Schiff based injectable hydrogel for in situ pH-triggered delivery of doxorubicin for breast tumor treatment

Shi, Junbin; Wang, Guobao; Chen, Hongli; Zhong, Wen; Qiu, Xiaozhong; Xing, Malcolm

doi:10.1039/c4py00631c

Cited by 103 publications

(69 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For example, the obvious difference in pH between normal tissues (pH ∼ 7.4) and acidic tumor tissues (pH < 6.8) has motivated researchers to design pH-responsive polymeric prodrugs via acid-labile covalent linkages like benzoicimine bond, 39 Schiff's base bond, 40 and hydrazone bond 41 for tumor targeted delivery. Kataoka et al 42 have reported a pH-sensitive polymeric prodrugs by which doxorubicin (DOX) was conjugated to the poly(ethylene glycol)-b-poly(β-benzyl-L-aspartate) through acid-sensitive hydrazone linkages, which showed a highly sensitive drug release under an acidic microenvironment.…”

mentioning

confidence: 99%

An injectable drug-loaded hydrogel based on a supramolecular polymeric prodrug

et al. 2015

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 99%

An injectable drug-loaded hydrogel based on a supramolecular polymeric prodrug

et al. 2015

View full text Add to dashboard Cite

show abstract

“…In this work, a polysaccharide hydrogel was synthetized via Schiff base reaction between carboxymethyl chitosan (CMCTS) and glucan. In addition, Schiff base itself has antibacterial, sterilization, antitumor, and antiviral bioactive . Water‐insoluble VCZ was loaded through the inclusion into the β‐cyclodextrin (β‐CD) cavity on the linear poly β‐CD chain, which was in situ twined in the cross‐linked structure formed by polyaldehyde dextran (PAD) and CMCTS in the physiological solution .…”

Section: Introductionmentioning

confidence: 99%

Injectable Schiff base polysaccharide hydrogels for intraocular drug loading and release

Yang

Gao

Liu³

et al. 2019

J Biomedical Materials Res

View full text Add to dashboard Cite

A novel voriconazole (VCZ)‐loaded injectable hydrogel was in situ synthetized via a Schiff base reaction between polyaldehyde dextran (PAD) and carboxymethyl chitosan (CMCTS) for intraocular drug loading and release. Water‐insoluble VCZ, which is an effective agent in clinic treating fungal endophthalmitis, was loaded through the inclusion into the β‐cyclodextrin (β‐CD) cavity based on host‐guest interaction on the linear poly β‐CD chain, which was in situ twined in the cross‐linked hydrogel structure. The gelation time, degradation, and drug release process were investigated by studying three kinds of hydrogels with different volume ratio of PAD to CMCTS resolving in phosphate buffered saline (PBS) solution (3:7, 6:7, 9:7), respectively. The property of VCZ‐loaded injectable hydrogel should be adjusted through changing the cross‐linked density of the hydrogel, the molecular weight or concentration of the linear poly β‐CD to meet the treating requirement, and a multistage drug controlled‐release mechanism was proposed. In conclusion, the VCZ‐loaded in situ injectable hydrogel should be offered as a promising strategy for intraocular drug delivery in vitreous cavity for the treatment of fungal endophthalmitis. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1909–1916, 2019.

show abstract

“…These scaffolds play the role of the extracellular matrix (ECM) to organize cells into a 3D structure and to deliver stimuli, which regulate the tissue's growth and generation. 11 Polymers derived from natural materials such as collagen, HA, chitosan and alginate are frequently used in tissue engineering, because they have low toxicity and similar macromolecular components to the natural ECM. 10 Because of the similar architecture to the ECM of many tissues, they can help to promote cell proliferation and cell function.…”

Section: Introductionmentioning

confidence: 99%

Adipose stem cell-laden injectable thermosensitive hydrogel reconstructing depressed defects in rats: filler and scaffold

Xiao

Dong

et al. 2015

J. Mater. Chem. B

Self Cite

View full text Add to dashboard Cite

Facial depressed defects are a common cosmetic problem. Temporary fillers need to be re-injected frequently to maintain the desired outcomes. Here, the feasibility of a novel type of injectable hydrogel for persistent effect is demonstrated. We first useed agmatine to synthesize a poly(amidoamine) (PAA) to form a cell-attachable crosslinker and then the crosslinker was co-polymerized with N-isopropylacrylamide to obtain an injectable and temperature sensitive hydrogel. 1 H NMR showed the successful synthesis of the crosslinker. In vitro tests, CCK-8 assay and live/dead viability test showed that the hydrogel was non-toxic to adipose-derived stem cells (ASCs). SEM images also confirmed that ASCs could adhere to the hydrogel.Then we constructed a novel depressed defect model in rats and injected four different fillers in the depressed defects: (1) the hydrogel with ASCs, (2) the hydrogel only, (3) hyaluronic acid, and (4) PBS. After 4 weeks, gross and histological analyses showed the defects in hydrogel, hydrogel + ASCs, and HA groups improved significantly and there were no significant differences among them. Significant differences in thickness from skin to muscle in the defect was found between the hydrogel + ASCs group and the other groups after 6 months. The hydrogels degraded completely in defects in both the hydrogel group and the hydrogel + ASCs group, and were filled with adipocytes and multilocular immature adipocytes.Immunohistochemical study using s-100 and perilipin staining revealed adipocyte differentiation in the defect sites. We also used green fluorescent protein (GFP)-ASCs for tracing and found that exogenous added ASCs were involved in adipogenesis. In conclusion, such a cell attachable thermosensitive hydrogel has definite potential not only as a filler but also as a scaffold, and has a persistent effect for small depressed defects. It might ultimately become a new material in plastic and reconstructive surgery. Fig. 7 (A) Perilipin staining (adipocyte, red arrows) in all groups (scale bar = 100 mm). (B) Positive perilipin area was measured (* P o 0.05). (C) s-100-positive cells (yellow arrows) were seen in the regenerated tissues (scale bar, left = 100 mm, right = 300 mm).

show abstract

Schiff based injectable hydrogel for in situ pH-triggered delivery of doxorubicin for breast tumor treatment

Cited by 103 publications

References 56 publications

An injectable drug-loaded hydrogel based on a supramolecular polymeric prodrug

An injectable drug-loaded hydrogel based on a supramolecular polymeric prodrug

Injectable Schiff base polysaccharide hydrogels for intraocular drug loading and release

Adipose stem cell-laden injectable thermosensitive hydrogel reconstructing depressed defects in rats: filler and scaffold

Contact Info

Product

Resources

About