Photothermal effect by NIR-responsive excretable ultrasmall-in-nano architectures

Cassano, Domenico; Santi, Melissa; D’Autilia, Francesca; Mapanao, Ana Katrina; Luin, Stefano; Voliani, Valerio

doi:10.1039/c9mh00096h

Cited by 53 publications

(58 citation statements)

References 36 publications

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“…Remarkably, NAs are non-persistent noble metalbased nano-architectures of special interest for oncology and infectious disease treatment. [12][13][14][15] Their (bio)degradation to excretable building blocks has already been demonstrated together with their biosafety features at therapeutic concentrations in different vertebrate models. [16][17][18] Overall, these ndings reinforce the clinical applicability of noble metal-based nanotherapeutics and provide useful evidence on the risks associated with pulmonary exposure to nanomaterials.…”

Section: Introductionmentioning

confidence: 99%

Biokinetics and clearance of inhaled gold ultrasmall-in-nano architectures

et al. 2020

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Section: Introductionmentioning

confidence: 99%

Biokinetics and clearance of inhaled gold ultrasmall-in-nano architectures

et al. 2020

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“…GNPs display a great potential for various biomedical applications due to their excellent physicochemical properties. One of the most promising applications of GNPs is NIR-induced PTT of cancer, wherein Surface Plasmon Resonance (SPR) of GNPs enables an efficient conversion of NIR irradiation into thermal energy [6][7][8]. In addition, GNPs appear excellent for targeted drug delivery [8] and even immune modulation [35].…”

Section: Discussionmentioning

confidence: 99%

“…Astonishing progress has been made in the biomedical application of gold nanoparticles (GNPs), demonstrated by a large increase in the number of publications in the last few years [1][2][3]. GNPs coupled with various molecules have been investigated extensively as a multifunctional platform for cellular imaging [4], biosensing [5] and targeted drug delivery in tumour immunotherapy and photothermal therapy [6][7][8]. Due to the chemically inert nature of Au, GNPs are expected to be biocompatible, as we demonstrated previously [9], along with several other groups [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Stabilisation Agents on the Immunomodulatory Properties of Gold Nanoparticles Obtained by Ultrasonic Spray Pyrolysis

et al. 2019

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Gold nanoparticles (GNPs) have been investigated extensively as drug carriers in tumour immunotherapy in combination with photothermal therapy. For this purpose, GNPs should be stabilised in biological fluids. The goal of this study was to examine how stabilisation agents influence cytotoxicity and immune response in vitro. Spherical GNPs, 20 nm in size, were prepared by ultrasonic spray pyrolysis (USP). Three types of stabilising agents were used: sodium citrate (SC), polyvinyl-pyrrolidone (PVP), and poly-ethylene glycol (PEG). Pristine, non-stabilised GNPs were used as a control. The culture models were mouse L929 cells, B16F10 melanoma cells and human peripheral blood mononuclear cells (PBMNCs), obtained from healthy donors. Control SC- and PEG-GNPs were non-cytotoxic at concentrations (range 1–100 µg/mL), in contrast to PVP-GNPs, which were cytotoxic at higher concentrations. Control GNPs inhibited the production of IFN-ϒ slightly, and augmented the production of IL-10 by PHA-stimulated PBMNC cultures. PEG-GNPs inhibited the production of pro-inflammatory cytokines (IL-1, IL-6, IL-8, TNF-α) and Th1-related cytokines (IFN-ϒ and IL-12p70), and increased the production of Th2 cytokines (IL-4 and IL-5). SC-PEG inhibited the production of IL-8 and IL-17A. In contrast, PVP-GNPs stimulated the production of pro-inflammatory cytokines, Th1 cytokines, and IL-17A, but also IL-10. When uptake of GNPs by monocytes/macrophages in PBMNC cultures was analysed, the ingestion of PEG- GNPs was significantly lower compared to SC- and PVP-GNPs. In conclusion, stabilisation agents modulate biocompatibility and immune response significantly, so their adequate choice for preparation of GNPs is an important factor when considering the use of GNPs for application in vivo.

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“…For further biomedical applications, the studies would perform with physiological-like fluids [27]. Here, the hydrolytic degradation of the polymers was performed in pH 7.4 PBS at 37 • C. Figure 1a shows the evolution of the remaining weight of the linear-comb diblock copolymers as well as their homopolymers during 84 day-degradation.…”

Section: Weight Retention and Water Absorptionmentioning

confidence: 99%

Hydrolytic Degradation of Comb-Like Graft Poly (Lactide-co-Trimethylene Carbonate): The Role of Comonomer Compositions and Sequences

et al. 2019

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The effect of sequence on copolymer properties is rarely studied, especially the degradation behavior of the biomaterials. A series of linear-comb block, gradient, random copolymers were successfully achieved using hydroxylated polybutadiene as the macroinitiator by simple ring-opening polymerization of l-lactide (l-LA) and 1,3-trimethylene carbonate (TMC). The hydrolytic degradation behaviors of the copolymers were systemically evaluated by using nuclear magnetic resonance (NMR), gel permeation chromatography (GPC), differential scanning calorimeter (DSC), and scanning electron microscopy (SEM) to illustrate the influences of comonomer compositions and sequence structures. The linear-comb block copolymers (lcP(TMC-b-LLA)) with different compositions had different degradation rates, which increased with l-LA content. Thermal property changes were observed with decreased Tm and increased ΔHm in all block copolymers during the degradation. To combine different sequence structures, unique degradation behaviors were observed for the linear-comb block, gradient and random copolymers even with similar comonomer composition. The degradation rates of linear-comb PLLA-gradient-PTMC (lcP(LLA-grad-TMC)) and linear-comb PLLA-random-PTMC (lcP(LLA-ran-TMC)) were accelerated due to the loss of regularity and crystallinity, resulting in a remarkable decrease on weight retention and molar mass. The hydrolysis degradation rate increased in the order lcP(TMC-b-LLA), lcP(LLA-ran-TMC), lcP(LLA-grad-TMC). Therefore, the hydrolytic degradation behavior of comb-like graft copolymers depends on both the compositions and the sequences dramatically.

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Photothermal effect by NIR-responsive excretable ultrasmall-in-nano architectures

Cited by 53 publications

References 36 publications

Biokinetics and clearance of inhaled gold ultrasmall-in-nano architectures

Biokinetics and clearance of inhaled gold ultrasmall-in-nano architectures

The Effect of Stabilisation Agents on the Immunomodulatory Properties of Gold Nanoparticles Obtained by Ultrasonic Spray Pyrolysis

Hydrolytic Degradation of Comb-Like Graft Poly (Lactide-co-Trimethylene Carbonate): The Role of Comonomer Compositions and Sequences

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