Photomodulated Nanozyme Used for a Gram-Selective Antimicrobial

Abstract

Although broad-spectrum antibacterial agents have been developed for antibacterial treatment, the balance of microbial flora may break and this usually results in increasing resistance. To this end, developing simple and effective strain-selective bactericidal strategies are demanding. Herein we designed an intelligent Gram-selective antimicrobial system based on MoS2 and a photoacid molecule. This system can be modulated by light for surface charge conversion from negative to positive and simultaneously activation of the enzymatic activity of MoS2 by changing pH. In consideration of the different cell wall composition and structures of bacterial strains, Gram-selective antibacterial has been accomplished simply by controlling the light irradiation time. Taken together, we provided a simple and efficient photoregulated method to realize strain-selective antibacterial.

When Nanozymes Meet Single‐Atom Catalysis

“…To the best of our knowledge,t he complex protein scaffold is responsible for the high selectivity and efficiency of natural enzymes.However,nanozymes are intrinsically deficient in their fine structure and thus lack the finesse of enzyme-catalyzed reactions,t hereby resulting in unsatisfactory selectivity and activity.I na ddition, the atomic composition and structural complexity of nanomaterials endow ad iverse range of nanozyme catalytic mechanisms.F or example,m any transitionmetal-based nanozymes,such as Fe 3 O 4 , MnO 2 ,V 2 O 5 ,M oS 2 ,a nd so on, with intrinsic peroxidase,o xidase,c atalase,a nd superoxide dismutase activity,h ave been discovered. [4,[19][20][21][22][23] TheF enton or Fenton-like reactions are widely used to explain the catalytic mechanism of peroxidase mimics.T he generated COH can be used for the degradation of organic pollutants and in the treatment of cancer, as well as in biosensing applications. [24] Another catalytic mechanism of peroxidase mimics,w hich occurs in Prussian blue and its cyanometalate structural analogues,i st he electron transfer effects.…”

Antibiotic‐Free Antibacterial Strategies Enabled by Nanomaterials: Progress and Perspectives

“…However, Pd nanoparticles dominated by {111} facets preferentially penetrate into the bacteria to exert their antibacterial activity. A similar gram‐selective antimicrobial strategy was reported by Qu and his colleagues, where the surface charge and ROS generation of layered MoS 2 nanozymes were modulated by the time of photo illumination, achieving enhanced S. aureus killing with short irradiation and E. coli inhibition with prolonged irradiation.…”

Enzyme Mimic Nanomaterials and Their Biomedical Applications

“…In 2018, Qu and co-workers reported an antimicrobial system based on MoS 2 which could be modulated by light and have a Gram-selective behavior. [68] The selectivity of the system was simply modulated by the light irradiation time. After light irradiation, the surface charge of MoS 2 could gradually convert from negative to positive and the catalytic reaction of producing hydroxyl radicals could be activated simultaneously.…”

“…B) Selective killing of Gram-negative and -positive bacteria by using MoS 2 nanomaterials. [68] Reproduced from ref. [68] with permission; copyright: 2018, American Chemical Society.…”