Photometabolism of 7-dehydrocholesterol to previtamin D3 in skin

An oxysterol biomarker for 7-dehydrocholesterol oxidation in cell/mouse models for Smith-Lemli-Opitz syndrome

“…1B, 2B ). Oxysterols with molecular weight of constitute the majority of the oxysterols observed in these SLOS models, DHCEO being one of irradiation ( 68 ). It is worth noting that although there is a good correlation between the levels of DHCEO and 7-DHC, the amount of DHCEO formed per unit of 7-DHC varies in different system.…”

High serum vitamin D levels reduce the risk for nonalcoholic fatty liver disease in healthy men independent of metabolic syndrome

“…Endogenous synthesis is initiated in the skin by the conversion of 7-dehydrocholesterol to previtamin D3 by ultraviolet radiation [31]. Through two sequential hydroxylation steps in the liver and then in the kidney, the active form of vitamin D, 1,25(OH) 2 D, is formed.…”

Conversion of 7-Dehydrocholesterol to 7-Ketocholesterol Is Catalyzed by Human Cytochrome P450 7A1 and Occurs by Direct Oxidation without an Epoxide Intermediate

“…One is the fate of 7-dehydrocholesterol, the immediate precursor of cholesterol. 7-Dehydrocholesterol is observed at very low levels or is not normally detectable in tissues and fluids of humans except in skin (3)(4)(5), where it is converted to previtamin D 3 under UV irradiation (6). Thus, 7-dehydrocholesterol is important aside from its reduction to cholesterol.…”