Biocompatibility and mechanical properties evaluation of chitosan films containing an N-acylhydrazonic derivative

Wanderley, Davidson Marrony Santos; Melo, Demis Ferreira de; Silva, Laryssa M.; Souza, José W.L.; Pina, Hermano V.; Lima, Daniel B.; Amoah, Solomon Kweku Sagoe; Borges, Silvia M. P.; Fook, Marcus Vinícius Lia; Moura, Ricardo Olímpio de; Lima, Rosemary Sousa Cunha; Damasceno, Bolívar Ponciano Goulart de Lima

doi:10.1016/j.ejps.2020.105547

Cited by 7 publications

(8 citation statements)

References 34 publications

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“…The JR19Fs kept their integrity up to an average of 372 bends, while the BFs showed resistance to an average of 348 bends. These results corroborate the data shown by Wanderley et al [ 29 ], who demonstrated that the presence of JR19 influenced the physicochemical properties of chitosan films, promoting greater resistance to bending the films.…”

Section: Resultssupporting

confidence: 92%

“…This increase in Ra for JR19F together with the reduction in crystal size may favor the solubility of JR19 in aqueous media, as the increase in Ra is directly related to the increase in the hydrophilic character of a material [ 46 , 47 ]. The 3D images of the films ( Figure 3 ) confirm this difference in the surfaces between BF and JR19F, as evidenced by the greater number of valleys in the JR19F ( Figure 3 B) in relation to BF ( Figure 3 A), which is in accordance to the findings reported by Wanderley et al [ 29 ].…”

Section: Resultssupporting

confidence: 90%

“…This increase in Ra of JR19F in relation to BF may be directly related to the increase in pore size, as found by Rahimpour et al [ 45 ]. These values follow the same trend shown by Wanderley et al [ 29 ], in which chitosan films with JR19 showed higher Ra values (9.9 µm) compared to chitosan films without this drug (3.71 µm).…”

Section: Resultssupporting

confidence: 89%

“…The differences between the surface morphology of BF and JR19F are better evidenced in the micrographs taken at magnitude of 1120× ( Figure 2 B,D), where it is possible to visualize the presence of cylindrical crystals dispersed on the surface of JR19F. Such crystals are similar to those of JR19, which are depicted in Figure 2 E. This finding is similar to that presented by Wanderley et al [ 29 ], in which the presence of JR19 crystals in polymeric chitosan films could be visualized. The presence of these crystals in JR19F samples seems to indicate that JR19 was successfully incorporated into the ACT films.…”

Section: Resultssupporting

confidence: 87%

“…Such crystals are similar to those of JR19, which are depicted in Figure 2E. This finding is similar to that presented by Wanderley et al [29], in which the presence of JR19 crystals in polymeric chitosan films could be visualized. The presence of these crystals in JR19F samples seems to indicate that JR19 was successfully incorporated into the ACT films.…”

Section: Optical Microscopysupporting

confidence: 91%

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N-acylhydrazone Derivative-Loaded Cellulose Acetate Films: Thermoanalytical, Spectroscopic, Mechanical and Morphological Characterization

et al. 2021

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Cellulose acetate (ACT) is one of the most important cellulose derivatives due to its biodegradability and low toxicity, presenting itself as one of the main substitutes for synthetic materials in the development of wound dressing films. The incorporation of a N-acylhydrazonic derivative (JR19), with its promising anti-inflammatory activity, may represent an alternative for the treatment of skin wounds. This work aims to develop and to physicochemically and mechanically characterize ACT films containing JR19. The films were prepared using the ‘casting’ method and further characterized by thermoanalytical and spectroscopic techniques. In addition, mechanical tests and morphological analysis were performed. Thermogravimetry (TG) and differential scanning calorimetry (DSC) analyses showed that the thermal events attributed to excipients and films were similar, indicating the absence of physical incompatibilities between ACT and JR19. Infrared spectroscopy showed that JR19 was incorporated into ACT films. The characteristic band attributed to C≡N (2279 to 2264 cm−1) was observed in the spectra of JR19, in that of the physical mixture of JR19/ACT, and, to a lesser extent, in the spectra of JR19 incorporated into the ACT film, suggesting some interaction between JR19 and ACT. X-ray diffraction (XRD) evidenced the suppression of the crystallinity of JR19 (diffraction peaks at 8.54°, 12.80°, 14.09°, 16.08°, 18.19°, 22.65°, 23.59°, 24.53°, 25.70°, 28.16° and 30.27°2θ) after incorporation into ACT films. The mechanical tests indicated the adequate integrity of the films and their resistance to bending. The morphological characterization showed JR19 crystals along with a homogeneously distributed porous structure throughout the surface of the films with an average diameter of 21.34 µm and 22.65 µm of the films alone and of those incorporating JR19F, respectively. This study was able to characterize the ACT films incorporating JR19, showing their potential to be further developed as wound healing dressings.

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Section: Resultssupporting

confidence: 92%