Physical Activity Improves Lipid and Weight‐Loss Outcomes After Metabolic Bariatric Surgery in Adolescents with Severe Obesity

Price, Paula Holland; Kaizer, Alexander M.; Daniels, Stephen R.; Jenkins, Todd M.; Inge, Thomas H.; Eckel, Robert H.

doi:10.1002/oby.22475

Cited by 14 publications

(10 citation statements)

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“…The methods used for data collection have been previously described ( 9 ). Also, the influence of objectively measured PA on lipid measures and improved weight loss and weight maintenance in this population have previously been reported ( 10 ). The original Teen-LABS protocol and data and safety monitoring plans were approved by the institutional review board (IRB) at each of the five participating institutions and by the NIH appointed data and safety monitoring board.…”

Section: Materials/subjects/methodsmentioning

confidence: 72%

“…PA has been shown to improve health, promote weight loss, assist with weight loss maintenance, and reduce CVD risk in a dose response manner with increasing benefits as activity increases ( 13 ). Evidence is growing that suggests that PA may provide metabolic and health benefits at lower doses following MBS in adolescents with severe obesity, beyond that attributable to weight/adiposity loss ( 10 ). Our study results provide additional evidence that more PA independently improves insulin sensitivity beyond that provided by MBS alone, which likely predicts a further reduction of the sequelae of insulin resistance and overall CVD risks over time.…”

Section: Discussionmentioning

confidence: 99%

“…Using this model, two categories were identified that we label “less active” (LA) and “more active” (MA), that were linear and quadratic in shape, respectively. The probability of group trajectory membership for each individual was determined from the individual’s trajectory of average step counts across all available time points ( 10 ). The analyses examined insulin sensitivity outcomes and anthropometric outcomes longitudinally from baseline to 6, 12, 24 and 36 months post-MBS.…”

Section: Materials/subjects/methodsmentioning

confidence: 99%

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Physical activity impacts insulin sensitivity post metabolic bariatric surgery in adolescents with severe obesity

et al. 2020

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Background/Objectives: We hypothesized that physical activity (PA) improves insulin sensitivity in adolescents with severe obesity beyond that attributable to metabolic bariatric surgery (MBS). Subjects/Methods: StepWatch™ monitors objectively measured PA in 88 participants in the Teen Longitudinal Assessment of Bariatric Surgery (Teen-LABS) study. Primary outcomes included absolute change in fasting insulin, HOMA-IR, and fasting glucose from pre-surgery (baseline) to 6, 12, 24, and 36 months post-MBS. SAS PROC TRAJ generated activity trajectories based on probability and individual participant step count trajectories. Linear regression models were used, adjusted for baseline value, visit, surgical procedure, sex, and percent change in BMI. Additional models adjusted for percent change in iliac waist circumference (IWC) or percent body fat (BF), measured by bio-impedance. Results: Two activity trajectories were identified: more active (MA, n=13) and less active (LA, n=75). MA baseline mean daily step count was >6 000, increasing to > 9 000 at 2 years. LA mean daily step count remained at approximately 4 000. Few participants recorded moderate step activity (cadence >80 steps/minute). Still, fasting insulin and HOMA-IR differed in association with activity trajectory. MA was associated with a greater absolute decrease in fasting insulin (−7.8μU/ml [95% CI: (−11.8, −3.7)], p =<0.001) and a greater decrease in HOMA- IR (−1.9 [95% CI: (−3.0, −0.7)], p = 0.001), when adjusted for percent change in BMI. The significant independent effect of MA remained when adjusted for percent change in IWC or percent BF. Clinically, 100% of MA trajectory participants normalized fasting insulin, HOMA-IR and fasting glucose by 6 months and normalization remained throughout the 36 month follow up. In contrast, 76.3% and 65.8% of LA trajectory participants normalized fasting insulin and HOMA-IR, respectively, by 12 months with 28.6% of both remaining normalized at 36 months. Conclusion: PA is independently associated with improved insulin sensitivity beyond that attributable to MBS in adolescents with severe obesity.

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Section: Materials/subjects/methodsmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Materials/subjects/methodsmentioning

confidence: 99%

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Physical activity impacts insulin sensitivity post metabolic bariatric surgery in adolescents with severe obesity

et al. 2020

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“…Similar results were found in a study of 108 adolescents with severe obesity, namely from baseline to three years after metabolic bariatric surgery (MBS). Increased activity in adolescents was related to improvements in cardiovascular diseaserelated lipid measures and weight loss after MBS [31]. A recent study analyzed PA and sitting time in 398 BS patients one to 16 years post-surgery and assessed their associations with patient, surgery and weight-loss characteristics.…”

Section: Sociodemographic Data and Pamentioning

confidence: 99%

Excess Weight Loss after Bariatric Surgery: The Influence of Catechol-O-Methyltransferase (COMT) Polymorphism (Val108/158Met), Sociodemographic Variables and Physical Activity

Liebaert¹,

Bliem²,

Unterrainer³

et al. 2020

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Background: In the treatment of morbid obesity bariatric surgery has become the method of choice. Dopamine is the primary modulator of the brain's reward system and plays an essential role in the regulation of food intake. The role of dopamine is well documented in weight regulation and food intake in both animal models and humans. Still, the role of dopamine has not been well studied for weight loss. Catechol-O-methyltransferase (COMT) degrades catecholamines and estrogens are both known to be important risk factors for cardiovascular diseases and consequently obesity. The gene coding for COMT contains a Val108/158Met polymorphism that exerts a considerable influence on enzymatic activity. We hypothesized that this polymorphism might influence weight loss in obese patients, who previously underwent gastric banding surgery. In obesity research, it is known that women tend to lose more weight than men, and weight before surgery might also affect the outcome of weight loss efforts. Several studies have shown that physical activity (PA) plays an important role in maintaining weight as well as in both non-surgical and surgical weight loss. Therefore, we examined whether gender, age, weight before surgery and PA are good predictor variables for the outcome of surgical weight loss. Methods: One to six years after bariatric surgery 74 adults underwent a semi-structured interview. In a second step data on the post-surgical PA level were collected with the Moorehead-Ardelt Quality of Life Questionnaire. Finally, mouth swabs were used for genotyping. Results: 54 women and 20 men were enrolled between January 2004 and September 2009. Short-term EWL in the mid-activity genotype dopamine group (GA)

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“…La mayoría de las pruebas que evalúan específicamente la asociación entre la actividad física y el colesterol no HDL provienen de estudios en pobla-ciones jóvenes. Un estudio que dio seguimiento a 108 adolescentes que tenían cirugía bariátrica por 3 años correlacionó una cantidad mayor de actividad física con mayor disminución absoluta en el no-HDL-C, a pesar de los bajos conteos absolutos de pasos y la lentitud de la cadencia (44) . Un estudio de cohorte que incluyó a 880 escolares noruegos con una edad media de 10,2 años demostró que la sustitución de 30 minutos diarios de sedentarismo por 30 minutos de actividad física moderada a vigorosa (> 2.296 recuentos de acelerómetros/ min) se asoció inversamente con la concentración de colesterol no HDL (45) .…”

Section: Impacto Del Ejercicio Sobre El Colesterol No Hdlunclassified

Impacto del ejercicio sobre el metabolismo de los lípidos y la dislipidemia

Scher-Nemirovsky¹,

Ruiz-Manco²,

Mendivil³

2019

Rev. Nutr. Clin. Metab.

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The chronic practice of exercise induces a series of cellular and organismal adaptations that modify the way the human body metabolizes all macronutrients, including lipids. Endurance exercise and resistance exercise elicit different responses that result in differential effects on lipid and lipoprotein metabolism. These effects are quantitatively and qualitatively different and mediated by distinct signaling pathways. In this review, we summarize relevant evidence on the impact of exercise on lipid and lipoprotein metabolism, and finalize with some practical recommendations on exercise practice for patients with dyslipidemia in the primary care setting.

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Physical Activity Improves Lipid and Weight‐Loss Outcomes After Metabolic Bariatric Surgery in Adolescents with Severe Obesity

Cited by 14 publications

References 32 publications

Physical activity impacts insulin sensitivity post metabolic bariatric surgery in adolescents with severe obesity

Physical activity impacts insulin sensitivity post metabolic bariatric surgery in adolescents with severe obesity

Excess Weight Loss after Bariatric Surgery: The Influence of Catechol-O-Methyltransferase (COMT) Polymorphism (Val108/158Met), Sociodemographic Variables and Physical Activity

Impacto del ejercicio sobre el metabolismo de los lípidos y la dislipidemia

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