Photoluminescence and magnetic analysis of a family of lanthanide(<scp>iii</scp>) complexes based on diclofenac

Echenique‐Errandonea, Estitxu; Oyarzabal, Itziar; Cepeda, Javier; Sebastián, Eider San; Rodríguez-Diéguez, Antonio; Seco, José M.

doi:10.1039/c7nj00794a

Cited by 19 publications

(4 citation statements)

References 88 publications

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“…Very differently, a single-exponential function can describe the decay curve of Tb- S 3 (Figure S9b), giving the τ value of 1.01 ms, this value is obviously longer than that of Eu- R 1 , but comparable with that of [Tb( R -pba) 3 (phen)] 2 (τ = 1.08 ms) . The Tb(III) complex represents a much longer lifetime than the Eu(III) analogue, which can be attributed to the former having a more predominant charge transfer . The solid-state fluorescence quantum yields of Eu- R 1 and Tb- S 3 were measured using Edinburgh FLS980 to be 17.41% (λ ex = 398 nm) and 4.62% (λ ex = 360 nm), respectively.…”

Section: Resultsmentioning

confidence: 94%

Enantiopure Chiral Two-dimensional Sinusoidal Lanthanide(III) Coordination Polymers Based on R-/S-2-Methylglutarate: Luminescence, Magnetic Entropy Change, and Magnetic Relaxation

Liu

Zhang

Hao

et al. 2019

Crystal Growth & Design

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As a base for neutralizing homochiral dicarboxylic acids [R-/S-2-methylglutaric acid, abbreviated as (R/S)-2-MG] rather than an N-donor ligand, 1,3-di(4-pyridyl)propane participates in the self-assembly of isostructural, homochiral lanthanide(III) coordination polymers derived from (R/S)-2-MG at room temperature, which show 2D sinusoidal ruffling (4, 4) network structures with the formulas {). Among them, the europium(III) and terbium(III) compounds show solid fluorescent properties characteristic of lanthanide(III) ions, while the dysprosium(III) compound may exhibit magnetic relaxation. Furthermore, the magnetic entropy change or magnetocaloric effect of the gadolinium(III) complex is studied.

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Section: Resultsmentioning

confidence: 94%

Enantiopure Chiral Two-dimensional Sinusoidal Lanthanide(III) Coordination Polymers Based on R-/S-2-Methylglutarate: Luminescence, Magnetic Entropy Change, and Magnetic Relaxation

Liu

Zhang

Hao

et al. 2019

Crystal Growth & Design

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“…Sodium diclofenac (Nadicl) ( Figure 1 A) is an analgesic, antipyretic, and anti-inflammatory agent [ 36 ] proposed for the treatment of rheumatoid arthritis and osteoarthritis [ 37 , 38 ]. However, recent studies have shown that the use of sodium diclofenac may increase the cardiovascular problems when compared to paracetamol and other traditional NSAIDs [ 39 ].…”

Section: Introductionmentioning

confidence: 99%

Iron(III) Complexes with Non-Steroidal Anti-Inflammatory Drugs: Structure, Antioxidant and Anticholinergic Activity, and Interaction with Biomolecules

Dimiza

Barmpa

Chronakis

et al. 2023

IJMS

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One the main research goals of bioinorganic chemists is the synthesis of novel coordination compounds possessing biological potency. Within this context, three novel iron(III) complexes with the non-steroidal anti-inflammatory drugs diflunisal and diclofenac in the presence or absence of the nitrogen donors 1,10-phenanthroline or pyridine were isolated and characterized by diverse techniques. The complexes were evaluated for their ability to scavenge in vitro free radicals such as hydroxyl, 1,1-diphenyl-2-picrylhydrazyl and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radicals, revealing their selective potency towards hydroxyl radicals. The in vitro inhibitory activity of the complexes towards the enzymes acetylcholinesterase and butyrylcholinesterase was evaluated, and their potential to achieve neuroprotection appeared promising. The interaction of the complexes with calf-thymus DNA was examined in vitro, revealing their ability to intercalate in-between DNA nucleobases. The affinity of the complexes for serum albumins was evaluated in vitro and revealed their tight and reversible binding.

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“…21−23 The potassium and sodium salts of dcf (commonly known as diclofenac) are well-known nonsteroid anti-inflammatory drugs. 24 The coordination chemistry of dcf and phen with transition metals is known; 25,26 however, to date, no reports are published on alkali metal complexes with phen / dcf mixed ligand systems. As a continuation of our search for new potential bioactive compounds, 27 we have sought to combine the established enzyme inhibition properties of phen with the anti-inflammatory properties of dcf through the development of structurally well-defined alkali metal complexes of phen / dcf as potentially bioactive compounds.…”

Section: Introductionmentioning

confidence: 99%

“…phen is a well-known N-donor ligand with predictable coordination chemistry, offering a N , N ′-chelate pocket for metal ions and is often employed with a range of O-donor coligands to produce a range of complexes with different structural topologies. − phen is also a well-known enzyme inhibitor. − The potassium and sodium salts of dcf (commonly known as diclofenac) are well-known nonsteroid anti-inflammatory drugs . The coordination chemistry of dcf and phen with transition metals is known; , however, to date, no reports are published on alkali metal complexes with phen / dcf mixed ligand systems. As a continuation of our search for new potential bioactive compounds, we have sought to combine the established enzyme inhibition properties of phen with the anti-inflammatory properties of dcf through the development of structurally well-defined alkali metal complexes of phen / dcf as potentially bioactive compounds.…”

Section: Introductionmentioning

confidence: 99%

Sodium, Potassium, and Lithium Complexes of Phenanthroline and Diclofenac: First Report on Anticancer Studies

Shah

Khan³

et al. 2019

ACS Omega

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Diclofenac or 2-[(2′,6′-dichlorophenyl)amino]phenyl}acetic acid (dcf) is a nonsteroidal anti-inflammatory drug, and 1,10-phenanthroline (phen) is a well-known enzyme inhibitor. In this study, three new alkali metal complexes (1–3) containing both phen and dcf were prepared, and their structures were characterized by a variety of analytical techniques including infrared and UV–vis spectroscopy, 1H NMR and 13C NMR elemental analysis, mass spectrometry, and single-crystal X-ray diffraction analysis. In these complexes, phen binds via a N,N′-chelate pocket, while the monoanionic dcf—ligand remains either uncoordinated (in the case of 1 and 3) or coordinated in a bidentate fashion (in the case of 2). All three complexes crystallize in the triclinic space group P-1. [Na2(phen)2 (H2O)4][dcf]2 (1) is a dinuclear sodium complex, where two crystallographically identical Na+ cations adopt a distorted five-coordinate spherical square-pyramidal geometry, with a [N2O3] donor set. [K2(phen)2(dcf)2(H2O)4] (2) is also a dinuclear complex where the crystallographically unique K+ cation adopts a distorted seven-coordinate geometry comprising a [N2O5] donor set. [Li(phen)(H2O)2][dcf] (3) is a mononuclear lithium complex where the Li+ cation adopts a four-coordinate distorted tetrahedral geometry comprising a [N2O2] donor set. The complexes were evaluated for their anticancer activity against lung and oral cancer cell lines as well as for their antibacterial potential. The prepared complexes displayed very good antibacterial and anticancer activities with an excellent bioavailability.

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Photoluminescence and magnetic analysis of a family of lanthanide(iii) complexes based on diclofenac

Abstract: A family of ten isostructural complexes based on the diclofenac ligand exhibiting interesting magnetic and luminescence properties has been prepared.

Cited by 19 publications

References 88 publications

Enantiopure Chiral Two-dimensional Sinusoidal Lanthanide(III) Coordination Polymers Based on R-/S-2-Methylglutarate: Luminescence, Magnetic Entropy Change, and Magnetic Relaxation

Enantiopure Chiral Two-dimensional Sinusoidal Lanthanide(III) Coordination Polymers Based on R-/S-2-Methylglutarate: Luminescence, Magnetic Entropy Change, and Magnetic Relaxation

Iron(III) Complexes with Non-Steroidal Anti-Inflammatory Drugs: Structure, Antioxidant and Anticholinergic Activity, and Interaction with Biomolecules

Sodium, Potassium, and Lithium Complexes of Phenanthroline and Diclofenac: First Report on Anticancer Studies

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