Tissue adhesives in ocular surgery

Park, Heyjin C; Champakalakshmi, Ravi; Panengad, Pradeep P.; Raghunath, Michael; Mehta, Jodhbir S.

doi:10.1586/eop.11.64

Cited by 31 publications

(70 citation statements)

References 188 publications

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“…The Fe‐PAM‐M‐C hydrogel exhibited high tissue adhesive strength on both wet porcine skin and bone surfaces immediately after adhesion (Figure c), which was comparable to that obtained by other commercially available bioadhesives or sealants such as Quixil (24.6 kPa), Beriplast (24.2 kPa), Tachosil (59.6 kPa), and Tisseel (77.5 kPa) . Note that some adhesives have poor adhesion, especially in wet condition, and falls off quickly, such as polyethylene glycol (PEG)‐based adhesive (ReSure, Ocular Therapeutix Inc., USA) . We listed the properties of several typical adhesives in Table S1 in the Supporting Information to clarify the comparisons of our adhesive hydrogel with commercially available adhesives.…”

Section: Resultssupporting

confidence: 57%

Self‐Hydrophobization in a Dynamic Hydrogel for Creating Nonspecific Repeatable Underwater Adhesion

Han

Wang

Prieto‐López

et al. 2019

Adv Funct Materials

171

160

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Adhesive hydrogels are widely applied for biological and medical purposes; however, they are generally unable to adhere to tissues under wet/underwater conditions. Herein, described is a class of novel dynamic hydrogels that shows repeatable and long‐term stable underwater adhesion to various substrates including wet biological tissues. The hydrogels have Fe3+‐induced hydrophobic surfaces, which are dynamic and can undergo a self‐hydrophobization process to achieve strong underwater adhesion to a diverse range of dried/wet substrates without the need for additional processes or reagents. It is also demonstrated that the hydrogels can directly adhere to biological tissues in the presence of under sweat, blood, or body fluid exposure, and that the adhesion is compatible with in vivo dynamic movements. This study provides a novel strategy for fabricating underwater adhesive hydrogels for many applications, such as soft robots, wearable devices, tissue adhesives, and wound dressings.

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Section: Resultssupporting

confidence: 57%

Self‐Hydrophobization in a Dynamic Hydrogel for Creating Nonspecific Repeatable Underwater Adhesion

Han

Wang

Prieto‐López

et al. 2019

Adv Funct Materials

171

160

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“…Tissue adhesives have been developed and applied since the 19 th century [2]. At that time, methyl-2-cyanoacrylate was the first tissue adhesive used for surgical application.…”

Section: History Of Tissue Adhesivesmentioning

confidence: 99%

“…Second, the adhesive should be able to polymerize in a moist environment within a reasonable curing time [1,2]. Third, the adhesive must be steadily metabolized by the surrounding tissue without generating an inflammatory response or be a site for infection [1,6].…”

Section: Potential Areas Of Researchmentioning

confidence: 99%

“…Third, the adhesive must be steadily metabolized by the surrounding tissue without generating an inflammatory response or be a site for infection [1,6]. Lastly, the adhesive should not deform the tissue and cause discomfort to the patient postoperatively [1,2]. All of these features are what all tissue adhesives should essentially share in common.…”

Section: Potential Areas Of Researchmentioning

confidence: 99%

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Characterization of silver nanoparticle-infused tissue adhesive for ophthalmic use

Yee

Selvaduray

Hawkins

2016

Journal of the Mechanical Behavior of Biomedical Materials

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This research examined if the infusion of silver nanoparticles into a 2-octyl cyanoacrylate tissue adhesive alters the antibacterial effectiveness and mechanical properties of the adhesive. Silver nanoparticle size and concentration combinations were varied to determine the effects of these factors. Uniform distribution of the silver nanoparticles was achieved before proceeding to testing. Antibacterial effectiveness of the composite adhesive was determined via the Kirby-Bauer disk diffusion susceptibility test and by CFU counting. Doping the adhesive with silver nanoparticles resulted in an order of magnitude reduction in bacterial growth. The greatest antibacterial effect came from imbuing 10 μg/mL of 4 nm silver nanoparticles into the tissue adhesive. Despite the noticeable reduction of bacterial growth for the doped adhesives, the difference among the varying silver nanoparticle size and concentration combinations was minimal.The breaking strength of the adhesive increased when silver nanoparticles were added. The adhesive strength of the composite adhesive attached to an incised porcine sclera was also greater than the unaltered adhesive. The greatest breaking load and adhesive force was the 10 μg/mL of 10 nm silver nanoparticle-doped adhesive. The

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“…Tissue adhesives have been used in ophthalmic surgery since the early 20th century. 1,2 They are broadly divided into two classes: synthetic and biological adhesives. Cyanoacrylate adhesives are one of the most common synthetic adhesives used in ocular surgery since 1963.…”

Section: Introductionmentioning

confidence: 99%