Phyllodes Tumor of the Breast: A Clinicopathological Evaluation of 55 Cases

Abstract

European Journal of Breast Health (Eur J Breast Health) is an international, scientific, open access periodical published by independent, unbiased, and double-blinded peer-review principles. It is the official publication of the Turkish Federation of Breast Diseases Societies, and Senologic International Society is the official supporter of the journal.

A Case of Phyllodes Tumor of the Breast with Mixed Liposarcoma: Case Report and Literature Review

“…17 In a study by Kim et al 18 the average tumor diameter was found to be 4 cm; those of benign, borderline, and malignant PTs were 3.7, 4.2, and 6.2 cm, respectively. Another study 19 showed that the average diameters of benign, borderline, and malignant PTs were 3.2, 5.06, and 4.6 cm, respectively. According to a literature review, the general diameter of malignant lobar tumors is greater than 3 cm.…”

Invasive ductal carcinoma arising in borderline phyllode tumor: A potential role of PIK3CA mutation

“…Invasive carcinomatous lesions associated with phyllodes tumors of the breast are exceedingly rare, with fewer than 20 cases described in the last 50 years [4] , [10] . The majority of histological types being ductal invasive carcinomas/NST, invasive lobular carcinomas or squamous cell carcinomas [4] , [10] , [11] .…”

“…Invasive carcinomatous lesions associated with phyllodes tumors of the breast are exceedingly rare, with fewer than 20 cases described in the last 50 years [4] , [10] . The majority of histological types being ductal invasive carcinomas/NST, invasive lobular carcinomas or squamous cell carcinomas [4] , [10] , [11] . These carcinomas are most often associated with benign phyllode tumors (60–80% of cases) but much more rarely with borderline or malignant ones [11] , [12] , [13] , [14] .…”

“…These carcinomas are most often associated with benign phyllode tumors (60–80% of cases) but much more rarely with borderline or malignant ones [11] , [12] , [13] , [14] . The molecular biological mechanisms associated with the development of these carcinomatous lesions in phyllode tumors remain poorly understood [4] , [5] , [10] , [13] . For the first time in this work, we were able to demonstrate the presence of mutations in the phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) gene.…”

Vulvar phyllodes tumor presenting as an epidermoid cyst

“…Phyllodes tumors are rare fibroepithelial tumors most often arising in the breast where, they comprise 1% of neoplasms 1 . Mueller described these tumors in 1838 as slow‐growing masses termed “cystosarcoma phyllodes.” 2 The current WHO terminology “phyllodes tumor” comprises mixed epithelial‐stromal cystic tumors with epithelial leaf‐like structures and stromal hyperplasia 3 …”