Physical–chemical characterization of N-acylhydrazone derivative chitosan films using spectroscopic and thermoanalytical techniques

Wanderley, Davidson Marrony Santos; Melo, Demis Ferreira de; Silva, Laryssa M.; Silva, Wesley C.; Correia, Lidiane Pinto; Oshiro, João Augusto; Fook, Marcus Vinícius Lia; Moura, Ricardo Olímpio de; Lima, Rosemary Sousa Cunha; Damasceno, Bolívar Ponciano Goulart de Lima

doi:10.1007/s10973-019-08906-1

Cited by 7 publications

(8 citation statements)

References 29 publications

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“…The diffractogram of JR19 shows diffraction peaks at 8.54°, 12.80°, 14.09°, 16.08°, 18.19°, 22.65°, 23.59°, 24.53°, 25.70°, 28.16° and 30.27° 2θ, characterizing the crystalline nature of this compound. For the physical mixture of ACT and JR19, the diffraction peaks of the latter appear with less intensity, which is in accordance with the findings of Wanderley et al [59].…”

Section: X-ray Diffraction (Xrd)supporting

confidence: 92%

“…This finding indicates an amorphization of the structure, which might due to the long interatomic distances of the glycosidic bonds that link the 2θ, characterizing the crystalline nature of this compound. For the physical mixture of ACT and JR19, the diffraction peaks of the latter appear with less intensity, which is in accordance with the findings of Wanderley et al [59].…”

Section: X-ray Diffraction (Xrd)supporting

confidence: 92%

“…The FTIR spectra of JR19 show a characteristic band attributed to C≡N (2279 to 2264 cm −1 ), as previously reported by Moraes et al [19], Pandey, Khan and Saxena [56], Ke et al [57] and Konnola,Nair and Joseph [58]. This nitrile stretch band was also present in the FTIR spectra of physical mixture and, to a lesser extent, in that of JR19F, which suggests some interaction between JR19 and ACT as demonstrated by Wanderley et al [59] in chitosan films entrapped with JR19.…”

Section: Fourier Transform Infrared Spectroscopy (Ftir)supporting

confidence: 81%

“…The appearance of these peaks may be related to the presence of a new crystalline form of JR19 obtained during the preparation of JR19F that probably modified its crystalline pattern. Wanderley et al [59] obtained similar results after the incorporation of JR19 in chitosan films. In fact, physical-chemical interactions between polymer and drug are likely to occur, which might result in the loss, decrease or change in the crystallinity of the drug.…”

Section: X-ray Diffraction (Xrd)mentioning

confidence: 68%

“…This band appears at high intensity in the spectrum of JR19 and ACT + JR19 (physical mixture); however, it appears at a lower intensity in the spectra of JR19F. Such finding might indicate that the polymer had some influence on the drug during the film formation process [ 59 ].…”

Section: Resultsmentioning

confidence: 99%

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N-acylhydrazone Derivative-Loaded Cellulose Acetate Films: Thermoanalytical, Spectroscopic, Mechanical and Morphological Characterization

et al. 2021

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Cellulose acetate (ACT) is one of the most important cellulose derivatives due to its biodegradability and low toxicity, presenting itself as one of the main substitutes for synthetic materials in the development of wound dressing films. The incorporation of a N-acylhydrazonic derivative (JR19), with its promising anti-inflammatory activity, may represent an alternative for the treatment of skin wounds. This work aims to develop and to physicochemically and mechanically characterize ACT films containing JR19. The films were prepared using the ‘casting’ method and further characterized by thermoanalytical and spectroscopic techniques. In addition, mechanical tests and morphological analysis were performed. Thermogravimetry (TG) and differential scanning calorimetry (DSC) analyses showed that the thermal events attributed to excipients and films were similar, indicating the absence of physical incompatibilities between ACT and JR19. Infrared spectroscopy showed that JR19 was incorporated into ACT films. The characteristic band attributed to C≡N (2279 to 2264 cm−1) was observed in the spectra of JR19, in that of the physical mixture of JR19/ACT, and, to a lesser extent, in the spectra of JR19 incorporated into the ACT film, suggesting some interaction between JR19 and ACT. X-ray diffraction (XRD) evidenced the suppression of the crystallinity of JR19 (diffraction peaks at 8.54°, 12.80°, 14.09°, 16.08°, 18.19°, 22.65°, 23.59°, 24.53°, 25.70°, 28.16° and 30.27°2θ) after incorporation into ACT films. The mechanical tests indicated the adequate integrity of the films and their resistance to bending. The morphological characterization showed JR19 crystals along with a homogeneously distributed porous structure throughout the surface of the films with an average diameter of 21.34 µm and 22.65 µm of the films alone and of those incorporating JR19F, respectively. This study was able to characterize the ACT films incorporating JR19, showing their potential to be further developed as wound healing dressings.

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Section: X-ray Diffraction (Xrd)supporting

confidence: 92%

Section: X-ray Diffraction (Xrd)supporting

confidence: 92%