Excess Weight Loss after Bariatric Surgery: The Influence of Catechol-O-Methyltransferase (COMT) Polymorphism (Val108/158Met), Sociodemographic Variables and Physical Activity
Abstract:Background: In the treatment of morbid obesity bariatric surgery has become the method of choice. Dopamine is the primary modulator of the brain's reward system and plays an essential role in the regulation of food intake. The role of dopamine is well documented in weight regulation and food intake in both animal models and humans. Still, the role of dopamine has not been well studied for weight loss. Catechol-O-methyltransferase (COMT) degrades catecholamines and estrogens are both known to be important risk … Show more
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