2021
DOI: 10.3390/cells10030660
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Abstract: Aging is a fundamental biological process accompanied by a general decline in tissue function. Indeed, as the lifespan increases, age-related dysfunction, such as cognitive impairment or dementia, will become a growing public health issue. Aging is also a great risk factor for many age-related diseases. Nowadays, people want not only to live longer but also healthier. Therefore, there is a critical need in understanding the underlying cellular and molecular mechanisms regulating aging that will allow us to mod… Show more

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Cited by 58 publications
(31 citation statements)
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“…AMPK activation plays an important role in cellular senescence and aging [ 45 ]. The AMPK pathway is downregulated in oxidative stress-induced senescence, whereas pharmacological activation of AMPK or swimming exercise training may increase AMPK and inhibit senescence-associated pathways [ 13 , 46 ].…”
Section: Discussionmentioning
confidence: 99%
“…AMPK activation plays an important role in cellular senescence and aging [ 45 ]. The AMPK pathway is downregulated in oxidative stress-induced senescence, whereas pharmacological activation of AMPK or swimming exercise training may increase AMPK and inhibit senescence-associated pathways [ 13 , 46 ].…”
Section: Discussionmentioning
confidence: 99%
“…The SCN controls melatonin and cortisol release, the temperature of the body, and can respond to oxidative stress [94,107,108]. The basic helix-loop-helix -PAS (Period-Arnt-Single-minded) transcription factor family oversee Cryptochrome (Cry1 and Cry2) and Period (Per1, Per2, and Per3) genes [8, 80,86,92,[109][110][111]. CLOCK and BMAL1 [90] are part of the family for clock genes with PER:CRY heterodimers able to block transcription controlled by CLOCK:BMAL1 complexes.…”
Section: Circadian Clock Genes Neurodegeneration and Cognitive Lossmentioning
confidence: 99%
“…mTOR is the primary component of the protein complexes mTOR Complex 1 (mTORC1) and mTOR Complex 2 (mTORC2) [158][159][160]. mTORC1 and mTORC2 are divided into subcomponents [111,140,[161][162][163]. mTORC1 has a number of components.…”
Section: Circadian Clock Genes and The Mechanistic Target Of Rapamycinmentioning
confidence: 99%
“…The SCN controls the temperature of the body, cortisol and melatonin release, and oxidative stress responses through a connected system among the hy-pothalamic nuclei, pineal gland, and vasoactive intestinal peptide [88,102,103]. As part of the biological clock gene group, members of the basic helix-loop-helix-PAS (Period-Arnt-Single-minded) transcription factor family, that include CLOCK and BMAL1 [104], control gene expression of Cryptochrome (Cry1 and Cry2) and Period (Per1, Per2, and Per3) [6,78,84,86,[105][106][107]. Modulation of these pathways and auto-feedback interactions are controlled by PER:CRY heterodimers that block transcription during nuclear translocation promoted by CLOCK:BMAL1 complexes.…”
Section: Biological Clocks and Circadian Rhythm Pathways For Dementia Treatmentmentioning
confidence: 99%