Photoelectrochemical immunosensor based on CdSe@BiVO4 Co-sensitized TiO2 for carcinoembryonic antigen

Xie, Yongze; Zhang, Min; Bin, Qianyun; Xie, Shilei; Guo, Lu’an; Cheng, Faliang; Lv, Weizhong

doi:10.1016/j.bios.2019.111949

Cited by 49 publications

(8 citation statements)

References 22 publications

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“…Label-Free EC Immunosensors for Carcinoembryonic Antigen (CEA) Detection CEA is a glycoprotein from the immunoglobulin family [31]. It is normally produced in the gastrointestinal tissue during prenatal development but it stops being produced before birth [32]. However, low levels are still found in healthy human serum [32] with an estimated level of 2.5 ng/mL [33].…”

Section: Label-free Ec Immunosensors For Oc Biomarkers Detectionmentioning

confidence: 99%

“…It is normally produced in the gastrointestinal tissue during prenatal development but it stops being produced before birth [32]. However, low levels are still found in healthy human serum [32] with an estimated level of 2.5 ng/mL [33]. CEA is an important oncomarker for ovarian and breast cancers [16,[33][34][35] and many other cancer types such as gastric, lung, pancreatic, colorectal cancers [36] and cervical carcinoma [37].…”

Section: Label-free Ec Immunosensors For Oc Biomarkers Detectionmentioning

confidence: 99%

“…The developed simple immunosensor has a detection linear concentration range of 0.0005 to 10.0 ng/mL and LOD of 0.468 pg/mL with superior stability, selectivity and accuracy. In addition, Xie et al [32] developed a sandwich-type PEC immunosensor for quantifying CEA. Gold-decorated TiO 2 nanorods were used as signal promoter to coat an FTO electrode (Au@TiO 2 /FTO) followed by immobilization of CEA Ab 1 through EDC/NHS coupling with subsequent blocking of non-specific binding sites with BSA.…”

Section: Pec Immunosensors For Oc Biomarkers Detection 221 Pec Immuno...mentioning

confidence: 99%

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Electrochemical and Photoelectrochemical Immunosensors for the Detection of Ovarian Cancer Biomarkers

Ekwujuru

Olatunde

Klink

et al. 2023

Sensors

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Photoelectrochemical (PEC) sensing is an emerging technological innovation for monitoring small substances/molecules in biological or non–biological systems. In particular, there has been a surge of interest in developing PEC devices for determining molecules of clinical significance. This is especially the case for molecules that are markers for serious and deadly medical conditions. The increased interest in PEC sensors to monitor such biomarkers can be attributed to the many apparent advantages of the PEC system, including an enhanced measurable signal, high potential for miniaturization, rapid testing, and low cost, amongst others. The growing number of published research reports on the subject calls for a comprehensive review of the various findings. This article is a review of studies on electrochemical (EC) and PEC sensors for ovarian cancer biomarkers in the last seven years (2016–2022). EC sensors were included because PEC is an improved EC; and a comparison of both systems has, expectedly, been carried out in many studies. Specific attention was given to the different markers of ovarian cancer and the EC/PEC sensing platforms developed for their detection/quantification. Relevant articles were sourced from the following databases: Scopus, PubMed Central, Web of Science, Science Direct, Academic Search Complete, EBSCO, CORE, Directory of open Access Journals (DOAJ), Public Library of Science (PLOS), BioMed Central (BMC), Semantic Scholar, Research Gate, SciELO, Wiley Online Library, Elsevier and SpringerLink.

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Section: Label-free Ec Immunosensors For Oc Biomarkers Detectionmentioning

confidence: 99%

Section: Label-free Ec Immunosensors For Oc Biomarkers Detectionmentioning

confidence: 99%

Section: Pec Immunosensors For Oc Biomarkers Detection 221 Pec Immuno...mentioning

confidence: 99%

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Electrochemical and Photoelectrochemical Immunosensors for the Detection of Ovarian Cancer Biomarkers

Ekwujuru

Olatunde

Klink

et al. 2023

Sensors

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“…Until now, numerous analytical methods including enzyme-linked immunosorbent assay [10], electrochemiluminescence [11], surface plasmon resonance imaging [12], radioimmunoassay [13], fluorescence [14], and atomic absorption spectrometry [15] techniques have been suggested for the monitoring of AFP level. Although most of these methods have advantages such as broad detection range and low determination limit, they are not effective due to the high cost, long time of analysis, and even their complicated processes [16][17][18]. Therefore, there is still a need for a cost-effective, swift, high accuracy, and easily applicable alternative method for the monitoring of AFP level.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical α-fetoprotein immunosensor based on Fe3O4NPs@covalent organic framework decorated gold nanoparticles and magnetic nanoparticles including SiO2@TiO2

et al. 2022

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The early diagnosis of major diseases such as cancer is typically a major issue for humanity. Human α-fetoprotein (AFP) as a sialylated glycoprotein is of approximately 68 kD molecular weight and is considered to be a key biomarker, and an increase in its level indicates the presence of liver, testicular, or gastric cancer. In this study, an electrochemical AFP immunosensor based on Fe 3 O 4 NPs@covalent organic framework decorated gold nanoparticles (Fe 3 O 4 NPs@COF/AuNPs) for the electrode platform and double-coated magnetic nanoparticles (MNPs) based on SiO 2 @TiO 2 (MNPs@SiO 2 @TiO 2 ) nanocomposites for the signal amplification was fabricated. The immobilization of anti-AFP capture antibody was successfully performed on Fe 3 O 4 NPs@COF/AuNPs modified electrode surface by amino-gold affinity, while the conjugation of anti-AFP secondary antibody on MNPs@SiO 2 @TiO 2 was achieved by the electrostatic/ionic interactions. Transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) analysis, cyclic voltammetry (CV), square wave voltammetry (SWV), and electrochemical impedance spectroscopy (EIS) techniques were used to characterize the nanostructures in terms of physical and electrochemical features. The limit of detection (LOD) was 3.30 fg mL −1 . The findings revealed that the proposed electrochemical AFP immunosensor can be effectively used to diagnose cancer.

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“…In recent years, photoelectrochemical (PEC) sensors have become a research hot spot because of their low cost, wide linear range, simple operation, and high detection speed. , In a PEC sensor, the excitation signal and received signal can be fully separated, which significantly decreases the effect of background noise and increases the sensitivity of the sensor. , To date, PEC sensors have been used extensively in various fields, including drug detection, − biological antibodies or antigens, and pollutants . Photoelectric materials are core to PEC sensors.…”

Section: Introductionmentioning

confidence: 99%

A Sensitive Photoelectrochemical Sensor for Levodopa Detection Using Benzothiadiazole-Based Conjugated Microporous Polymer-Coated Graphene Heterostructures

Xiang

Liu

et al. 2022

ACS Appl. Mater. Interfaces

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Since the 1960s, levodopa (LDA) has been the standard drug for treating of Parkinson's disease. In this study, a novel benzothiadiazole-based conjugated microporous polymercoated graphene heterostructure (CMP-rGO) was synthesized and used to construct a sensitive photoelectrochemical (PEC) sensor capable of detecting LDA. Under optimal experimental conditions, the intensity of the photocurrent produced by the sensor was linear from 0.005 to 40 μM, and the limit of detection of the sensor was 0.0027 μM. The sensor showed good repeatability, stability, and selectivity for LDA detection. Finally, the constructed sensor was used to detect LDA in levodopa tablets, human serum samples, and urine samples and satisfactory results were obtained. Therefore, the PEC sensor provides a novel platform for the detection of LDA in real samples and broadens the applications of conjugated microporous polymers in PEC sensing.

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Photoelectrochemical immunosensor based on CdSe@BiVO4 Co-sensitized TiO2 for carcinoembryonic antigen

Cited by 49 publications

References 22 publications

Electrochemical and Photoelectrochemical Immunosensors for the Detection of Ovarian Cancer Biomarkers

Electrochemical and Photoelectrochemical Immunosensors for the Detection of Ovarian Cancer Biomarkers

Electrochemical α-fetoprotein immunosensor based on Fe3O4NPs@covalent organic framework decorated gold nanoparticles and magnetic nanoparticles including SiO2@TiO2

A Sensitive Photoelectrochemical Sensor for Levodopa Detection Using Benzothiadiazole-Based Conjugated Microporous Polymer-Coated Graphene Heterostructures

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