CD57, a marker for B-cell activation and splenic ellipsoid-associated reticular cells of the chicken

Mast, Jan; Goddeeris, Bruno

doi:10.1007/s004410050984

Cited by 21 publications

(12 citation statements)

References 39 publications

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“…Supporting cells sometimes showed phagocytic and migratory activity (Olah et al, 1985). In addition, supporting cells were blood-borne cells and play an important role in the production of extracellular matrix (Jeurissen, 1993; Mast & Goddeeris, 1997; Nagy et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Architecture and Cellular Composition of the Spleen in the Japanese Quail (Coturnix japonica)

Mustafa

El‐Desoky

2020

Microsc Microanal

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The spleen is considered a key player in birds’ immunity. The stroma and the parenchyma of the spleen of the adult quail were demonstrated histologically, histochemically, and ultrastructurally. A thin capsule and the absence of trabeculae were the most characteristics of spleen stroma. The demarcation between white pulp and red pulp was not observed in the quail. White pulp formed from the periarterial lymphatic sheath and the periellipsoidal lymphatic sheath, both of which were surrounded by arteriole and ellipsoid, respectively. Ellipsoids appeared more numerous and were characterized by cuboidal lining of the epithelium and supporting cells. Red pulp consisted of sinuses and cords. White pulp and red pulp of the quail spleen contained various cells, such as red blood cells, macrophages, heterophils with characteristic granules, lymphocytes of different sizes, dendritic cells, plasma cells, and telocytes. In addition, closed circulation and open circulation established the blood flow on the spleen.

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Section: Discussionmentioning

confidence: 99%

Architecture and Cellular Composition of the Spleen in the Japanese Quail (Coturnix japonica)

Mustafa

El‐Desoky

2020

Microsc Microanal

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“…Both cell types express CD45 hemopoietic antigens suggesting they are of blood‐born origin. The ellipsoid‐associated macrophages also express 74.2 and KULO1 monocyte‐macrophage–specific antigens (Jeurissen et al, 1992; Jeurissen, 1993; Mast and Goddeeris, 1998). After phagocytosis, the macrophages detach from the surface of the sheath and migrate through the periellipsoidal white pulp to the PALS (Oláh and Glick, 1982; Gallego et al, 1993).…”

Section: Discussionmentioning

confidence: 99%

Peripheral blood fibrocytes contribute to the formation of the avian spleen

Nagy

Bíró

Takács

et al. 2004

Developmental Dynamics

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Chick-quail chimeric studies were made to determine the origin of the cells of splenic ellipsoid. The ellipsoid is formed by supporting and phagocytic cells, which are embedded in a well-organized extracellular matrix. Splenic and bursal anlage of 6-to 6.5-day-old quail embryos were transplanted into the coelomic cavity of 3-day-old chick embryos and further incubated for 17 days. CD45؉ chicken hemopoietic cells colonized both organs. They formed the cells of the ellipsoid and the periellipsoidal white pulp of the transplanted quail spleen. Chicken-specific collagen III was produced only in the donor quail spleen, but not in the bursa of Fabricius. The CD45؉/collagen I؉/collagen III؉ cells are probably identical with the mammalian peripheral blood fibrocytes and contribute to the formation of supporting cells, whereas the CD45؉/74.2؉ ellipsoid-associated macrophages are of monocytic origin. We provide, for the first time, experimental evidence that peripheral blood fibrocytes exist in the avian species; they are present in the circulation of the chicken embryo and contribute to the organogenesis of the spleen. Developmental Dynamics 232:55-66, 2005.

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“…This proliferative defect had been shown in all lymphocyte subsets, which express CD57 (CD4 ϩ and CD8 ϩ T lymphocytes and NK cells) and with some relevant exception [25], was not overcome by addition of IL-2 or IL-15. Despite neural crest and T-lineage restriction, in chickens, CD57 is considered as a B cell activation marker for bursal lymphocytes [26].…”

Section: Introductionmentioning

confidence: 99%