Phototherapeutic potential of alternative photosensitizers to porphyrins

Laser Photo Chemotherapy: An Alternative Treatment for Cancer

“…These drugs may be injected intravenously at concentrations lower than normal chemotherapeutic levels, or at higher intratumor doses reducing systemic toxicity while enhancing local tumoricidal effects by laser photoactivation in situ (Nahabedian et al, 1988;Paiva et al, 1998c). Other anthracyclines have also been identified that have greater photosensitization potential than daunomyucin (Diwu and Lown, 1994). With all the supporting evidence of translational studies, photochemotherapy has been established as an alternative treatment for retinoblastoma (Peterson et al, 2011).…”

“…Several FDA approved anti-cancer drugs are highly photosensitive or heat-responsive, including anthracycline derivatives and cisplatin Graeber et al, 1999). This experimental technique broadens the concept of tumor ablation based on thermal denaturation of malignant cells to include anti-cancer drug activation by laser energy (Chung et al, 2000;Diwu and Lown, 1994;Nahabedian et al, 1988). A major development is already taking place in photo chemotherapy as computermodeled nanoproducts have proven to be ''intelligently-guided'' by heat sensitization.…”

“…Nevertheless, these chemotherapy agents are the most tested in hopes of enhancing three distinct anti-cancer effects when combined with visible light: photo toxicity, thermal-toxicity and chemotherapy per se . Recent attempts to reduce anthracycline toxicity led to the development of a variety of anthrapyrazole derivatives including DUP-941 (CI-941), which possess reduced side effects but has been shown to retain clinical efficacy in breast cancer patients (Diwu and Lown, 1994). An unusual property of DUP-941 is that it has an over 100-fold increased photooxidation potential compared to anthracyclines as reported by Reszka et al (1992).…”

A Potential Visible-Light NO Releaser: Synthesis, Reactivity and Vasodilator Properties

“…This spectroscopic range falls within the phototherapeutic window, where light has the greatest penetrating capacity in the skin, and could hence be useful as a non-invasive clinical therapy. 57,58 Even though this range is routinely investigated in the search for photoactivatable metal complexes and appropriate light sources are available, there is also interest in using other wavelengths in the treatment of superficial tumors and development of appropriate light source. For example, blue light is already being successfully employed in therapy.…”

Efeitos do meio e da interação com DNA e Micelas nas características espectrais dos corantes ciânicos com dois cromóforos

“…Entre estes estão os derivados de benzoporfirinas, clorinas, ftalocianinas e corantes ciânicos, entre outros [8].…”