2005
DOI: 10.1111/j.1365-2230.2005.01749.x
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Photoprotective effect of Pothomorphe umbellata root extract against ultraviolet radiation induced chronic skin damage in the hairless mouse

Abstract: In this study we evaluated the activity of Pothomorphe umbellata root extract on hairless mice chronically exposed to UVB radiation (76.5 mJ/cm(2), 4 days per week for 22 weeks). Mouse dorsal surfaces were treated topically with 20 mg/cm(2) of a carbomer 940 gel (vehicle) with or without P. umbellata root extract to a final concentration of 0.1%, for 2 h before irradiation. Another irradiated group received no topical treatment. A fourth group received no treatment and was not irradiated. Visible skin wrinklin… Show more

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Cited by 38 publications
(26 citation statements)
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“…A representative section is shown from each treatment group (n = 10). Scale bar: control for 50 m, others for 100 m. tasia, atrophy, fine and coarse wrinkling, and a variety of benign and malignant neoplasms (Ropke et al, 2005;Cho et al, 2007). It has been reported that vitamins A, E, and C and procyanidins exert photoprotective effects on photodamaged skin due to their antioxidant activities (Mittal et al, 2003).…”
Section: Discussionmentioning
confidence: 98%
“…A representative section is shown from each treatment group (n = 10). Scale bar: control for 50 m, others for 100 m. tasia, atrophy, fine and coarse wrinkling, and a variety of benign and malignant neoplasms (Ropke et al, 2005;Cho et al, 2007). It has been reported that vitamins A, E, and C and procyanidins exert photoprotective effects on photodamaged skin due to their antioxidant activities (Mittal et al, 2003).…”
Section: Discussionmentioning
confidence: 98%
“…In vivo photoprotective effect of P. umbellatum root extract gel against UV irradiation-induced chronic skin damage (skin wrinkling) in hairless mice Ropke et al (2005) Ethanolic extract of the root Ethanolic extract of the root in gel containing 0.1% 4-nerolidylcatechol Strong in vitro inhibitory effect of P. umbellatum extract (100 g/ml extract containing 7.09 g/ml 4NC) on MMP-2 and MMP-9 measured by gelatin zymography In vivo inhibition of constitutive MMP-9 activity in mice sacrificed 2 h after UVB irradiation as measured by gelatin zymography and histological analysis Ropke et al (2006) Methanolic extract of the leaves In vitro antileishmanial activity against Leishmania amazonensis and Leishmania chagasi with amphotericin B as control drug (IC50 = 39 g/ml and IC50 = >250 g/ml, respectively) Braga et al (2007) Ethanolic extract of the stem and leaf In vitro antitrypanosomal activity against Trypanosoma brucei rhodesiense (IC50 = 2 g/ml)…”
Section: -Nerolidylcatecholmentioning
confidence: 99%
“…Perrazo et al (2005) have confirmed the anti-inflammatory and analgesic properties of P. umbellata leaf extracts using an animal model, which supports its traditional use in the treatment of inflammatory disorders. In addition, 4-nerolidylcatechol, found in leaves and roots of pariparoba, is the active constituent responsible for potent antioxidant activity on the skin and an effective reduction of UV-B-skin photo-aging (Ropke et al 2003(Ropke et al , 2005(Ropke et al , 2006.…”
Section: Introductionmentioning
confidence: 99%