Development of Hydrogels and Biomimetic Regulators as Tissue Engineering Scaffolds

Shi, Junbin; Xing, Malcolm; Zhong, Wen

doi:10.3390/membranes2010070

Cited by 42 publications

(41 citation statements)

References 119 publications

(197 reference statements)

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“…Cross-linked polymers are being investigated at a tremendous rate for numerous applications in controlled release, sustained release, targeted drug delivery, protective drug release, and tissue engineering. [1][2][3] The hydrogel networks can be fabricated from a wide range of monomers, polymers (natural or synthetic origin), biodegradable, nonbiodegradable, or combinations of both. The resulting cross-linked polymeric systems impart extensive diversity in terms of bulk physical properties.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Biodegradable Hydrogels for Oral Delivery of 5‐Fluorouracil Targeted to Colon: Screening with Preliminary In Vivo Studies

et al. 2016

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ABSTRACT:In this communication, we developed a thermally stable, biocompatible, and colonically degradable hydrogel-based device [pectin-co-poly(MAA)] for oral delivery of 5-fluorouracil (5-FU) to treat colon cancer with minimal upper gastrointestinal invasion. Toward this end, ethylene glycol dimethacrylate (EGDMA) cross-linked hydrogels of pectin were synthesized. Methacrylic acid (MAA) was grafted to impart pH-responsive character, whereas benzoyl peroxide (BPO) was applied for simultaneous grafting and cross-linking polymerization. The hydrogels were characterized by Fourier transform infrared , thermogravimetric analysis, differential scanning calorimetry, and X-ray diffractometry. Scanning electron microscopic photographs were taken to analyze the surface morphology. Swelling behavior was analyzed to assess better performance of biodegradable hydrogels for optimized loading and release of the drug targeted to the colon. Gel fraction, swelling ratio, diffusion coefficient, drug loading, and cumulative release increased with an increase of pectin ratio and decreased with an increase of MAA and EGDMA ratio. Strategically, hydrogels with higher amounts of pectin were prepared for complete degradation in the colon. Our investigations indicate that pectin-co-poly(MAA) hydrogel is a suitable delivery system developed for oral delivery of the drug targeted to the colon. C

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Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Biodegradable Hydrogels for Oral Delivery of 5‐Fluorouracil Targeted to Colon: Screening with Preliminary In Vivo Studies

et al. 2016

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“…25 However, existing synthetic and natural materials for POP treatment in clinics cannot fully meet these requirements, as shown by 1) the high dyspareunia, infection, and erosion or extrusion rate resulting from the synthesis scaffolds and 2) the rapid degradation of natural scaffolds. [9][10][11][12][13][14][15][16] To overcome these problems, we constructed a composite nanofibrous membrane by electrospinning nanofibers with a PS core embedded in a gelatin sheath as a potential POP.…”

Section: Resultsmentioning

confidence: 99%

“…16 This may be attributed to the natural biomaterial coating that can reduce the immune reaction provoked by the synthetic materials. 16,25,35 Futhermore, we detected T helper (Th) and macrophage (M1 and M2) reaction during implantation through immunochemical and gene expression analysis, because these cells can be characterized as Th1 or Th2 phenotype, M1 or M2 phenotype based on receptor expression and production of cytokines and effector molecules. These cells play critical roles in determining immune tolerance or immune rejection function.…”

mentioning

confidence: 99%

Integration of nondegradable polystyrene and degradable gelatin in a core–sheath nanofibrous patch for pelvic reconstruction

Ge¹,

Jiang

et al. 2015

IJN

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Pelvic organ prolapse (POP) is a serious health issue affecting many adult women. Complications of POP include pelvic pressure, pelvic pain, and problems in emptying their bowels or bladder. Sometimes, POP may even cause urinary outflow obstruction and lead to bladder or kidney infections. Currently, synthetic and naturally derived materials have been chosen for treatment of POP to reduce the high recurrence rates after surgical interventions. However, existing materials for POP treatment cannot meet the clinical requirements in terms of biocompatibility, mechanics, and minimal risk of rejection. Especially, erosion in synthetic polymers and rapid degradation in natural polymers limit their further applications in clinics. To address these concerns, we report a novel POP replacement using core–sheath polystyrene/gelatin electrospun nanofiber mesh. The outside gelatin sheath provides a hydrophilic surface and implantable integrity between host and guest, while the inner PS core offers the necessary mechanical support. The composite mesh shows graft accommodation in pelvic submucosa after implantation in vivo, as shown in hematoxylin–eosin staining and T helper cell phenotype and macrophage phenotype stainings. Qualitative analysis of inducible nitric oxide synthase, arginase, interferon-γ, and interleukin-10 gene expressions also indicates that the implanted composite mesh switches to accommodation mode 2 weeks postimplantation. Thus, these novel core–sheath polystyrene/gelatin nanofibrous membranes are promising in pelvic reconstruction.

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“…The ultrasound showed to be an appropriate tool to assess the product behavior in vivo, since it allows its localization and measurement, in addition to being a painless and non-invasive method [16][17][18][19][20][21][22][23][24][25][26][27]. Its durability in up to 01 year after application is demonstrated because no significant reduction in the volume deposited in the procedure location was observed.…”

Section: Ultrasoundmentioning

confidence: 97%

“…Its permanence in the application location has shown very low level of absorption, keeping significant clinical improvement [17].…”

Section: Assessment Of Cutaneous Relief With Primos Equipmentmentioning

confidence: 99%

Injectable Polyethylene Glycol Gel as Dermal Filler: 01 Year Clinical and Ultrasound Follow-Up

Addor¹,

Neri²

2016

J Clin Exp Dermatol Res

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Facial alterations that occur with aging are result of combined effects of soft tissue atrophy with loss of facial volume, gravitational factor and decrease of elastic tissue. In order to minimize these alterations, minimally invasive procedures such as cutaneous filling have been gaining space in clinical practice. In 2008, Scientech CorporationItalia introduced hydrogel of polyethylene glycol (PEG) REMAKE ® as cutaneous filler. This prospective study was developed to prove the effectiveness, safety and durability over the 12 months after the application of PEG hydrogel, commercialized under the name of REMAKE ® . 40 female volunteers were included, between 30 and 60 years, with signs of malar region volume loss between 2 and 3 (Raspaldo's classification) and Nasogenian furrow accentuation, with score between 2 and 3 (Day and collaborators' classification). No patient had carried out procedures of temporary filling for 1 year or permanent filling at any time. Objective parameters always show the scale of the improvement and an evaluation was selected through ultrasound exams and surface scan for evaluation of size and depth of wrinkles improvement. Evaluations by the US were carried out for 30, 120 and 360 days of product use, in a pilot group of 18 patients randomly selected to measure the product in the application plan and numerically assess alterations of volume (absorption/migration). Its durability of up to 01 year after application is proved when no significant reduction.

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Development of Hydrogels and Biomimetic Regulators as Tissue Engineering Scaffolds

Cited by 42 publications

References 119 publications

Synthesis and Characterization of Biodegradable Hydrogels for Oral Delivery of 5‐Fluorouracil Targeted to Colon: Screening with Preliminary In Vivo Studies

Synthesis and Characterization of Biodegradable Hydrogels for Oral Delivery of 5‐Fluorouracil Targeted to Colon: Screening with Preliminary In Vivo Studies

Integration of nondegradable polystyrene and degradable gelatin in a core–sheath nanofibrous patch for pelvic reconstruction

Injectable Polyethylene Glycol Gel as Dermal Filler: 01 Year Clinical and Ultrasound Follow-Up

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Development of Hydrogels and Biomimetic Regulators as Tissue Engineering Scaffolds

Cited by 42 publications

References 119 publications

Synthesis and Characterization of Biodegradable Hydrogels for Oral Delivery of 5‐Fluorouracil Targeted to Colon: Screening with Preliminary In Vivo Studies

Synthesis and Characterization of Biodegradable Hydrogels for Oral Delivery of 5‐Fluorouracil Targeted to Colon: Screening with Preliminary In Vivo Studies

Integration of nondegradable polystyrene and degradable gelatin in a core&ndash;sheath nanofibrous patch for pelvic reconstruction

Injectable Polyethylene Glycol Gel as Dermal Filler: 01 Year Clinical and Ultrasound Follow-Up

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Integration of nondegradable polystyrene and degradable gelatin in a core–sheath nanofibrous patch for pelvic reconstruction