameral instillation of 1 mg/0.1 mL of vancomycin followed no attempts of meticulous viscoelastic irrigation. Six hours later thick white material in the anterior chamber was sedimented. The following criteria excluded the diagnosis of endophthalmitis and TASS: clear and transparent anterior chamber and vitreous body, the absence of ciliary injection and corneal oedema, and unremarkable laboratory tests’ results. This iatrogenic complication mimicking endophthalmitis does not require any specific management and should be acknowledged in guidelines for prevention and treatment of endophthalmitis. The objective of this paper is to alert colleagues to this iatrogenic complication of vancomycin mimicking endophthalmitis. Whether this condition should be labelled as positive or negative demands further investigation. As vancomycin is a time-dependent antibiotic, it is possible that this precipitate could serve as a slowly releasing drug depot and viscoelastic as a vehicle for precipitation. This being the case, investigation is needed to analyse its potential to precipitate with another dispersive and cohesive viscoelasticity.

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Physical Incompatibility between Parenteral Cloxacillin and Vancomycin

Cited by 2 publications

References 4 publications

Effect of Pharmaceutical Care in Patients with Cardiovascular Risk in Community

Effect of Pharmaceutical Care in Patients with Cardiovascular Risk in Community

Physical Incompatibility between Vancomycin and Viscoelastic Mimicking Acute Endophthalmitis: The First Report

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