Phylogenetically conserved antigen on nerve cells and lymphocytes resembles myelin-associated glycoprotein.

Péault, Bruno; Chen, C.-L. H.; Cooper, Max D.; Barbu, M.; Lipinski, Marc; Douarin, Nicole M. Le

doi:10.1073/pnas.84.3.814

Cited by 20 publications

(16 citation statements)

References 24 publications

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“…The reactivity of splenic EARC with HNK-1 is in sharp contrast with the findings of PØault et al (1987) who detected, in addition to nerve cells, only a few CD57 + cells in sections of chicken spleen. This difference is probably attributable to the different preparative treatments of these tissue sections for immunohistochemistry.…”

Section: Discussioncontrasting

confidence: 74%

“…1A±D, arrows), as previously demonstrated by PØault et al (1987). However, HNK-1 also strongly reacted with the fibroblastic reticular cells surrounding penicillary capillaries and forming the splenic ellipsoids or Schweigger-Seidel sheaths (Fig.…”

Section: Immunohistochemistrysupporting

confidence: 68%

“…This approach is more aggressive for glycolipids than the acetone fixation that we have applied. Therefore, CD57 was probably lost or unavailable to the MAb in the study of PØault et al (1987). The sensitivity of the CD57 + molecules of the EARC implies that they are different from the CD57 + glycoproteins on lymphocytes of the bursa of the chicken; these glycoproteins appear to be identical to the myelinassociated glycoprotein on nerve cells (PØault et al 1987).…”

Section: Discussionmentioning

confidence: 97%

“…One of these is HNK-1, which cross-reacts with the chicken CD57 (PØault et al 1987;Ratcliffe et al 1993). Originally, the MAb HNK-1, raised against a human thymoma-cell line, was shown to identify human granular leucocytes with natural killer and antibody-dependent killer capabilities (Abo and Balch 1981).…”

Section: Introductionmentioning

confidence: 97%

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CD57, a marker for B-cell activation and splenic ellipsoid-associated reticular cells of the chicken

Mast

Goddeeris

1997

Cell and Tissue Research

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We have demonstrated that the ellipsoid-associated reticular cells of chicken spleen express CD57, a marker for B-cell activation. These cells are characterised by their spindle-shaped morphology, tissue distribution and the absence of certain leucocyte-specific markers. They are phagocytotic and possess high endogenous non-specific esterase activity. Previous reports failed to detect CD57 expression on ellipsoid-associated reticular cells, probably because the tissue sections were differently treated before immunohistochemistry. CD57 is also expressed by a small number of T-cells in the spleen and the caecal tonsils. This number is highly variable between individual chickens depending on the activation state of the immune system. Moreover, CD57 is expressed by bursal lymphocytes (90% or more) but not by B-cells of the peripheral blood. More interestingly, we have been able to discriminate and quantify three B-cell populations of the secondary lymphoid organs, i.e. resting B-cells, germinal centre B-cells and plasma cells, based on their expression levels of CD57 and Bu-1 (a pan B-cell marker). Thus, CD57 should be considered as a B-cell activation marker, rather than as a marker for bursal B-cells; it is also a valuable marker for the immunohistochemical study of ellipsoid-associated reticular cells of chicken spleen.

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Section: Discussioncontrasting

confidence: 74%

Section: Immunohistochemistrysupporting

confidence: 68%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 97%

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CD57, a marker for B-cell activation and splenic ellipsoid-associated reticular cells of the chicken

Mast

Goddeeris

1997

Cell and Tissue Research

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“…DM1 and DM2 (anti-DM-GRASP) (14) were provided by S. Chang (University of Pennsylvania). Anti-HNK-1 was obtained from the American Type Culture Collection (58).…”

Section: Methodsmentioning

confidence: 99%

v-rel Induces Ectopic Expression of an Adhesion Molecule, DM-GRASP, during B-Lymphoma Development

Zhang

Slaughter

Humphries

1995

Molecular and Cellular Biology

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In an effort to identify aberrantly expressed genes in v-rel-induced tumors, monoclonal antibodies were developed that reacted selectively with avian B-cell tumors. One antibody, HY78, immunoprecipitated a 120-kDa glycoprotein (p120) from cells that express v-rel. N-terminal amino acid sequencing of p120 identified a 27-amino-acid sequence that is also present in DM-GRASP, an adhesion molecule belonging to the immunoglobulin superfamily. Evidence from tissue distribution, immunological cross-reaction, PCR amplification, cDNA cloning, and DNA sequence shows that p120 is indeed DM-GRASP. Northern (RNA) analysis using a probe from the DM-GRASP gene identified a

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Cross‐linking of the surface immunoglobulin on lymphocytes from the bursa of Fabricius results in second messenger generation

Ratcliffe

Tkalec

1990

Eur J Immunol

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Much remains to be clarified the functional capacities of the two major reciprocal subsets of human CD4+ cells which we interpret to be naive and memory cells. CD4+ naive (CD45RA+, LFA-3-) and memory (CD45R0+, LFA-3+) cells were rigorously purified by immunomagnetic negative selection. Their proliferation was measured in response to four protocols of receptor-mediated activation: soluble anti-CD3 mAb, plastic-immobilized anti-CD3 mAb, activating pairs of anti-CD2 mAb, and "superantigens" staphyloccocal enterotoxins A and B (SEA and SEB). Naive cells proliferated much less than memory cells to each of these four regimens although their capacity to respond was demonstrated by strong PHA-induced proliferation. Although three of the regimens depend on autologous monocytes, poorer naive cell responses are also observed to anti-CD3 mAb immobilized on plastic in the absence of monocytes; this implies an intrinsic hyporesponsiveness of naive cells, independent of their potentially weaker interaction with monocytes. Naive cells proliferated less than memory cells to superantigens SEA and SEB over a wide dose range; this assumes particular importance because such superantigens are believed to more closely mimic antigen-specific stimulation than anti-CD3 mAb. The possibility was explored that hyporesponsiveness of naive cells reflects the fact that naive cells require additional co-stimuli to facilitate their activation. In support of this concept, we observed that proliferation of naive cells to anti-CD3 mAb and SEA or SEB (but not to anti-CD2 mAb pairs) was consistently enhanced by pre-activation of monocytes present in the culture. Naive cell proliferative responses were augmented further in cultures supplemented with interleukin (IL) 1 beta and IL 6 or exposed to the co-stimulating mAb anti-CD28 and anti-CD44. The pattern of augmentation was dependent on the specific triggering regimen: anti-CD44 mAb was particularly effective in augmenting the response to superantigens, anti-CD28 mAb for the anti-CD3 response and IL 1 beta/IL 6 for that induced by anti-CD2 mAb pairs. With particular combinations of stimulus/co-stimuli naive cell proliferation was as strong as that of memory cells. We interpret these findings to indicate that naive cells are capable of responding to antigen, but that such responses are critically dependent on the available co-stimuli in vivo.

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Phylogenetically conserved antigen on nerve cells and lymphocytes resembles myelin-associated glycoprotein.

Cited by 20 publications

References 24 publications

CD57, a marker for B-cell activation and splenic ellipsoid-associated reticular cells of the chicken

CD57, a marker for B-cell activation and splenic ellipsoid-associated reticular cells of the chicken

v-rel Induces Ectopic Expression of an Adhesion Molecule, DM-GRASP, during B-Lymphoma Development

Cross‐linking of the surface immunoglobulin on lymphocytes from the bursa of Fabricius results in second messenger generation

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