Nanoscale Polymer Metal–Organic Framework Hybrids for Effective Photothermal Therapy of Colon Cancers

Wang, Weiqi; Wang, Lei; Li, Yang; Liu, Shi; Xie, Zhigang; Jing, Xiabin

doi:10.1002/adma.201602997

Cited by 203 publications

(116 citation statements)

References 66 publications

(21 reference statements)

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“…Our own results show improved stability, drug release, and cell-uptake properties with biocompatible PEG chains, and recent work has shown that polyaniline-modified UiO-66 is effective and safe for anticancer photothermal therapy 100 . We expect the versatility of the click modulation protocol to allow a variety of MOFs to be selectively surface functionalized with a variety of chemical units and have immediate application not only in biomedical settings but also in selective adsorption and separation processes and catalysis.…”

Section: Resultsmentioning

confidence: 64%

Selective Surface PEGylation of UiO-66 Nanoparticles for Enhanced Stability, Cell Uptake, and pH-Responsive Drug Delivery

Lázaro

Haddad

Sacca

et al. 2017

Chem

294

158

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SummaryThe high storage capacities and excellent biocompatibilities of metal-organic frameworks (MOFs) have made them emerging candidates as drug-delivery vectors. Incorporation of surface functionality is a route to enhanced properties, and here we report on a surface-modification procedure—click modulation—that controls their size and surface chemistry. The zirconium terephthalate MOF UiO-66 is (1) synthesized as ∼200 nm nanoparticles coated with functionalized modulators, (2) loaded with cargo, and (3) covalently surface modified with poly(ethylene glycol) (PEG) chains through mild bioconjugate reactions. At pH 7.4, the PEG chains endow the MOF with enhanced stability toward phosphates and overcome the “burst release” phenomenon by blocking interaction with the exterior of the nanoparticles, whereas at pH 5.5, stimuli-responsive drug release is achieved. The mode of cellular internalization is also tuned by nanoparticle surface chemistry, such that PEGylated UiO-66 potentially escapes lysosomal degradation through enhanced caveolae-mediated uptake. This makes it a highly promising vector, as demonstrated for dichloroacetic-acid-loaded materials, which exhibit enhanced cytotoxicity. The versatility of the click modulation protocol will allow a wide range of MOFs to be easily surface functionalized for a number of applications.

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Section: Resultsmentioning

confidence: 64%

Selective Surface PEGylation of UiO-66 Nanoparticles for Enhanced Stability, Cell Uptake, and pH-Responsive Drug Delivery

Lázaro

Haddad

Sacca

et al. 2017

Chem

294

158

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“…Regarding cellular assays, coated NPs did not induce any cytotoxicity in both murine colon cancer CT26 and human colon cancer HTC116 cell lines, but once irradiated, nearly 70% cells were dead. In vivo tests carried out with both UiO‐66@PAN and NIR irradiation showed a complete tumor regression after 10 d, when compared to the controls (untreated or NPs alone), proving that UiO‐66@PAN was a good candidate for PTT‐based cancer therapy …”

Section: Surface Modifications Of Nanomofsmentioning

confidence: 89%

“…Numerous strategies have been proposed so far to modify the surface of nanoMOFs using a large variety of molecules, such as nucleic acids, polymers, cyclodextrins (CDs), or lipids, resulting into various degrees of improvement of the particles properties. One can classify these approaches into three categories: covalent, noncovalent, ( Table 2 ) or core–shell, as detailed below.…”

Section: Surface Modifications Of Nanomofsmentioning

confidence: 99%

“…Wang and colleagues also reported nanoscale polymer–MOF hybrids, where the Zr terepthalate UiO‐66 was coated with polyaniline (PAN) (UiO‐66@PAN) for phototermal therapy (PTT) . The photothermal performance of PAN‐coated NPs was investigated and the temperature raised until 57.2 °C at a concentration of 100 µg mL −1 UiO‐66@PAN upon laser irradiation, which was sufficient for the efficient killing of malignant cells.…”

Section: Surface Modifications Of Nanomofsmentioning

confidence: 99%

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Nanoparticles of Metal‐Organic Frameworks: On the Road to In Vivo Efficacy in Biomedicine

et al. 2018

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In the past few years, numerous studies have demonstrated the great potential of nano particles of metal-organic frameworks (nanoMOFs) at the preclinical level for biomedical applications. Many of them were reported very recently based on their bioactive composition, anticancer application, or from a general drug delivery/theranostic perspective. In this review, the authors aim at providing a global view of the studies that evaluated MOFs' biomedical applications at the preclinical stage, when in vivo tests are described either for pharmacological applications or for toxicity evaluation. The authors first describe the current surface engineering approaches that are crucial to understand the in vivo behavior of the nanoMOFs. Finally, after a detailed and comprehensive analysis of the in vivo studies reported with MOFs so far, and considering the general evolution of the drug delivery science, the authors suggest new directions for future research in the use of nanoMOFs for biomedical applications.

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“…Xie and co‐workers combined the zirconium‐based nanoscale MOFs (UiO‐66) and 808 nm NIR‐absorbing polymer (PAN) to construct a UiO‐66@PAN nanocomposite with good photostability, excellent NIR absorbance and outstanding photothermal activity for PTT. The results showed that tumors treated with UiO‐66@PAN+NIR looked like complete regression compared to the control group or the group treated with UiO‐66@PAN, furthermore, the tumor suppression rate was calculated to be about 93% …”

Section: Tumor Therapymentioning

confidence: 99%

Nanoscale Metal‐Organic Frameworks: Synthesis, Biocompatibility, Imaging Applications, and Thermal and Dynamic Therapy of Tumors

Tan

Meng

2020

Adv Funct Materials

132

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Nanoscale metal‐organic frameworks (NMOFs) have attracted increasing attention for biomedical applications due to their large specific surface area, good biocompatibility, adjustable structures, and diverse functions. By choosing appropriate metal ions and ligands, NMOFs can be synthesized and regulated to assist the diagnosis and treatment of cancer, acting as imaging agents, drug carriers, and cancer therapeutic agents. This review summarizes the recent advances of NMOFs in synthesis, biocompatibility, imaging, and applications in cancer therapies. Among these, the term “biocompatibility” is used to outline their various biological characteristics, and it is mainly discussed from the aspects of size and surface properties of NMOFs. The imaging section mainly emphasizes the application advantages of NMOFs as imaging agents in magnetic resonance, computed tomography, and fluorescence imaging. The applications of NMOFs in four cancer therapies, including phototherapy, radiotherapy, microwave therapy, and ultrasonic therapy, are addressed, especially for thermal and dynamic therapy. Finally, the prospects and challenges of NMOFs in imaging and cancer therapies are also discussed.

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Nanoscale Polymer Metal–Organic Framework Hybrids for Effective Photothermal Therapy of Colon Cancers

Cited by 203 publications

References 66 publications

Selective Surface PEGylation of UiO-66 Nanoparticles for Enhanced Stability, Cell Uptake, and pH-Responsive Drug Delivery

Selective Surface PEGylation of UiO-66 Nanoparticles for Enhanced Stability, Cell Uptake, and pH-Responsive Drug Delivery

Nanoparticles of Metal‐Organic Frameworks: On the Road to In Vivo Efficacy in Biomedicine

Nanoscale Metal‐Organic Frameworks: Synthesis, Biocompatibility, Imaging Applications, and Thermal and Dynamic Therapy of Tumors

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