Physical Activity and Alzheimer’s Disease: A Narrative Review

Gronek, Piotr; Balkó, Štefan; Gronek, Joanna; Zając, Adam; Maszczyk, Adam; Celka, Roman; Doberska, Agnieszka; Czarny, Wojciech; Podstawski, Robert; Clark, Cain C. T.; Yu, Fang

doi:10.14336/ad.2019.0226

Cited by 34 publications

(23 citation statements)

References 124 publications

(149 reference statements)

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“…For many years, it has been well-known that regular physical exercise can attenuate the major hallmarks of aging and promote health span by slowing down age-related degenerative processes [ 60 , 61 , 62 ]. Indeed, as we age, the loss of muscle mass and the risks of heart disease and dementia increases, and immune function becomes increasingly impaired [ 63 ].…”

Section: Ampk Signalingmentioning

confidence: 99%

Key Signaling Pathways in Aging and Potential Interventions for Healthy Aging

Zhang

Wang

et al. 2021

Cells

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Aging is a fundamental biological process accompanied by a general decline in tissue function. Indeed, as the lifespan increases, age-related dysfunction, such as cognitive impairment or dementia, will become a growing public health issue. Aging is also a great risk factor for many age-related diseases. Nowadays, people want not only to live longer but also healthier. Therefore, there is a critical need in understanding the underlying cellular and molecular mechanisms regulating aging that will allow us to modify the aging process for healthy aging and alleviate age-related disease. Here, we reviewed the recent breakthroughs in the mechanistic understanding of biological aging, focusing on the adenosine monophosphate-activated kinase (AMPK), Sirtuin 1 (SIRT1) and mammalian target of rapamycin (mTOR) pathways, which are currently considered critical for aging. We also discussed how these proteins and pathways may potentially interact with each other to regulate aging. We further described how the knowledge of these pathways may lead to new interventions for antiaging and against age-related disease.

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Section: Ampk Signalingmentioning

confidence: 99%

Key Signaling Pathways in Aging and Potential Interventions for Healthy Aging

Zhang

Wang

et al. 2021

Cells

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“…Furthermore, the incidence of both dementia and stroke appear to be increasing in tandem worldwide, 6 reflecting socioeconomic status and its influence on largely modifiable vascular risk factors. The “ vascular dysregulation hypothesis ” 7–9 proposes that imbalances between blood flow‐based substrate delivery and brain energy requirements intensify common cardiovascular risks for Alzheimer's disease and related dementias (ADRD) including hypertension, 10–12 cerebrovascular disease 13–15 , and sedentary lifestyle 16,17 . The current thinking is that cerebrovascular dysfunction occurs early in ADRD, 6 and therefore may be an earlier diagnostic marker and a more fruitful therapeutic target.…”

Section: Part I Narrativementioning

confidence: 99%

Plasma hydrogen sulfide: A biomarker of Alzheimer's disease and related dementias

Disbrow

Stokes

Ledbetter

et al. 2021

Alzheimer's & Dementia

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While heart disease remains a common cause of mortality, cerebrovascular disease also increases with age, and has been implicated in Alzheimer's disease and related dementias (ADRD). We have described hydrogen sulfide (H2S), a signaling molecule important in vascular homeostasis, as a biomarker of cardiovascular disease. We hypothesize that plasma H2S and its metabolites also relate to vascular and cognitive dysfunction in ADRD. We used analytical biochemical methods to measure plasma H2S metabolites and MRI to evaluate indicators of microvascular disease in ADRD. Levels of total H2S and specific metabolites were increased in ADRD versus controls. Cognition and microvascular disease indices were correlated with H2S levels. Total plasma sulfide was the strongest indicator of ADRD, and partially drove the relationship between cognitive dysfunction and white matter lesion volume, an indicator of microvascular disease. Our findings show that H2S is dysregulated in dementia, providing a potential biomarker for diagnosis and intervention.

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“…This plastic remodelling seems to be associated with an increase in production of brain-derived neurotrophic factor (BDNF) [5]. The morpho-functional changes translate into improved cognitive performance including learning and memory [6,7], prolong cognitive longevity [8][9][10] and reduce the risk of dementia [8,[11][12][13].…”

Section: Introduction: Lifestyle Neural Plasticity and Cognitive Performancementioning

confidence: 99%

Lifestyle-dependent microglial plasticity: training the brain guardians

Augusto-Oliveira

Verkhratsky

2021

Biol Direct

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Lifestyle is one of the most powerful instruments shaping mankind; the lifestyle includes many aspects of interactions with the environment, from nourishment and education to physical activity and quality of sleep. All these factors taken in complex affect neuroplasticity and define brain performance and cognitive longevity. In particular, physical exercise, exposure to enriched environment and dieting act through complex modifications of microglial cells, which change their phenotype and modulate their functional activity thus translating lifestyle events into remodelling of brain homoeostasis and reshaping neural networks ultimately enhancing neuroprotection and cognitive longevity.

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Physical Activity and Alzheimer’s Disease: A Narrative Review

Cited by 34 publications

References 124 publications

Key Signaling Pathways in Aging and Potential Interventions for Healthy Aging

Key Signaling Pathways in Aging and Potential Interventions for Healthy Aging

Plasma hydrogen sulfide: A biomarker of Alzheimer's disease and related dementias

Lifestyle-dependent microglial plasticity: training the brain guardians

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