Photothermal effects in connective tissues mediated by laser-activated gold nanorods

Gold nanorods as new nanochromophores for photothermal therapies

“…nine Green (ICG) [8], which is among the most efficient NIR dyes, in good agreement with theoretical predictions [9]. Upon activation, these nanoparticles may be used in manifold applications, such as the near field enhancement for sensing by Raman and luminescence spectroscopy [10]; the contrast enhancement for imaging in different modalities (e.g.…”

Tissue adhesives in ocular surgery

“…NIR-resonant gold nanoshells were mixed into an albumin comprised of solder and applied muscular and cutaneous wounds [195,196]. Ratto et al prepared gold nanorods with an aspect ratio of 4:1 and diameters of 10-15 nm [197]. At this aspect ratio, gold nanorods exhibit a sharp peak absorbance at a wavelength around 810 nm.…”

Human skin penetration of gold nanoparticles through intact and damaged skin

“…In particular, nanoparticles with many different structures, due to their small size (100 nm or less) comparable to that of biological molecules, represent an enormous opportunity in the life sciences and in the medical field. Among these new nanocompounds, gold nanomaterials (AuNPs) are particularly attractive since their valuable size and shape-dependent properties are easy to control and modify; these characteristics offer powerful tools for the activity of the researchers and AuNPs have been proposed for a number of applications in many different fields (Penn et (Rosi et al 2006), in the direct welding of connective tissues (Gobin et al 2005; Ratto et al 2009); but their use has also been proposed as immunostaining marker particles for electron microscopy, chromophores for immunoreactions (Mirkin et al 1996), photocatalyst (Kamat 2002) and Raman sensors (Tian et al 2002). AuNPs are also rising as a lead candidate in the transport of payloads within inside tissues and cells for drug delivery, gene therapy and cell imaging (Ghosh et al 2008).…”