Enzyme Mimic Nanomaterials and Their Biomedical Applications

Shang, Yingxu; Liu, Fengsong; Wang, Yuanning; Li, Na; Ding, Baoquan

doi:10.1002/cbic.202000123

Cited by 31 publications

(16 citation statements)

References 102 publications

(129 reference statements)

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“…It can also be said that they are a special class of transferases that use water as the receptor for the transferred group. [36][37][38] 3. Materials for Nanozyme Fabrication…”

Section: Different Enzymatic Activitiesmentioning

confidence: 99%

Recent Advances in Nanozymes: From Matters to Bioapplications

Liang

et al. 2021

Adv Funct Materials

167

115

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The manufacture of bionic materials to simulate the natural counterparts has attracted extensive attention. As one of the subcategories of biomimetic materials, the development of artificial enzyme is intensive pursuing. As a kind of artificial enzyme, nanozymes are dedicated to solve the limitations of natural enzymes. In recent years, attributed to the explosive development of nanotechnology, biotechnology, catalysis science, computational design and theory calculation, research on nanozymes has made great progress. To highlight these achievements and help researchers to understand the current investigation status of nanozyme, the state‐of‐the‐art development in nanozymes from fabrication materials to bioapplications are summarized. First different raw materials are summarized, including metal‐based, metal‐free, metal‐organic frameworks‐based, and some other novel matters, which are applied to fabricate nanozymes. The different types of enzymes‐like catalytic activities of nanozymes are briefly discussed. Subsequently, the wide applications of nanozymes such as anti‐oxidation, curing diseases, anti‐bacteria, biosensing, and bioimaging are discussed. Finally, the current challenges faced by nanozymes are outlined and the future directions for advancing nanozyme research are outlooked. The authors hope this review can inspire research in the fields of nanotechnology, chemistry, biology, materials science, and theoretical computing, and can contribute to the development of nanozymes.

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“…It can also be said that they are a special class of transferases that use water as the receptor for the transferred group. [36][37][38] 3. Materials for Nanozyme Fabrication…”

Section: Different Enzymatic Activitiesmentioning

confidence: 99%

Recent Advances in Nanozymes: From Matters to Bioapplications

Liang

et al. 2021

Adv Funct Materials

167

115

View full text Add to dashboard Cite

show abstract

“…Research in this area is intended to overcome some of the common limitations of enzymes, particularly, the limited physico-chemical resistance against solvents and changes in temperature, pH or other experimental conditions [ 290 ]. Potential applications range from various biomedical applications [ 291 ], including innovative therapy [ 292 ] biosensing [ 293 , 294 ], and disinfection [ 295 ], to environmental monitoring and remediation [ 296 ]. In particular, peroxidase mimicry by CNMs ( Figure 4 ) has been widely studied [ 297 ], especially for the development of glucose biosensors [ 298 ], although hydrolase mimicry is also attracting increasing interest [ 299 ].…”

Section: Cnms For Enzyme Mimicry Inhibition or Monitoringmentioning

confidence: 99%

Carbon Nanomaterials (CNMs) and Enzymes: From Nanozymes to CNM-Enzyme Conjugates and Biodegradation

et al. 2022

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Carbon nanomaterials (CNMs) and enzymes differ significantly in terms of their physico-chemical properties—their handling and characterization require very different specialized skills. Therefore, their combination is not trivial. Numerous studies exist at the interface between these two components—especially in the area of sensing—but also involving biofuel cells, biocatalysis, and even biomedical applications including innovative therapeutic approaches and theranostics. Finally, enzymes that are capable of biodegrading CNMs have been identified, and they may play an important role in controlling the environmental fate of these structures after their use. CNMs’ widespread use has created more and more opportunities for their entry into the environment, and thus it becomes increasingly important to understand how to biodegrade them. In this concise review, we will cover the progress made in the last five years on this exciting topic, focusing on the applications, and concluding with future perspectives on research combining carbon nanomaterials and enzymes.

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“…Later on, several other research groups attempted to mimic GPx either by structural modification of ebselen or by including some structural characteristics of enzymes in their synthetically developed molecules. Recently, several nanozymes have been developed, portraying GPx-like activity more efficient than that of the above-mentioned enzyme mimics . But the number of light-responsive mimics of this enzyme having photoregulated control over their activity is rare.…”

Section: Azobenzene-based Photoresponsive Small Molecule Enzyme Mimicsmentioning

confidence: 99%

Photoresponsive Small Molecule Enzyme Mimics

2022

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Enzyme mimics emulate the catalytic activities of their natural counterparts. Light-responsive enzyme mimics are an emerging branch of biomimetic chemistry where the catalytic activities can be controlled reversibly by light. These light-responsive systems are constructed by incorporating a suitable photoswitchable unit around the active-site mimic. As these systems are addressable by light, they do not leave back any undesired side products, and their activation–deactivation can be easily controlled. Naturally, these systems have enormous potential in the field of on-demand catalysis. The synthetic light-responsive enzyme mimics are robust and stable under harsh conditions. They do not require special handling protocols like those for real enzymes and can be tailor-made for improved solubility in a variety of solvents. How the introduction of the light-responsive systems has offered a new-edge to the field of small-molecule enzyme mimic has been elaborated in this Mini-review. Recent breakthroughs in light-responsive enzyme-like systems have been highlighted. Finally, the current obstacles and future prospects of this field have been discussed.

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Enzyme Mimic Nanomaterials and Their Biomedical Applications

Cited by 31 publications

References 102 publications

Recent Advances in Nanozymes: From Matters to Bioapplications

Recent Advances in Nanozymes: From Matters to Bioapplications

Carbon Nanomaterials (CNMs) and Enzymes: From Nanozymes to CNM-Enzyme Conjugates and Biodegradation

Photoresponsive Small Molecule Enzyme Mimics

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