Invasive ductal carcinoma arising in borderline phyllode tumor: A potential role of PIK3CA mutation

Bouri, Sarah; Simon, Philippe; D’Haene, Nicky; Catteau, Xavier; Noël, Jean‐Christophe

doi:10.1016/j.ijscr.2020.10.134

Cited by 3 publications

(1 citation statement)

References 18 publications

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“…In a case of invasive carcinoma NST within a borderline PT, mutations in the PIK3CA gene were present in both the epithelial and stromal components. Such mutations are present in 49% of luminal A tumours and also implicated in malignant progression of PTs [73]. Furthermore, Dietrich elucidated clonal abnormalities in both the epithelium and stroma of PTs, while Kuijper also demonstrated monoclonality in PT epithelium.…”

Section: Discussionmentioning

confidence: 99%

Epithelial Carcinomas Arising within Phyllodes Tumours of the Breast: A Review of Their Pathological Characteristics

Cook,

Lee,

Tan

2023

Pathobiology

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Epithelial proliferation is a common feature of phyllodes tumours (PT) but epithelial malignancy is rare. This review seeks to further our understanding of epithelial malignancy within phyllodes tumours by analysing their histopathological and molecular characteristics in previously reported cases in the literature. PubMed was searched for case reports, case series and literature reviews of in situ and invasive carcinoma within phyllodes tumours. Only cases where the carcinoma was within the PT were included. Cases of synchronous carcinoma in the ipsilateral or contralateral breast were excluded. Eighty-six cases of in situ or invasive carcinoma within a PT were identified. Across the grades of phyllodes tumours there was a similar proportion of invasive carcinomas compared to in situ lesions. The malignant stroma correlates with a higher likelihood of epithelial malignancy, and molecular studies support a possible causal pathophysiological relationship. Malignant phyllodes tumours as compared to benign appear to have a greater likelihood to contain either an in-situ or invasive epithelial malignancy. This higher likelihood suggests that interactions between the malignant stroma and the transforming epithelium may play a significant role in the phenomenon which remains to be elucidated.

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Section: Discussionmentioning

confidence: 99%

Epithelial Carcinomas Arising within Phyllodes Tumours of the Breast: A Review of Their Pathological Characteristics

Cook,

Lee,

Tan

2023

Pathobiology

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A Case of Phyllodes Tumor Combined with Lobular Carcinoma of the Breast with Microinvasion

Imanishi

Noda

Takashima³

et al. 2022

Nihon Rinsho Geka Gakkai Zasshi (J Jpn Surg Assoc)

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Ductal Carcinoma in Situ Arising in a Boarderline Malignant Phyllodes Tumor—A Case Report—

KAJI,

KUROSE,

OKUBO

et al. 2023

Nihon Rinsho Geka Gakkai Zasshi (J Jpn Surg Assoc)

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Invasive ductal carcinoma arising in borderline phyllode tumor: A potential role of PIK3CA mutation

Abstract: Highlights Invasive carcinomatous lesions associated with borderline phyllodes tumors are extremely rare. Molecular biological mechanisms associated with this kind of lesions are unknown. PIK3CA gene mutation could be implicated in the development of these lesions.

Cited by 3 publications

References 18 publications

Epithelial Carcinomas Arising within Phyllodes Tumours of the Breast: A Review of Their Pathological Characteristics

Epithelial Carcinomas Arising within Phyllodes Tumours of the Breast: A Review of Their Pathological Characteristics

A Case of Phyllodes Tumor Combined with Lobular Carcinoma of the Breast with Microinvasion

Ductal Carcinoma in Situ Arising in a Boarderline Malignant Phyllodes Tumor—A Case Report—

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