A Case of Phyllodes Tumor of the Breast with Mixed Liposarcoma: Case Report and Literature Review

Shi, Minmin; Wang, Ning; Yao, Qing; Dong, Shuangshuang; Feng, Xiaoyuan; Jin, Zhao; Zou, Hong; Pang, Lijuan; Yan, Qi

doi:10.2147/ott.s298379

Cited by 5 publications

(3 citation statements)

References 47 publications

(38 reference statements)

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“…A key distinction between MPT with sarcomatous differentiation and primary sarcoma is the absence of an epithelial component in the latter. In order to provide a comprehensive understanding, we have conducted a review of the clinical characteristics of PT with heterogeneous elements, which are presented in Table 1 (12)(13)(14)(15)(16)(17)(18)(19). In our reported case, the predominant recurrence element is rhabdomyosarcoma, while the presence of epithelium in MPT is scarcely observed.…”

Section: Discussionmentioning

confidence: 99%

Case Report: A 13-year-old adolescent diagnosed as malignant phyllodes tumor combined with rhabdomyosarcoma differentiation

Lian,

Gao,

Yao

et al. 2023

Front. Oncol.

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Phyllodes tumor (PT) is an infrequent type of breast neoplasm, constituting a mere 0.5%–1.5% of the entirety of breast tumors. The malignant phyllodes tumor (MPT) comprises only 15% of all phyllodes tumors, and its transformation into rhabdomyosarcoma (RMS) is exceedingly rare in clinical practice. Given its insensitivity to chemotherapy and radiotherapy, treatment options for MPT patients are limited, leaving complete surgical resection as the only option. Therefore, it is imperative to investigate the effective utilization of the heterogeneous differentiation characteristics of MPT to expand treatment alternatives for these patients. In this case report, we represent a 13-year-old adolescent diagnosed with giant breast MPT with RMS differentiation and pulmonary metastasis. The initial step in the treatment process involved radical surgical resection, followed by the administration of four cycles of VDC/IC chemotherapy, which is widely recognized as the standard chemotherapy for RMS. Regrettably, the delay in initiating chemotherapy resulted in minimal observable changes in the size of the pulmonary metastatic nodule. Additionally, a comprehensive literature review on the characterization of MPT with heterogeneous differentiation was conducted to enhance comprehension of the diagnosis and treatment of this uncommon disease in clinical practice. Meanwhile, this case also reminds the doctors that when we diagnose a patient as MPT, it is crucial to consider its heterogenous nature and promptly initiate adjuvant treatment. By targeting the differentiation element of MPT, it becomes feasible to overcome the previously perceived limitation of surgical intervention as the sole treatment option.

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Section: Discussionmentioning

confidence: 99%

Case Report: A 13-year-old adolescent diagnosed as malignant phyllodes tumor combined with rhabdomyosarcoma differentiation

Lian,

Gao,

Yao

et al. 2023

Front. Oncol.

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“…It is worth noting that cases of primary liposarcoma of the breast, which is a relatively rare condition, are not often documented in imaging results. Imaging methods have limitations in regard to providing accurate diagnoses, and as a result, the final diagnosis often relies on surgical resection and subsequent pathological examination [11].…”

Section: Discussionmentioning

confidence: 99%

Initial Imaging Findings of Breast Liposarcoma: A Case Report

Alduraibi

2023

Diagnostics

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Liposarcoma of the breast is a rare form of cancerous tumor that can be mistaken for primary breast cancer. A recent instance involved a woman who was 54 years old and went in for her annual screening mammogram. The mammogram revealed that she had a 1 cm focal asymmetry of equal density in her right axillary tail, approximately 9 cm from the nipple. After nine months, the patient observed a rapidly growing mass even though the initial ultrasound scan did not detect anything unusual. A targeted mammogram demonstrated a large and dense mass confined to the right axillary tail, followed by an ultrasound scan that revealed a heterogeneous hyperechoic, echogenic mass. Histopathology after surgery showed that the patient had an undifferentiated pleomorphic breast liposarcoma. This diagnosis was reached after the patient underwent surgery.Liposarcoma of the breast is a concerning condition that needs careful management and close monitoring, although it is relatively uncommon. Early detection of the patient’s condition and prompt treatment can help improve the patient’s prognosis. This can be accomplished by remaining vigilant with routine screenings and following up on any unusual findings or changes in breast tissue. However, it is possible to diagnose this condition as primary breast cancer incorrectly; consequently, healthcare providers need to conduct comprehensive evaluations to ensure diagnostic accuracy and the delivery of appropriate treatment.

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“…4 Recent data suggest that malignant PT cells exhibit mesenchymal stem cell characteristics and can be induced or spontaneously differentiated into other lineages, consistent with previous reports on the heterogenic differentiation of PT. 6 The differential diagnosis includes tumors of the breast showing bone and cartilaginous differentiation which include Intraductal papilloma with stromal metaplasia, cystosarcoma phyllodes, stromal sarcoma, and adenocarcinoma with metaplasia. 7 Surgical treatment is generally the treatment of choice for phyllodes tumors, regardless of its histological subtype.…”

Section: Discussionmentioning

confidence: 99%

Malignant phyllodes tumor with heterologous sarcomatous element: A rare case report

Asotra,

Sharma,

Asotra

et al. 2023

IJPO

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Phyllodes tumors being a rare neoplasm of the breast attributes only 0.3% to 1% of all breast tumors, with an annual incidence of about 2 per million women. Malignant differentiation of phyllodes tumors can occur, resulting in cases of extremely rare heterologous sarcomatous differentiation. We present a rare case of a 63-year-old women with features of malignant phyllodes with sarcomatous (chondrosarcomatous) differentiation.Morphologically, phyllodes tumors are categorized as benign, borderline and malignant based on the scope of stromal atypia, mitotic activity, stromal overgrowth, and the tumor margins. The presence of heterologous elements in a phyllodes directly upgrades it to a malignant category. A close follow-up with a CT scan is of utmost need to detect the recurrence and metastasis to the earliest.

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A Case of Phyllodes Tumor of the Breast with Mixed Liposarcoma: Case Report and Literature Review

Cited by 5 publications

References 47 publications

Case Report: A 13-year-old adolescent diagnosed as malignant phyllodes tumor combined with rhabdomyosarcoma differentiation

Case Report: A 13-year-old adolescent diagnosed as malignant phyllodes tumor combined with rhabdomyosarcoma differentiation

Initial Imaging Findings of Breast Liposarcoma: A Case Report

Malignant phyllodes tumor with heterologous sarcomatous element: A rare case report

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