Physalis angulata extract exerts anti-inflammatory effects in rats by inhibiting different pathways

Bastos, Gilmara N. T.; Silveira, A.J.A.; Salgado, Cláudio Guedes; Picanço-Diniz, Domingos Luiz Wanderley; Nascimento, José Luíz Martins do

doi:10.1016/j.jep.2008.04.005

Cited by 81 publications

(64 citation statements)

References 24 publications

(34 reference statements)

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“…Ekstrak metanol biji Piper cubeba, bunga P. angulata L. dan bunga Rosa hybrida signifikan menghambat udem kaki pada tikus yang diindukasi karagenan masing-masing 70; 68 dan 50 % (Choi & Hwang, 2003). Selain itu, penelitian mengenai aktivitas antiinflamasi secara in-vitro pada ekstrak air akar P. angulata L. dengan dosis 1 dan 5 mg/kgBB terbukti memiliki aktivitas antiinflamasi dengan cara menghambat pelepasan mediator terjadinya inflamasi antara lain adenosine deaminase (ADA), prostaglandin (PG), dan nitrit oksida (NO) (Bastos et al, 2008). Senyawa-senyawa steroid seperti fisalin B, F dan G yang diisolasi dari P.angulata L. dapat menurunkan kadar NO dan inferon γ (Soares et al, 2003).…”

Section: Traditional Medicine Journal 22(3) 2017unclassified

Antiinflammatory Activity Test of Aqueous Extracts Herb of Ciplukan (Physalis angulata L.) in Caragenan Inducted Wistar Rat (Rattus norvegicus L.)

2017

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Section: Traditional Medicine Journal 22(3) 2017unclassified

Antiinflammatory Activity Test of Aqueous Extracts Herb of Ciplukan (Physalis angulata L.) in Caragenan Inducted Wistar Rat (Rattus norvegicus L.)

2017

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“…Although there is extensive knowledge on physiological and molecular mechanisms that regulate salt tolerance in Arabidopsis thaliana (L.) Heynh (Peng et al 2009, Tian et al 2011, much less is known for wild species, such as Physalis angulata (Solanaceae). Physalis angulata is widely used in ethnomedicine due to the presence of secsteroid (physalins) that are produced in stems and leaves (Bastos et al 2008). The anti-infl ammatory and immunomodulatory effects of the physalins B, D, F and G, have been well documented (Vieira et al 2005, Magalhães et al 2006, Soares et al 2006, Damu et al 2007, Guimarães et al 2009, Yu et al 2010.…”

Section: Introductionmentioning

confidence: 99%

Effect of osmopriming on germination and initial growth of Physalis angulata L. under salt stress and on expression of associated genes

Souza

Pelacani

Willems

et al. 2016

An. Acad. Bras. Ciênc.

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This study aimed to evaluate the effects of priming on seed germination under salt stress and gene expression in seeds and seedlings of P. angulata L. After priming for 10 days, seed germination was tested in plastic trays containing 15 ml of water (0 dS m -1 -control) or 15 ml of NaCl solution (2, 4, 6, 8, 10, 12, 14 and 16 dS m -1). Fresh and dry weight of shoots and roots of seedlings were evaluated at 0, 2, 4, 6, 8 dS m -1 . Total RNA was extracted from whole seeds and seedlings followed by RT-qPCR. The target genes selected for this study were: ascorbate peroxidase (APX), glutathione-S-transferase (GST), thioredoxin (TXN), high affi nity potassium transporter protein 1 (HAK1) and salt overly sensitive 1 (SOS1). At an electroconductivity of 14 dS m -1 the primed seeds still germinated to 72%, in contrast with the non-primed seeds which did not germinate. The relative expression of APX was higher in primed seeds and this may have contributed to the maintenance of high germination in primed seeds at high salt concentrations. GST and TXN displayed increased transcript levels in shoots and roots of seedlings from primed seeds. Priming improved seed germination as well as salt tolerance and this is correlated with increased expression of APX in seeds and SOS1, GST and TXN in seedlings.

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“…The air pouch were carried out as described by Bastos et al 11 . The sterile air was obtained by capturing in a laminar flow hood to prevent contamination.…”

Section: Air Pouch Preparation and Induction Of The Inflammatory Processmentioning

confidence: 99%

“…In the study of the anti-inflammatory activity in vivo use of subcutaneous air pouch as the experimental model has been described in several works 11 . This model is used to perform a quantitative analysis of the factors involved in the inflammatory process through the formation of a symmetrical elliptical space, created by injecting air into the subcutaneous tissue of rats 30 .…”

Section: Pharmaceutical Biotechnologymentioning

confidence: 99%

Study of anti-inflammatory and analgesic properties of 3-benzoyl-propionic acid

Ávila¹,

Sena²,

Machi³

et al. 2017

PRMJ

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Summary Inflammation is an attempt by the body to remove noxious stimuli and initiate thus a cascade of responses in order to promote healing. There are a variety of inflammatory mechanisms involved in infections, chronic diseases and other tissue damage. Understanding these mechanisms and the search for new anti-inflammatory drugs with greater specificity and fewer side effects, underlying the development and improvement of new protocols and standardization of experimental inflammatory models to understand better these issues. The aim of this study was to evaluate the anti-inflammatory and analgesic activity of 3-benzoyl-propionic acid (3BPA) and its potential toxicological effect. To test the 3BPA as new anti-inflammatory and analgesic drug, the use carrageenan air pouch model 1% by in vitro model of cell culture to test genocytotoxicity. In the in vitro model the 3BPA presented low level of genotoxic and low cytotoxicity risk, shown by comet assay and no damage to the plasma membrane by hemolytic test erythrocytes. In the study of anti-inflammatory activity in vivo by the air pouch method were conducted nitrite dose trials, PGE 2 levels and cell migration. To verify analgesic effects of 3BPA drug in vivo tests of abdominal contortions induced by acetic acid and formalin were performed. Regard to the anti-inflammatory activity, 3BPA showed intense activity shown in marked reduction of cell migration and levels of NO, with large populations of neutrophils and reduction of PGE 2 values at a dose of 0.5mg/kg. In studies of antinociceptive activity, 3BPA reduced the number of writhes and the time lick the neurogenic and inflammatory phases of the formalin test. The results of this study also advanced substantially with respect to anti-inflammatory and analgesic properties of 3BPA by providing evidence of their likely mechanism of action, through the evaluation of antinociceptive activity, as well as the anti-inflammatory activity in vitro and in vivo, where the 3BPA showed no genotoxic effect.

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Physalis angulata extract exerts anti-inflammatory effects in rats by inhibiting different pathways

Cited by 81 publications

References 24 publications

Antiinflammatory Activity Test of Aqueous Extracts Herb of Ciplukan (Physalis angulata L.) in Caragenan Inducted Wistar Rat (Rattus norvegicus L.)

Antiinflammatory Activity Test of Aqueous Extracts Herb of Ciplukan (Physalis angulata L.) in Caragenan Inducted Wistar Rat (Rattus norvegicus L.)

Effect of osmopriming on germination and initial growth of Physalis angulata L. under salt stress and on expression of associated genes

Study of anti-inflammatory and analgesic properties of 3-benzoyl-propionic acid

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