“…1B, 2B ). Oxysterols with molecular weight of constitute the majority of the oxysterols observed in these SLOS models, DHCEO being one of irradiation ( 68 ). It is worth noting that although there is a good correlation between the levels of DHCEO and 7-DHC, the amount of DHCEO formed per unit of 7-DHC varies in different system.…”
Section: Antioxidant Reduces the Levels Of Dhceo In Slos Hfsmentioning
“…1B, 2B ). Oxysterols with molecular weight of constitute the majority of the oxysterols observed in these SLOS models, DHCEO being one of irradiation ( 68 ). It is worth noting that although there is a good correlation between the levels of DHCEO and 7-DHC, the amount of DHCEO formed per unit of 7-DHC varies in different system.…”
Section: Antioxidant Reduces the Levels Of Dhceo In Slos Hfsmentioning
“…Endogenous synthesis is initiated in the skin by the conversion of 7-dehydrocholesterol to previtamin D3 by ultraviolet radiation [31]. Through two sequential hydroxylation steps in the liver and then in the kidney, the active form of vitamin D, 1,25(OH) 2 D, is formed.…”
Section: Comparisons Of Various Parameters In the Presence Or Absencementioning
“…One is the fate of 7-dehydrocholesterol, the immediate precursor of cholesterol. 7-Dehydrocholesterol is observed at very low levels or is not normally detectable in tissues and fluids of humans except in skin (3)(4)(5), where it is converted to previtamin D 3 under UV irradiation (6). Thus, 7-dehydrocholesterol is important aside from its reduction to cholesterol.…”
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