Photothermal tumor ablation in mice with repeated therapy sessions using NIR-absorbing micellar hydrogels formed in situ

Hsiao, Chun Wen; Chuang, Er Yuan; Chen, Hsin Lung; Wan, Dehui; Korupalli, Chiranjeevi; Liao, Zi-Xian; Chiu, Ya Ling; Chia, Wei-Tso; Lin, Kun; Sung, Hsing‐Wen

doi:10.1016/j.biomaterials.2015.03.060

Cited by 95 publications

(75 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Compared with the widely used inorganic gold, carbon based NIR photothermal agents (PTA), and organic dyes, the polymeric PTA, such as polyaniline (PAN) exhibited strong absorption coefficients and excellent photostability . While the poor water solubility of PAN results in the need for using poloxamer or chitosan, and few of works focus on the tunable morphology and size, which is crucial to dispersibility and cellular uptake . It is desirable to develop a universal approach for synthesis of PTA with expected sizes.…”

Section: Methodsmentioning

confidence: 99%

Nanoscale Polymer Metal–Organic Framework Hybrids for Effective Photothermal Therapy of Colon Cancers

et al. 2016

View full text Add to dashboard Cite

A UiO-66 core with various sizes acts as heterogeneous nucleation center and enables aniline polymerization under ambient conditions. The as-synthesized UiO-66@PAN possesses uniform size and excellent dispersibility in aqueous solution. UiO-66@PAN can be internalized by cancer cells via endocytosis, and indicates significant photothermal therapeutic effect in vitro, and can effectively inhibit the growth of colon cancers in vivo.

show abstract

Section: Methodsmentioning

confidence: 99%

Nanoscale Polymer Metal–Organic Framework Hybrids for Effective Photothermal Therapy of Colon Cancers

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Until very recently, several studies have reported that PANI nanoparticles can convert NIR light to thermo A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT 4 energy. Thus, they can act as potential photothermal agents [21][22][23]. However, PANI nanoparticles alone have limited applications in cancer diagnosis and therapy due to low target to background contrast and poor tumor uptake [22,24].…”

Section: Introductionmentioning

confidence: 99%

Rapamycin/DiR loaded lipid-polyaniline nanoparticles for dual-modal imaging guided enhanced photothermal and antiangiogenic combination therapy

Wang

Guo

et al. 2016

Journal of Controlled Release

View full text Add to dashboard Cite

Imaging-guided photothermal therapy (PTT) has promising application for treating tumors. Nevertheless, so far imaging-guided photothermal drug-delivery systems have been developed with limited success for tumor chemo-photothermal therapy. In this study, as the proof-of-concept, a stimuli-responsive tumor-targeting rapamycin/DiR loaded lipid-polyaniline nanoparticle (RDLPNP) for dual-modal imaging-guided enhanced PTT efficacy is reported for the first time. In this system, polyaniline (PANI) with π-π electronic conjugated system and effective photothermal efficiency is chosen as the appropriate model receptor of fluorescence resonance energy transfer (FRET), and loaded cyanine probe (e.g., 1,1-dioctadecyl-3,3,3,3-tetramethylindotricarbocyanine iodide, DiR) acts as the donor of near-infrared fluorescence (NIRF). In addition, rapamycin (RAPA), which is used as the antiangiogenesis chemotherapeutic drug, can cutdown the tumor vessels and delay tumor growth obviously. After intravenous treatment of RDLPNPs into Hela tumor bearing mice, fluorescent (from DiR) and enhanced photoacoustic (from DLPNPs) signals were found in tumor site over time, which reached to peak at the 6h time point. After irradiating with an NIR laser, a good anti-tumor effect was observed owing to the enhanced photothermal and antiangiogenic effect of RDLPNPs. These results show that the multifunctional nanoparticle can be used as a promising imaging-guided photothermal drug delivery nanoplatform for cancer therapy.

show abstract

Section: Gels Driven By Photothermal Effectmentioning

confidence: 99%

“…Hsiao et al have used in situ formed NIR‐absorbing micellar hydrogels in photothermal tumor ablation . They have designed and synthesized a chitosan derivative functionalized with conjugated polymer polyaniline as side chains.…”

Section: Gels Driven By Photothermal Effectmentioning

confidence: 99%

Soft Materials Driven by Photothermal Effect and Their Applications

Bisoyi

Urbas

2018

Advanced Optical Materials

123

View full text Add to dashboard Cite

Remote driving of functional hybrid soft materials for various applications is emerging as an enabling pursuit. Toward this end, soft materials driven by photothermal agents have been attracting tremendous attention from both fundamental science and technological applications points of view. These stimuli‐responsive materials combine the beneficial attributes of both classes of promising materials, i.e., soft materials and photothermal agents. Both inorganic and organic photothermal agents have been incorporated into the matrices of soft materials. Metal nanoparticles, carbon nanomaterials, and organic photothermal agents have been impregnated into the matrices of liquid crystals, polymers, and gels that can be remotely driven by light irradiation. In this review, the remote driving of functional hybrid soft materials and their various applications are discussed. Photothermal functional nanocomposites are demonstrated to act as actuators, therapeutic agents, drug delivery systems, microvalves, etc. Smart and adaptive systems are realized by dispersing photothermal agents into soft matter matrices. Challenges and opportunities in this fascinating frontier are outlined.

show abstract

Photothermal tumor ablation in mice with repeated therapy sessions using NIR-absorbing micellar hydrogels formed in situ

Cited by 95 publications

References 47 publications

Nanoscale Polymer Metal–Organic Framework Hybrids for Effective Photothermal Therapy of Colon Cancers

Nanoscale Polymer Metal–Organic Framework Hybrids for Effective Photothermal Therapy of Colon Cancers

Rapamycin/DiR loaded lipid-polyaniline nanoparticles for dual-modal imaging guided enhanced photothermal and antiangiogenic combination therapy

Soft Materials Driven by Photothermal Effect and Their Applications

Contact Info

Product

Resources

About