DNA sequence analysis of the nuclear ribosomal internal transcribed spacer (ITS) region was exploited for its applications in the authentication of Sauropus androgynus (L.) Merr. as raw-material herbal medicine and supplement. Leaf samples from 12 different geographic locations in Indonesia were collected. Twelve DNA sequences from the samples were analysed. The sequences were trimmed before sequence alignment. The sequences ranged from 626 to 664 bp in length after trimming. Based on the multiple sequence alignment, a phylogenetic tree was generated using the MrBayes program. It consisted of two groups: one group comprised sequences from Trawas and the other one comprised sequences from Batu, Trawas and Surabaya. These results strongly suggest that ITS sequence analysis is a valuable tool for distinguishing intraspecific differences among S. androgynus cultivars from Indonesia.
AbstrakPencampuran sediaan parenteral (iv admixture) yang sudah dilaksanakan secara umum di rumah sakit mempunyai kemungkinan terjadinya kegagalan baik berupa inkompatibilitas obat maupun gangguan stabilitas obat. Penelitian ini bertujuan mengetahui angka inkompatibilitas obat dalam pencampuran sediaan parenteral di RSUD Prof. Dr. Margono Soekarjo Purwokerto yang mengalami inkompatibilitas fisika yang teramati secara organoleptis. Penelitian ini merupakan penelitian deskriptif prospektif. Data yang telah dikumpulkan lalu dianalisis secara deskriptif. Dari 667 pencampuran sediaan parenteral di bangsal bedah saraf RSUD Prof. Dr. Margono Soekarjo selama bulan Februari 2010, dapat disimpulkan angka inkompatibilitas potensial sebesar 0,45% dan inkompatibilitas aktual sebesar 2,55%. Inkompatibilitas aktual yang terjadi berupa kristal 0,17%, endapan 0,17%, dan kabut sementara 2,04% pada pencampuran fenitoin dengan NaCl atau ringer laktat. However, it has a possibility of failures, like incompatibilities and changes in drug stabilities. The aim of this study was to determine the rate of drug incompatibilities in mixing parenteral preparations in neurosurgery ward in Prof. Dr. Margono Soekarjo Regional Public Hospital which undergo physical incompatibility observed in organoleptic. This study was a prospective descriptive research for one month period. Data were collected and analyzed descriptively. The results showed that from 667 parenteral admixtures in neurosurgery ward in Prof Dr Margono Soekarjo Hospital in February 2010, there were 0.45% potential incompatibility and 2.55% actual incompatibility happened. Actual incompatibility shown as crystal 0.17%, sediment 0.17%, and 2.04% was non-permanent haze in phenytoin and sodium chloride or ringer lactate admixtures.
Background: The quality of life of coronary heart disease (CHD) patients can be improved by increasing patient compliance with treatment and health literacy rates. Over the past decade, mobile health (mHealth) has improved treatment adherence and demonstrated strong potential to increase health literacy rates. Objectives: Analyse the effect of “Friends of Heart” application on the compliance and knowledge of coronary heart disease patients. Methods: A randomised controlled trial (RCT) was conducted. The test group (intervention group) used the Sahabat Jantung/ “Friends of Heart” application developed for the Android 4.1 operating system, while the control group did not. Compliance was measured for 30 days in outpatient settings; it included pill count and time deviations in taking medication. Knowledge was assessed using questionnaires. Results: Statistical results showed significant differences in knowledge and adherence between the intervention and the control group (p = 0.0001). Conclusion: The use of the “Friends of Heart” application could improve compliance and knowledge of coronary heart disease patients.
Antiplatelets are medicines that stop cells in the blood (platelets) from sticking together and forming a clot, which may lead to a heart attack or stroke. Furthermore, the use of antiplatelet after percutaneous coronary intervention is one of the challenge encountered by the clinicians or hospital staff because it has to be calculated between the risk-benefit ratio. This study aims to evaluate the use of dual antiplatelet therapy in patients undergoing percutaneous coronary intervention. A retrospective study was used and data were obtained from patient records. The data obtained were analysed to know the relationship between age, gender, and type of drug combination associated with ischemic events. The patient demographics were analysed descriptively, and the comparison between age and sex group related to ischemic events was analysed using chi-square analysis. There was no statistical difference in ischemic events between age and sex group. The study reported that the most commonly used DAPT profile was the combination of Aspirin 100 mg - Clopidogrel 75 mg (38%) and Aspirin 100 mg - Ticagrelor 90 mg (28%). The profile of ischemic events in patients using the aspirin-clopidogrel combination was lower than that of the aspirin-ticagrelor combination.Keywords: Antiplatelet, Percutaneous Coronary Intervention, Coronary Heart Disease
Antiplatelet is the most commonly drug used as secondary prevention for Coronary Heart Disease (CHD). The aim of this study was to determine the profile of the use of antiplatelet related with its efficacy and side effects. Observational methods with cross sectional approach for 3 months follow up was used, a descriptive analysis carried out at the private hospital in Surabaya. Results from this study: aspirin 80 mg was the most prescribed antiplatelet in patients with the incidence of ischemic events 9%. Higher ischemic events also seen in patients with hypertension, dyslipidemia, and Diabetes Mellitus. Bleeding and gastrointestinal disturbance as side effects occurred in 4 patients who used aspirin as antiplatelet, and based for Naranjo scale can be concluded as possible adverse drug reaction. Keywords: Coronary Heart Disease, Antiplatelet , Ischemic events, Bleeding
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