High serum vitamin D levels reduce the risk for nonalcoholic fatty liver disease in healthy men independent of metabolic syndrome

Rhee, Eun-Jung; Kim, Mee Kyoung; Park, Se Eun; Park, Cheol‐Young; Baek, Ki Hyun; Lee, Won Young; Kang, Moo Il; Park, Sung Woo; Kim, Sun-Woo; Oh, Ki Won

doi:10.1507/endocrj.ej12-0387

Cited by 83 publications

(84 citation statements)

References 40 publications

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“…VD levels have been shown to be related to more severe fibrosis and reduced response to interferons in viral liver diseases (28,29). Finally, in a recent cross-sectional study of about 6500 Korean men participating in a health-screening program, patients with NAFLD had lower VD levels than those without NAFLD and such a difference persisted after correction for BMI and the MS (30).…”

Section: Discussionmentioning

confidence: 96%

Vitamin D levels and liver histological alterations in children with nonalcoholic fatty liver disease

Nobili

Giorgio

Liccardo

et al. 2014

European Journal of Endocrinology

103

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Objective: To investigate the association between plasma vitamin D (VD) levels and histological liver damage in children with nonalcoholic fatty liver disease (NAFLD). Subjects and methods: In this cross-sectional study, carried out in a tertiary care center for obesity, 73 consecutive overweight and obese children with persistently elevated serum aminotransferase levels and diffusely hyperechogenic liver on ultrasonography were selected for liver biopsy. Nonalcoholic steatohepatitis (NASH) and fibrosis were histologically diagnosed using NAFLD Clinical Research Network (CRN) criteria. The plasma levels of 25-OH-VD were measured by HPLC. Bone mineral density (BMD) of lumbar spine was evaluated by dual-energy X-ray absorptiometry. Multiple linear regression analysis was used to evaluate the association between 25-OH-VD levels and the predictors of interest after correction for age, gender, waist circumference, BMI, and other potential confounders. Results: The children (64% males) were aged 8-18 years, and their median BMI was 2.45 SDS. Both parathyroid hormone levels and BMD were within the normal range. All cases of fibrosis were detected in children with NASH. On multivariable linear regression with correction for age, gender, and BMI, 25-OH-VD levels were found to be 9 (95% CI 12-6) ng/ml lower in children with NASH than in those without NASH (P!0.001) and 9 (12-6) ng/ml lower in children with stage 1 fibrosis than in those with stage 0 fibrosis and 9 (13-6) ng/ml lower in children with stage 2 than in those with stage 0 fibrosis (P!0.001 for both). Conclusion: VD levels are inversely associated with NASH and fibrosis in children with NAFLD.

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Section: Discussionmentioning

confidence: 96%

Vitamin D levels and liver histological alterations in children with nonalcoholic fatty liver disease

Nobili

Giorgio

Liccardo

et al. 2014

European Journal of Endocrinology

103

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“…In a study of 6567 men who underwent abdominal US and measurement of vitamin D levels, there was a significant association between NAFLD and low vitamin D (108). The lowest tertiles of vitamin D were associated with NAFLD even after adjustment for the presence of other features of the metabolic syndrome.…”

Section: Vitamin Dmentioning

confidence: 99%

Mechanisms in endocrinology: Non-alcoholic fatty liver disease in common endocrine disorders

Hazlehurst

Tomlinson

2013

European Journal of Endocrinology

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Non-alcoholic fatty liver disease (NAFLD) is a spectrum of disease spanning from simple benign steatosis to steatohepatitis with fibrosis and scarring that can eventually lead to cirrhosis. Its prevalence is rising rapidly and is developing into the leading indication for liver transplantation worldwide. Abnormalities in endocrine axes have been associated with NALFD, including hypogonadism, hypothyroidism, GH deficiency and hypercortisolaemia. In some instances, correction of the endocrine defects has been shown to have a beneficial impact. While in patients with type 2 diabetes the association with NAFLD is well established and recognised, there is a more limited appreciation of the condition among common endocrine diseases presenting with hormonal excess or deficiency. In this review, we examine the published data that have suggested a mechanistic link between endocrine abnormalities and NAFLD and summarise the clinical data endorsing these observations.

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“…Hepatic expression of vitamin D receptors, CYP2R1 and CYP 27A1, negatively correlates with the severity of steatosis, inflammation, and NAFLD scores in patients with this disease [80] . A recent study found a significant association between NAFLD and low serum vitamin D levels [81] ; this relationship remained significant even after adjustments were made for the presence of other metabolic syndrome features. Evidence from liver biopsies have shown that serum vitamin D levels are significantly related with the stage of hepatic fibrosis [82] .…”

Section: Vitamin Dmentioning

confidence: 91%

Recent advances in dietary supplementation, in treating non-alcoholic fatty liver disease

Eslamparast¹,

Eghtesad²,

Poustchi³

et al. 2014

WJH

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High serum vitamin D levels reduce the risk for nonalcoholic fatty liver disease in healthy men independent of metabolic syndrome

Cited by 83 publications

References 40 publications

Vitamin D levels and liver histological alterations in children with nonalcoholic fatty liver disease

Vitamin D levels and liver histological alterations in children with nonalcoholic fatty liver disease

Mechanisms in endocrinology: Non-alcoholic fatty liver disease in common endocrine disorders

Recent advances in dietary supplementation, in treating non-alcoholic fatty liver disease

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