Photothermal effect and cytotoxicity of CuS nanoflowers deposited over folic acid conjugated nanographene oxide

Neelgund, Gururaj M.; Oki, Aderemi; Bandara, Subhani; Carson, Laura

doi:10.1039/d0tb02366c

Cited by 19 publications

(11 citation statements)

References 63 publications

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“…In addition, 1694 cm −1 peak (C=O stretching vibration) of FA was free carbonyl group, but this peak shifted to 1638 cm −1 (C=O stretching vibration of amide peak (I)) of FA-modified siRNA/PEI@PDA. And FA-modified siRNA/PEI@PDA also had characteristic amide NH peak (II) at 1534 cm −1 , indicating FA was successfully modified on the surface of PDA nanomedicine [ 35 , 36 ]. The particle size and zeta potential of the siRNA/PEI NPs, siRNA/PEI-loaded PDA nanomedicine and FA-modified siRNA/PEI-loaded PDA nanomedicine were also measured.…”

Section: Resultsmentioning

confidence: 99%

A polydopamine nanomedicine used in photothermal therapy for liver cancer knocks down the anti-cancer target NEDD8-E3 ligase ROC1 (RBX1)

Zhang

Tian

et al. 2021

J Nanobiotechnol

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Knocking down the oncogene ROC1 with siRNA inhibits the proliferation of cancer cells by suppressing the Neddylation pathway. However, methods for delivering siRNA in vivo to induce this high anticancer activity with low potential side effects are urgently needed. Herein, a folic acid (FA)-modified polydopamine (PDA) nanomedicine used in photothermal therapy was designed for siRNA delivery. The designed nanovector can undergo photothermal conversion with good biocompatibility. Importantly, this genetic nanomedicine was selectively delivered to liver cancer cells by FA through receptor-mediated endocytosis. Subsequently, the siRNA cargo was released from the PDA nanomedicine into the tumor microenvironment by controlled release triggered by pH. More importantly, the genetic nanomedicine not only inhibited liver cancer cell proliferation but also promoted liver cell apoptosis by slowing ROC1 activity, suppressing the Neddylation pathway, enabling the accumulation of apototic factor ATF4 and DNA damage factor P-H2AX. Combined with photothermal therapy, this genetic nanomedicine showed superior inhibition of the growth of liver cancer in vitro and in vivo. Taken together, the results indicate that this biodegradable nanomedicine exhibits good target recognition, an effective pH response, application potential for genetic therapy, photothermal imaging and treatment of liver cancer. Therefore, this work contributes to the design of a multifunctional nanoplatform that combines genetic therapy and photothermal therapy for the treatment of liver cancer.

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Section: Resultsmentioning

confidence: 99%

A polydopamine nanomedicine used in photothermal therapy for liver cancer knocks down the anti-cancer target NEDD8-E3 ligase ROC1 (RBX1)

Zhang

Tian

et al. 2021

J Nanobiotechnol

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“…208 Third, only when the size of the photothermal agent is small enough can it enter the tissue cells for photothermal therapy, so it must have superior tissue targeting. 209 At present, widely used photothermal materials include noble metal nanoparticles such as Au, Ag and Pt, 210,211 carbon materials such as graphene and carbon nanorods, 212 metal and nonmetal compounds such as CuS and ZnS, 213 and organic dyes such as indocyanine green and Prussian blue, 214 while few studies have mentioned CQDs. CuS nanoparticles carrying CQDs and bortezomib were synthetized, coated with macrophage membranes and modified with the T7 peptide to form CuSCDB@MMT7.…”

Section: Photothermal Therapymentioning

confidence: 99%

Recent Advances in Functional Carbon Quantum Dots for Antitumour

Cai¹,

Xiao²,

Liu³

et al. 2021

IJN

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Carbon quantum dots (CQDs) are an emerging class of quasi-zero-dimensional photoluminescent nanomaterials with particle sizes less than 10 nm. Owing to their favourable water dispersion, strong chemical inertia, stable optical performance, and good biocompatibility, CQDs have become prominent in biomedical fields. CQDs can be fabricated by "top-down" and "bottom-up" methods, both of which involve oxidation, carbonization, pyrolysis and polymerization. The functions of CQDs include biological imaging, biosensing, drug delivery, gene carrying, antimicrobial performance, photothermal ablation and so on, which enable them to be utilized in antitumour applications. The purpose of this review is to summarize the research progress of CQDs in antitumour applications from preparation and characterization to application prospects. Furthermore, the challenges and opportunities of CQDs are discussed along with future perspectives for precise individual therapy of tumours.

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“…As a plasmonic material, it absorbs near-infrared (NIR) light and converts it into heat due to d-d transition of copper ion and non-radiative relaxation [ 17 ]. The broad absorption in the NIR region has made Cu 2-x S, such as CuS, Cu 2 S, and Cu 7 S 4 , great candidates in the photothermal field [ 18 , 19 , 20 ]. For instance, researchers have found that under irradiation of 980 nm, modified-CuS nanoflowers were able to attain a temperature of 63.1 °C within 5 min [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

“…The broad absorption in the NIR region has made Cu 2-x S, such as CuS, Cu 2 S, and Cu 7 S 4 , great candidates in the photothermal field [ 18 , 19 , 20 ]. For instance, researchers have found that under irradiation of 980 nm, modified-CuS nanoflowers were able to attain a temperature of 63.1 °C within 5 min [ 18 ]. In particular, Cu 2 S has the features of low cost, abundance, recyclability, low toxicity, good stability, and intrinsic plasmonic properties [ 21 ], leading to uses in the fields of electronics, optoelectronics, photoelectrochemicals, biosensors, and photothermal materials.…”

Section: Introductionmentioning

confidence: 99%

Controlled Growth Cu2S Nanoarrays with High-Performance Photothermal Properties

Miao

Zhou

et al. 2023

Nanomaterials

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The controlled growth of Cu2S nanoarrays was constructed by a facile two-step impregnation synthesis route. The as-synthesized Cu2S/CuO@Cu samples were precisely characterized in terms of surface morphology, phase, composition, and oxidation states. At the laser irradiation of 808 nm, Cu2S/CuO@Cu heated up to 106 °C from room temperature in 120 s, resulting in an excellent photothermal conversion performance. The Cu2S/CuO@Cu exhibited excellent cycling performance—sustaining the photothermal performance during five heating-cooling cycles. The finite difference time domain (FDTD) simulation of optical absorption and electric field distributions assured the accuracy and reliability of the developed experimental conditions for acquiring the best photothermal performance of Cu2S/CuO@Cu.

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Photothermal effect and cytotoxicity of CuS nanoflowers deposited over folic acid conjugated nanographene oxide

Abstract: Herein, we present the rational synthesis of a multimode photothermal agent, NGO–FA–CuS, for the advancement of photothermal therapy of cancer.

Cited by 19 publications

References 63 publications

A polydopamine nanomedicine used in photothermal therapy for liver cancer knocks down the anti-cancer target NEDD8-E3 ligase ROC1 (RBX1)

A polydopamine nanomedicine used in photothermal therapy for liver cancer knocks down the anti-cancer target NEDD8-E3 ligase ROC1 (RBX1)

Recent Advances in Functional Carbon Quantum Dots for Antitumour

Controlled Growth Cu2S Nanoarrays with High-Performance Photothermal Properties

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