Recent Advances in Functional Carbon Quantum Dots for Antitumour

Cai, Rong; Xiao, Long; Liu, Meixiu; Du, F.

doi:10.2147/ijn.s334012

Cited by 21 publications

(13 citation statements)

References 253 publications

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“…functionalized can minimize cytotoxicity caused by drug leakage into normal cells. Amino groups on the surfaces of functionalized CQDs are employed to crosslink with tumor theranostics (Cai et al, 2021). CQDs formed by microwave pyrolysis of citric acid cross-linked with PEGylated oxidized alginate and subsequently conjugated with theranostic doxorubicin (DOX) via acid-labile Schiff base connection.…”

Section: Drug Deliverymentioning

confidence: 99%

Recent Advances on Synthesis and Potential Applications of Carbon Quantum Dots

2022

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Fluorescent carbon nanoparticles also termed as carbon quantum dots (CQDs) have attracted so much interest when compared to the traditional semiconductor quantum dots due to their applications in chemical sensing, biomedical imaging, nanotechnology, photovoltaics, light-emitting diodes (LEDs), and electrochemistry. Along with their optical features, CQDs have desired properties such as less toxicity, environmentally friendly nature, inexpensive, and simple preparation processes. In addition, CQDs can have their physical and chemical properties controlled by surface passivation and functionalization. This article provides an account of CQDs because of their distinct characteristics and considerable capacity in diverse applications. The article is categorized into various sections that highlight various synthesis methodologies of CQDs with their advantages/disadvantages and their potential applications in sensors, bio-imaging, drug delivery, solar cells, and supercapacitors. The different applications of CQDs can be demonstrated by controlled synthesis methods. We have also discussed gas sensing applications of CQDs briefly and provided a brief overview of osmotic power generation using CQDs for energy applications.

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Section: Drug Deliverymentioning

confidence: 99%

Recent Advances on Synthesis and Potential Applications of Carbon Quantum Dots

2022

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“…After the tail vein administration of CPCaNPs, the photoacoustic signal at the tumor site gradually increased until it peaked at 24 h and then decreased at 48 h. What is more, the PA intensity of the tumor site in the CPCaNP group was significantly higher than that of the PCaNP group at 24 h (Figure 4A,B). The in vivo ultrasonography results proved that the injection of CPCaNPs enhanced the CEUS signal in the tumor site compared with PCaNPs at 24 h (Figure 4C with black phosphorus, 58 MXenes, 22 carbon-based materials, 59 and other novel nanoplatforms, tumor microenvironment response and homologous targeting ability of biocompatible CPCaNPs provide double insurance for accurate photothermal treatment. Simultaneously, photoacoustic, ultrasound, and thermal imaging monitoring contributes to the clinical translation of precise PTT based on CPCaNPs.…”

Section: 5mentioning

confidence: 57%

“…The temperature of the CPCaNP group in the tumor region risen by 19.8 °C rapidly and by 10.4 °C in the PCaNP group, while the temperature of the phosphate-buffered saline (PBS) group only risen by 6.4 °C (Figure 4E,F). Compared with black phosphorus, 58 MXenes, 22 carbon-based materials, 59 and other novel nanoplatforms, tumor microenvironment response and homologous targeting ability of biocompatible CPCaNPs provide double insurance for accurate photothermal treatment. Simultaneously, photoacoustic, ultrasound, and thermal imaging monitoring contributes to the clinical translation of precise PTT based on CPCaNPs.…”

Section: 5mentioning

confidence: 99%

Biomimetic, pH-Responsive Nanoplatforms for Cancer Multimodal Imaging and Photothermal Immunotherapy

Wan

Cao

Chen

et al. 2022

ACS Appl. Mater. Interfaces

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Photothermal therapy (PTT), by converting light to thermal energy, has become a novel and noninvasive technique for tumor thermal ablation in clinical practice. However, as a result of phagocytosis of reticuloendothelial cells, current photothermal agents (PTAs) derived from exogenous materials suffer from incompetent tumor targeting and brief internal circulation time. The resulting poor accumulation of PTAs in the target area severely reduces the efficacy of PTT. In addition, the potential toxicity of PTAs, excessive laser exposure, and possibilities of tumor recurrence and metastasis following PTT are still intractable problems that severely influence patients' quality of life. Herein, a biomimetic pH-responsive nanoprobe was prepared via cancer cell membrane coating polydopamine (PDA)−CaCO 3 nanoparticles (CPCaNPs) for photoacoustic (PA)/ultrasonic (US)/thermal imaging-guided PTT. When CPCaNPs targeted and infiltrated into the tumor's acidic microenvironment, the decomposed CO 2 bubbles from homologous targeting CPCaNPs enhanced ultrasonic (US) signals obviously. At the same time, the PDA of CPCaNPs not only performed efficient PTT of primary tumors but also generated photoacoustic (PA) signals. In addition, an immune checkpoint pathway blockade was combined, which inhibited tumor recurrence and metastasis significantly and improved the immunosuppressive microenvironment after PTT to a large extent. Thus, these proposed biomimetic pH-responsive CPCaNPs provide a promising strategy for precise PTT immunotherapy under the intelligent guidance of PA/US/thermal imaging and show great potential for clinical translation.

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“…CQDs (C‐dots, or CDs) are nanomaterials composed of carbon, hydrogen, oxygen, and nitrogen, with a particle size <10 nm. 304 , 305 , 306 , 307 , 308 CDs not only possess excellent photostability and efficient catalytic ability but also have surface modification flexibility. Based on the fluorescence ability of CDs, multifunctional CDs are covalently modified the free amine and hydroxyl groups.…”

Section: Backbones and Structures Of Multifunctional Nanoparticlesmentioning

confidence: 99%

Multifunctional nanoparticle for cancer therapy

Wang

Zhang

Duan

et al. 2023

MedComm

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Cancer is a complex disease associated with a combination of abnormal physiological process and exhibiting dysfunctions in multiple systems. To provide effective treatment and diagnosis for cancer, current treatment strategies simultaneously focus on various tumor targets. Based on the rapid development of nanotechnology, nanocarriers have been shown to exhibit excellent potential for cancer therapy. Compared with nanoparticles with single functions, multifunctional nanoparticles are believed to be more aggressive and potent in the context of tumor targeting. However, the development of multifunctional nanoparticles is not simply an upgraded version of the original function, but involves a sophisticated system with a proper backbone, optimized modification sites, simple preparation method, and efficient function integration. Despite this, many well‐designed multifunctional nanoparticles with promising therapeutic potential have emerged recently. Here, to give a detailed understanding and analyzation of the currently developed multifunctional nanoparticles, their platform structures with organic or inorganic backbones were systemically generalized. We emphasized on the functionalization and modification strategies, which provide additional functions to the nanoparticle. We also discussed the application combination strategies that were involved in the development of nanoformulations with functional crosstalk. This review thus provides an overview of the construction strategies and application advances of multifunctional nanoparticles.

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Recent Advances in Functional Carbon Quantum Dots for Antitumour

Cited by 21 publications

References 253 publications

Recent Advances on Synthesis and Potential Applications of Carbon Quantum Dots

Recent Advances on Synthesis and Potential Applications of Carbon Quantum Dots

Biomimetic, pH-Responsive Nanoplatforms for Cancer Multimodal Imaging and Photothermal Immunotherapy

Multifunctional nanoparticle for cancer therapy

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