Photosensitive chitosan to control cell attachment

Cheng, Nan; Cao, Xudong

doi:10.1016/j.jcis.2011.05.045

Cited by 15 publications

(11 citation statements)

References 45 publications

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“…Chitosan is derived from chitin with a linear structure, consisting of β -(1–4)-linked 2-amino-2-deoxy- D -glucose and 2-acetamido-2-deoxy- D -glucose units [30]. Chitosan can be easily modified, usually via primary amine groups [31]. However, Chitosan can only be dissolved in an acetic environment, which limits its applications in injectable cell culture scaffolds.…”

Section: Preparation and Characterization Of Hydrogelsmentioning

confidence: 99%

Development of Hydrogels and Biomimetic Regulators as Tissue Engineering Scaffolds

2012

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This paper reviews major research and development issues relating to hydrogels as scaffolds for tissue engineering, the article starts with a brief introduction of tissue engineering and hydrogels as extracellular matrix mimics, followed by a description of the various types of hydrogels and preparation methods, before a discussion of the physical and chemical properties that are important to their application. There follows a short comment on the trends of future research and development. Throughout the discussion there is an emphasis on the genetic understanding of bone tissue engineering application.

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Section: Preparation and Characterization Of Hydrogelsmentioning

confidence: 99%

Development of Hydrogels and Biomimetic Regulators as Tissue Engineering Scaffolds

2012

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“…Another disadvantage of these compounds is their solubility in organic solvents, which are generally not accepted in medical applications. The solution to these problems is the introduction of these compounds into the polymer matrix in the process of chemical or physical modification, e.g., by immobilization on the polymer surface as well as preparation of photosensitizer–polymer nanoparticles [ 23 , 24 , 25 , 26 , 27 , 28 ]. When such a system is intended for biomedicine, it is very important to choose a type of polymer that cannot interact with the human body or cause allergies.…”

Section: Introductionmentioning

confidence: 99%

Fluorescent Chitosan Modified with Heterocyclic Aromatic Dyes

et al. 2021

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Chitosan is a valuable, functional, and biodegradable polysaccharide that can be modified to expand its applications. This work aimed to obtain chitosan derivatives with fluorescent properties. Three heterocyclic aromatic dyes (based on benzimidazole, benzoxazole, and benzothiazole) were synthesized and used for the chemical modification of chitosan. Emission spectroscopy revealed the strong fluorescent properties of the obtained chitosan derivatives even at a low N-substitution degree of the dye. The effect of high-energy ultraviolet radiation (UV–C) on modified chitosan samples was studied in solution with UV–Vis spectroscopy and in the solid state with FTIR spectroscopy. Moreover, cytotoxicity towards three different cell types was evaluated to estimate the possibilities of biomedical applications of such fluorescent chitosan-based materials. It was found that the three new derivatives of chitosan were characterized by good resistance to UV–C, which suggests the possibility of using these materials in medicine and various industrial sectors.

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“…By manipulating its primary amine groups, chitosan can improve its solubility under physiological conditions. 41 For example, N-succinate can be introduced into chitosan (S-chi) to make it dissolvable in a neutral environment. 42 Alginate is a block polymeric polysaccharide, composed of (1-4)linked b-D-mannuronic acid (M units) and α-L-guluronic acid (G units) monomers with various ratios between M and G units.…”

Section: Introductionmentioning

confidence: 99%

Schiff based injectable hydrogel for in situ pH-triggered delivery of doxorubicin for breast tumor treatment

et al. 2014

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In this study, we report a facile approach to develop an injectable hydrogel with an in situ and pH sensitive drug delivery system for cancer treatment. The hydrogel was based on modified chitosan and alginate. We conjugated doxorubicin (DOX) to succinated chitosan (S-chi) via a Schiff base between a ketone group in the DOX and an amine group in the S-chi, which led to a pH sensitive release of DOX upon the stimulus of an acidic tumor microenvironment. Hydrogel formed in minutes while DOX conjugated S-chi was mixed with oxidized alginate. The hydrogel structure was characterized by cryo-imaging, FTIR and a rheology test. The DOX release profiles were tested in response to different pH values. The MTT assay showed a low toxicity of the hydrogel. The gel in turn inhibited the growth of tumor cells MCF-7 effectively when loaded with DOX. Finally, the DOX laden hydrogel was injected into the xenograft breast tumor model and significantly inhibited tumor growth.

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Photosensitive chitosan to control cell attachment

Cited by 15 publications

References 45 publications

Development of Hydrogels and Biomimetic Regulators as Tissue Engineering Scaffolds

Development of Hydrogels and Biomimetic Regulators as Tissue Engineering Scaffolds

Fluorescent Chitosan Modified with Heterocyclic Aromatic Dyes

Schiff based injectable hydrogel for in situ pH-triggered delivery of doxorubicin for breast tumor treatment

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